Explanipedia

Cardiac Damage Staging, Moderate Aortic Stenosis, and the Impact of Aortic Valve Replacement Open

Evan Harmon, Travis Howard, Grant W. Reed, Elizabeth Ghandakly, James Yun , et al. · 2025

Cardiac Damage Staging in Moderate or Greater Aortic Regurgitation: A New Framework for Risk Stratification Open

Francisco B. Alexandrino, Ian Persits, Joseph Hajj, Ziad Zalaquett, Velusamy Karthik , et al. · 2025

Background: Cardiac damage staging is an established prognostic tool in aortic stenosis, and an initial application to aortic regurgitation (AR) showed prognostic relevance, mainly in advanced stages. No dedicated framework currently exist…

Pegfilgrastim (Neulasta)-induced acute aortitis: a case report Open

Pranay Marlecha, Samir Kapadia, Akiva Rosenzveig, Robert A. Wolff, Aravinda Nanjundappa · 2025

Background Granulocyte colony-stimulating factor (G-CSF) and especially pegfilgrastim for its long-lasting effects are commonly used to lower the chances of neutropenia during chemotherapy. However, extremely rarely, it may result in large…

Finerenone in Patients Undergoing TAVR for Nonrheumatic Aortic Stenosis: Insights from a Real-World Cohort Open

Faysal Massad, Osamah Badwan, Akiva Rosenzveig, Fawzi Zghyer, Zaid Shahrori , et al. · 2025

Characteristics of Hemorrhagic Myocardial Infarction After ST-Segment Elevation Myocardial Infarction in the United States Open

Ankur Kalra, Keyur Vora, Vivek Bhat, Ashish Kumar, Khurram Nasir , et al. · 2025

Surgical Aortic Valve Replacement Following TAVR: Long-Term Comparative Outcomes Versus Non-SAVR Cardiac Surgery Open

Osamah Badwan, Issam Motairek, Fawzi Zghyer, Rishi Puri, Grant Reed , et al. · 2025

SAVR after TAVR was associated with similar long-term outcomes compared with OHS. These findings suggest that risks may be more related to patient complexity than to the valve explant itself.

Mitral Annular Function in Mitral Annular Calcification and Severe Mitral Regurgitation Open

Joseph Kassab, Joseph Hajj, Serge C. Harb, Rhonda Miyasaka, Grant Reed , et al. · 2025

CCT can quantify mitral annular function and its contribution to LVSV. Moderate-to-severe MAC significantly impairs annular function, reducing its share of LVSV. These findings may inform patient selection for transcatheter mitral therapie…

Tricuspid valve replacement outcomes by baseline tricuspid regurgitation severity: the TRISCEND II trial Open

Philipp Lurz, Rebecca T. Hahn, Susheel Kodali, Raj Makkar, Rahul Sharma , et al. · 2025

Background and Aims The TRISCEND II trial demonstrated superior clinical benefits for patients with ≥severe tricuspid regurgitation (TR) treated with the EVOQUE transcatheter tricuspid valve replacement (TTVR) system plus medical therapy v…

Cerebral Embolic Protection Device Use, Stroke, and Disabling Stroke in TAVR Before and After PROTECTED-TAVR Open

Akiva Rosenzveig, Ankit Agrawal, Osamah Badwan, Grant Reed, Rishi Puri , et al. · 2025

Establishing Cardiovascular Centers on Aging Open

Abdulla A. Damluji, Ardeshir Z. Hashmi, Nishok Karthikeyan, Oliver Glen Ancheta, Samir Kapadia , et al. · 2025

Mid-Term Outcomes of Balloon-Expandable Aortic Valve-in-Valve Replacement in the United States Open

Amar Krishnaswamy, Amr E. Abbas, Vasilis Babaliaros, Adam B. Greenbaum, Pradeep Yadav , et al. · 2025

This large, real-world analysis confirms the safety and durability of AViV compared with TAVR at all surgical risk levels at mid-term follow-up. Consideration may be given to broadening the indication for AViV.

Clinical Outcomes Following Tricuspid Transcatheter Valve Replacement – A Meta-analysis Open

Taha Hatab, Osamah Badwan, Radwan Alkhatib, Akiva Rosenzveig, Mangesh Kritya , et al. · 2025

The iron woman: a case report of contemporary cardiac support Open

Jeremy Brooksbank, Nikolaos Spilias, Carmela D. Tan, Randall C. Starling, Samir Kapadia · 2025

Background Modern cardiovascular practice utilizes various devices and procedures to treat functional and structural heart disease. Case summary We report an interesting case of a female patient with heart failure with reduced ejection fra…

Outcomes of Transcatheter or Surgical Treatment of Severe Aortic Stenosis in Patients With Coronary Artery Disease Open

Joseph Kassab, Joseph Hajj, Rishi Puri, James Yun, Grant Reed , et al. · 2025

Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure Open

Brian R. Lindman, Andrew Perry, Michelle L Lance, Kaushik Amancherla, Namju Kim , et al. · 2025

Pressure overload initiates a series of alterations in the human heart that predate macroscopic organ-level remodeling and downstream heart failure. We study aortic stenosis through integrated proteomic, tissue transcriptomic, and genetic …

A Heart Failure Society of America-Developed Educational Module Improves Clinician Comfort With Initiation and Optimization of Guideline-Directed Medical Therapy Open

Brittany Chapman, Nancy M. Albert, Alex Zajichek, Eva Steinel, David A. Baran , et al. · 2025

Democratizing cardiac imaging with an automated magnetic resonance exam Open

Danielle Kara, Ashmita Deb, Hoa Quang Le, Daniel Wee, Makiya Nakashima , et al. · 2025

Neo-Sinus Washout Time Following Transcatheter Aortic Valve Replacement and Hemodynamic Outcomes Open

Shivabalan Kathavarayan Ramu, Toshiaki Isogai, Saksham Beotra, Vishwum Kapadia, Nimish Thakore , et al. · 2025

71850 | Transcatheter Edge-to-Edge Repair With MitraClip for Papillary Muscle Rupture in Acute Coronary Syndrome: A Systematic Review of 1-Year Outcomes Open

Radwan Alkhatib, Taha Hatab, Osamah Badwan, Akiva Rosenzveig, Faysal Massad , et al. · 2025

3-Year Outcomes of Mitral Valve-in-Valve Therapy Using Balloon-Expandable Transcatheter Valves in the United States Open

Mackram F. Eleid, Amar Krishnaswamy, Samir Kapadia, Pradeep Kumar Yadav, Vivek Rajagopal , et al. · 2025

Three-year survival after MViV is highest in low STS scores and elective procedures, whereas survival was significantly lower in high STS scores and nonelective procedures. These findings emphasize the importance of early identification an…

71851 | Outcomes of Transcatheter Tricuspid Valve Replacement Across Devices: A Comprehensive Pooled Analysis Open

Taha Hatab, Radwan Alkhatib, Osamah Badwan, Akiva Rosenzveig, Faysal Massad , et al. · 2025

72034 | Transcatheter Tricuspid Valve Replacement in Patients With Cardiac Implantable Electronic Device Endocardial Leads: The TRIPLACE Registry Open

Bryan Traynor, Andrea Scotti, Rishi Puri, Matteo Sturla, Firas Zahr , et al. · 2025

Transcatheter Versus Surgical Aortic Valve Replacement in Patients with Polyvascular Disease Open

Abdelrhman Abomoawad, Ramy Sedhom, Harsh Golwala, Mohamed Abdelazeem, Mamas Mamas , et al. · 2025

Nationwide data demonstrated that patients with PVD who undergo TAVR were associated with lower in-hospital mortality and major cardiovascular complications compared with those who undergo SAVR. Patients with PVD have similar mortality to …

Outcomes and Predictors of Flow Improvement After Transcatheter Aortic Valve Replacement in Patients With Low-Flow Low-Gradient Aortic Stenosis Open

Besir Besir, Maryam Muhammad Ali Majeed-Saidan, Shivabalan Kathavarayan Ramu, Tamari Lomaia, Judah Rajendran , et al. · 2025

One-third of patients with LFLG AS show an improvement in flow post-TAVR. Paradoxical LFLG AS, male sex, lower baseline SVI, and improvement in LVEF correlated with flow improvement, whereas baseline LVEF did not. There was no difference i…

Association of a Comprehensive ST‐Segment–Elevation Myocardial Infarction Protocol With Key Process Metrics Among Patients Transferred for Primary Percutaneous Coronary Intervention Open

Radoslav Zinoviev, Anirudh Kumar, Chetan Huded, Michael J. Johnson, Kathleen Kravitz , et al. · 2025

Background Most US patients with ST‐segment–elevation myocardial infarction (STEMI) transferred for percutaneous coronary intervention (PCI) do not achieve the goal door‐to‐balloon time (D2BT) of ≤120 minutes. We evaluated the impact of a …

Management of Coronary Artery Disease in Patients Undergoing Transcatheter Aortic Valve Replacement Open

Judah Rajendran, Shivabalan Kathavarayan Ramu, Akhilesh Khuttan, Besir Besir, Tamari Lomaia , et al. · 2025

E-72 | Percutaneous Coronary Intervention in Patients Undergoing Transcatheter Aortic Valve Implantation - A Cleveland Clinic Experience Open

Judah Rajendran, Shivabalan Kathavarayan Ramu, Akhilesh Khuttan, Danial Nasif, Besir Besir , et al. · 2025

Utilization and Outcomes of Antiplatelet Therapy Following Transcatheter Aortic Valve Replacement (TAVR) Open

Agam Bansal, Grant W. Reed, Rishi Puri, James Yun, Amar Krishnaswamy , et al. · 2025

Two-Year Outcomes of Transcatheter Edge-to-Edge Repair for Severe Tricuspid Regurgitation: The TRILUMINATE Pivotal Randomized Controlled Trial Open

Saibal Kar, Raj Makkar, Brian Whisenant, Nadira Hamid, Hursh Naik , et al. · 2025

BACKGROUND: One-year outcomes of TRILUMINATE Pivotal (Trial to Evaluate Cardiovascular Outcomes in Patients Treated With the Tricuspid Valve Repair System Pivotal) found that transcatheter edge-to-edge repair (TEER) for the treatment of se…

Acute Frame Recoil Following Transcatheter Mitral Valve-in-Valve Replacement: Incidence and Impact on Hemodynamics Open

Judah Rajendran, Shivabalan Kathavarayan Ramu, Besir Besir, Maryam Muhammad Ali Majeed-Saidan, Aditya Mantha , et al. · 2025

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