Ramesh Bhosale
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View article: The Association of Anemia With Gut Microbiota in Maternal-Infant Populations From India
The Association of Anemia With Gut Microbiota in Maternal-Infant Populations From India Open
View article: A randomised controlled non-inferiority trial to compare the efficacy of ‘HPV screen, triage and treat’ with ‘HPV screen and treat’ approach for cervical cancer prevention among women living with HIV
A randomised controlled non-inferiority trial to compare the efficacy of ‘HPV screen, triage and treat’ with ‘HPV screen and treat’ approach for cervical cancer prevention among women living with HIV Open
We report results of a randomized controlled trial to compare 'HPV screen and treat' (Arm 1) and 'HPV screen, triage and treat' (Arm 2) in women living with HIV (WLHIV), using visual inspection with acetic acid (VIA) as the triaging test. …
View article: HIV-related Differences in Placental Immunology: Data From the PRACHITi Cohort in Pune, India
HIV-related Differences in Placental Immunology: Data From the PRACHITi Cohort in Pune, India Open
Background Maternal HIV infection can affect placental immunology and expression of the neonatal crystallizable fragment receptor (FcRn), which allows transplacental antibody transfer. This study delineated differences in placental FcRn an…
View article: Discordance of 3rd and 4th generation QuantiFERON-TB Gold assays by pregnancy stages in India
Discordance of 3rd and 4th generation QuantiFERON-TB Gold assays by pregnancy stages in India Open
View article: Impact of Human Immunodeficiency Virus Drug Resistance Mutations Detected in Women Prior to Antiretroviral Therapy With Efavirenz + Tenofovir Disoproxil Fumarate + Lamivudine (or Emtricitabine)
Impact of Human Immunodeficiency Virus Drug Resistance Mutations Detected in Women Prior to Antiretroviral Therapy With Efavirenz + Tenofovir Disoproxil Fumarate + Lamivudine (or Emtricitabine) Open
Background Two large studies suggest that resistance mutations to only nonnucleoside reverse transcriptase inhibitors (NNRTI) did not increase the risk of virologic failure during antiretroviral therapy (ART) with efavirenz/tenofovir disop…
View article: Discordance of 3rd and 4th Generation Quantiferon-Tb Gold Assays by Pregnancy Stages in India
Discordance of 3rd and 4th Generation Quantiferon-Tb Gold Assays by Pregnancy Stages in India Open
View article: Association of Pregnancy and HIV Status With Molecular-Bacterial Vaginosis in Indian Women
Association of Pregnancy and HIV Status With Molecular-Bacterial Vaginosis in Indian Women Open
Background: Bacterial vaginosis (BV) is a highly prevalent disorder of the cervicovaginal microbiota. Molecular-BV may put women at increased risk for adverse reproductive and obstetric outcomes. We investigated the association of HIV and …
View article: The Association of Gestational Diabetes with HIV Infection and Tuberculosis in Indian Women
The Association of Gestational Diabetes with HIV Infection and Tuberculosis in Indian Women Open
Infection of HIV is associated with an increased diabetes risk, which also increases tuberculosis risk. It is unknown if similar associations exist with gestational diabetes (GDM). We screened pregnant women living with and without HIV for…
View article: Maternal and infant renal safety following tenofovir disoproxil fumarate exposure during pregnancy in a randomized control trial
Maternal and infant renal safety following tenofovir disoproxil fumarate exposure during pregnancy in a randomized control trial Open
Background Tenofovir disoproxil fumarate (TDF) in combination with other antiretroviral (ARV) drugs has been in clinical use for HIV treatment since its approval in 2001. Although the effectiveness of TDF in preventing perinatal HIV infect…
View article: Clinical Profile of SARS-CoV-2-Infected Neonates
Clinical Profile of SARS-CoV-2-Infected Neonates Open
Background There are conflicting data on the mother-to-child transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and few studies have described the clinical course of neonates infected with SARS-CoV-2. Objectives T…
View article: Transcriptional Analysis for Tuberculosis in Pregnant Women From the PRegnancy Associated Changes In Tuberculosis Immunology (PRACHITi) Study
Transcriptional Analysis for Tuberculosis in Pregnant Women From the PRegnancy Associated Changes In Tuberculosis Immunology (PRACHITi) Study Open
A new tuberculosis (TB) diagnostic cartridge assay, which detects a 3-gene TB signature in whole blood, was not diagnostic in women with maternal TB disease in India (area under the curve [AUC] = 0.72). In a cohort of pregnant women, we id…
View article: Association of Maternal Inflammation During Pregnancy With Birth Outcomes and Infant Growth Among Women With or Without HIV in India
Association of Maternal Inflammation During Pregnancy With Birth Outcomes and Infant Growth Among Women With or Without HIV in India Open
This study suggests that increased levels of certain systemic inflammatory markers, including interleukin 1β and interleukin 17A, during pregnancy were associated with adverse birth outcomes and infant growth deficits. Future studies shoul…
View article: Efficacy, safety, and lot-to-lot immunogenicity of an inactivated SARS-CoV-2 vaccine (BBV152): interim results of a randomised, double-blind, controlled, phase 3 trial
Efficacy, safety, and lot-to-lot immunogenicity of an inactivated SARS-CoV-2 vaccine (BBV152): interim results of a randomised, double-blind, controlled, phase 3 trial Open
View article: Stages of pregnancy and HIV affect diagnosis of tuberculosis infection and Mycobacterium tuberculosis (MTB)-induced immune response: Findings from PRACHITi, a cohort study in Pune, India
Stages of pregnancy and HIV affect diagnosis of tuberculosis infection and Mycobacterium tuberculosis (MTB)-induced immune response: Findings from PRACHITi, a cohort study in Pune, India Open
Pregnancy affects TBI test results and reduces IFN-γ response to M. tuberculosis stimulation. Despite adequate CD4 counts, women with HIV express less IFN-γ than women without HIV, which may explain the high TB incidence in postpartum wome…
View article: Impact of HIV status on systemic inflammation during pregnancy
Impact of HIV status on systemic inflammation during pregnancy Open
Objective: There are limited studies on the association of HIV infection with systemic inflammation during pregnancy. Design: A cohort study ( N = 220) of pregnant women with HIV ( N = 70) (all on antiretroviral therapy) and without HIV ( …
View article: TB‐related knowledge and stigma among pregnant women in low‐resource settings
TB‐related knowledge and stigma among pregnant women in low‐resource settings Open
View article: Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection
Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection Open
Background Recent studies in adults have characterized differences in systemic inflammation between adults with and without latent tuberculosis infection (LTBI+ vs . LTBI−). Potential differences in systemic inflammation by LTBI status has…
View article: Impact of HIV status on systemic inflammation during pregnancy Running Head: Inflammation in pregnant women with HIV
Impact of HIV status on systemic inflammation during pregnancy Running Head: Inflammation in pregnant women with HIV Open
1Department of Epidemiology, Columbia University Mailman School of Public Health, New
\nYork, USA
\n2Department of Medicine, Weill Cornell Medical College, New York, USA
\n3Department of Biostatistics, Columbia University Mailman School of…
View article: Validation of New Interactive Nutrition Assistant - Diet in India Study of Health (NINA-DISH) FFQ with multiple 24-h dietary recalls among pregnant women in Pune, India
Validation of New Interactive Nutrition Assistant - Diet in India Study of Health (NINA-DISH) FFQ with multiple 24-h dietary recalls among pregnant women in Pune, India Open
Adequate dietary intake is critical to prevent adverse pregnancy outcomes. India has a high burden of maternal and child morbidity and mortality, but there is a lack of adequate tools to assess dietary intake. We validate an FFQ, New Inter…
View article: Association of Vegetable and Animal Flesh Intake with Inflammation in Pregnant Women from India
Association of Vegetable and Animal Flesh Intake with Inflammation in Pregnant Women from India Open
In pregnant women, studies are lacking on the relationship of vegetable and animal flesh (poultry, red meat and seafood) intake with inflammation, especially in low- and middle-income countries. We conducted a cohort study of pregnant wome…
View article: Pharmacokinetics and Drug‐Drug Interactions of Isoniazid and Efavirenz in Pregnant Women Living With HIV in High TB Incidence Settings: Importance of Genotyping
Pharmacokinetics and Drug‐Drug Interactions of Isoniazid and Efavirenz in Pregnant Women Living With HIV in High TB Incidence Settings: Importance of Genotyping Open
The World Health Organization guidelines recommend that individuals living with HIV receive ≥ 6 months of isoniazid preventive therapy, including pregnant women. Yet, plasma isoniazid exposure during pregnancy, in the antiretroviral therap…
View article: Early-onset symptomatic neonatal COVID-19 infection with high probability of vertical transmission
Early-onset symptomatic neonatal COVID-19 infection with high probability of vertical transmission Open
View article: Systemic Inflammation i 1 n Pregnant Women with 2 Latent Tuberculosis Infection
Systemic Inflammation i 1 n Pregnant Women with 2 Latent Tuberculosis Infection Open
United States National Institutes of
\n374 Health, NIH, Bethesda, MD, USA (R00HD089753 to RS and R01HD081929 to AG). JSM received
\n375 support from NIAID (K23AI129854). Additional support for this work was the NIH-funded Johns
\n376 Hopki…
View article: Isoniazid Preventive Therapy in HIV-Infected Pregnant and Postpartum Women
Isoniazid Preventive Therapy in HIV-Infected Pregnant and Postpartum Women Open
The risks associated with initiation of isoniazid preventive therapy during pregnancy appeared to be greater than those associated with initiation of therapy during the postpartum period. (Funded by the National Institutes of Health; IMPAA…
View article: Vitamin D status and risk of incident tuberculosis disease: A nested case-control study, systematic review, and individual-participant data meta-analysis
Vitamin D status and risk of incident tuberculosis disease: A nested case-control study, systematic review, and individual-participant data meta-analysis Open
Our findings suggest vitamin D predicts TB disease risk in a dose-dependent manner and that the risk of TB disease is highest among HIV-positive individuals with severe vitamin D deficiency. Randomized control trials are needed to evaluate…
View article: Vitamin D status and risk of incident tuberculosis disease: a systematic review and individual participant data meta-analysis
Vitamin D status and risk of incident tuberculosis disease: a systematic review and individual participant data meta-analysis Open
Background Few studies have evaluated the association between pre-existing vitamin D deficiency (VDD) and incident TB. We assessed the impact of baseline vitamin D on TB risk. Methods We assessed the association between baseline vitamin D …
View article: Intestinal Barrier Dysfunction and Microbial Translocation in Human Immunodeficiency Virus–Infected Pregnant Women Are Associated With Preterm Birth
Intestinal Barrier Dysfunction and Microbial Translocation in Human Immunodeficiency Virus–Infected Pregnant Women Are Associated With Preterm Birth Open
NCT00061321.
View article: Maternal Syphilis: An Independent Risk Factor for Mother to Infant Human Immunodeficiency Virus Transmission
Maternal Syphilis: An Independent Risk Factor for Mother to Infant Human Immunodeficiency Virus Transmission Open
Syphilis is associated with increased human immunodeficiency virus acquisition and sexual transmission; we examined impact on human immunodeficiency virus mother-to-child transmission among mother-infant pairs enrolled in the India Six-Wee…
View article: Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention
Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention Open
Antenatal ART resulted in significantly lower rates of early HIV transmission than zidovudine alone but a higher risk of adverse maternal and neonatal outcomes. (Funded by the National Institutes of Health; PROMISE ClinicalTrials.gov numbe…
View article: Rates and determinants of incidence and clearance of cervical HPV genotypes among HIV-seropositive women in Pune, India
Rates and determinants of incidence and clearance of cervical HPV genotypes among HIV-seropositive women in Pune, India Open