Rami Darwich
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View article: Endothelial Corneal Dystrophy
Endothelial Corneal Dystrophy Open
Fuchs endothelial corneal dystrophy (FECD) was first described by Ernst Fuchs in 1910. It is a bilateral corneal endothelial dystrophy characterized by progressive loss of corneal endothelial cells and formation of excrescences at the leve…
View article: Risk of glaucoma with bisphosphonate use in patients with osteoporosis
Risk of glaucoma with bisphosphonate use in patients with osteoporosis Open
Purpose Bisphosphonates (BPs) are first line agents commonly used in the management of osteoporosis. There have been two case reports that have suggested a possible link between BPs and acute angle closure (AAC). In the absence of any larg…
View article: PreserFlo Microshunt for the management of intraocular pressure elevation in iridocorneal endothelial syndrome
PreserFlo Microshunt for the management of intraocular pressure elevation in iridocorneal endothelial syndrome Open
The PreserFlo Microshunt may be a promising option for patients with ICE syndrome who fail medical therapy. Implantation of this device was well tolerated in the presented case.
View article: Medications for Attention Deficit Hyperactivity Disorder Associated with Increased Risk of Developing Glaucoma
Medications for Attention Deficit Hyperactivity Disorder Associated with Increased Risk of Developing Glaucoma Open
Background Attention deficit hyperactivity disorder (ADHD) therapies including atomoxetine, methylphenidate, and amphetamines are some of the most prescribed medications in North America. Due to their sympathomimetic action, these drugs ar…
View article: Annular pigment ring on the posterior lens capsule: a novel examination finding in blunt ocular trauma
Annular pigment ring on the posterior lens capsule: a novel examination finding in blunt ocular trauma Open
View article: Interleukin-1β expression is positively correlated with cyclooxygenase-2 expression in basal cell carcinoma of the eyelid
Interleukin-1β expression is positively correlated with cyclooxygenase-2 expression in basal cell carcinoma of the eyelid Open
View article: Is Elafin Part of a Protective System in Basal Cell Carcinomas of the Eyelid
Is Elafin Part of a Protective System in Basal Cell Carcinomas of the Eyelid Open
View article: Targeted Gene Therapy of the Corneal Endothelium using Functionalized Nanoparticle Assisted Femtosecond Laser Technology
Targeted Gene Therapy of the Corneal Endothelium using Functionalized Nanoparticle Assisted Femtosecond Laser Technology Open
View article: AB087. Corneal phenotype of a Slc4a11 knockout murine model for congenital hereditary endothelial dystrophy
AB087. Corneal phenotype of a Slc4a11 knockout murine model for congenital hereditary endothelial dystrophy Open
Background: Congenital hereditary endothelial dystrophy (CHED) is characterized by blindness at birth or in early infancy resulting from bilateral corneal opacification, and is linked to mutation in the Slc4a11 gene. A Slc4a11 knockout (KO…
View article: KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5
KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5 Open
TBX5, a member of the T-box family of transcription factors, is a dosage sensitive regulator of heart development. Mutations in TBX5 are responsible for Holt-Oram Syndrome, an autosomal dominant disease with variable and partially penetran…
View article: Functional Analysis of KLF13 in the Heart
Functional Analysis of KLF13 in the Heart Open
Congenital heart defects (CHD) are the largest class of birth defects in humans and are a major cause of infant mortality and morbidity. Deciphering the molecular and genetic etiologies central for heart development and the pathogenesis of…
View article: Nuclear Receptor-Like Structure and Interaction of Congenital Heart Disease-Associated Factors GATA4 and NKX2-5
Nuclear Receptor-Like Structure and Interaction of Congenital Heart Disease-Associated Factors GATA4 and NKX2-5 Open
The results provide novel insight into the structural basis for protein-protein interactions between two important classes of transcription factors. The model proposed will help to elucidate the molecular basis for disease causing mutation…