Ramith Ramu
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View article: Enhancement of Amaranthus dubius seed β-Amylase activity from the iron oxide Nanoparticle synthesized from Azadirachta indica
Enhancement of Amaranthus dubius seed β-Amylase activity from the iron oxide Nanoparticle synthesized from Azadirachta indica Open
This research aimed to synthesize nanoparticle (NPs) through environment friendly “green synthesis” method using neem leaf extract as a reducing agent and determine the impact of different Iron Oxide Nanoparticle (FeO-NPs) concentrations o…
View article: Exploring the therapeutic potential of phytochemicals apigenin and ellagic acid in managing polycystic ovarian syndrome and its comorbidities: a comprehensive review
Exploring the therapeutic potential of phytochemicals apigenin and ellagic acid in managing polycystic ovarian syndrome and its comorbidities: a comprehensive review Open
Polycystic Ovarian Syndrome (PCOS) is a complex endocrine and metabolic disorder affecting women of reproductive age, characterized by hyperandrogenism, insulin resistance, chronic inflammation, and ovulatory dysfunction. Conventional ther…
View article: Sulfonamides: a versatile scaffold for diverse biological activity
Sulfonamides: a versatile scaffold for diverse biological activity Open
Sulfonamides remain a cornerstone of medicinal chemistry, serving as a versatile scaffold for the design of clinically significant therapeutics. While previous reviews have summarized their broad biological activities, this article uniquel…
View article: Identification and 3D modeling of bioactive peptides from Lactobacillus brevis RAMULAB49 protein hydrolysate with in silico ERK1 phosphorylation inhibition activity targeting diabetic nephropathy
Identification and 3D modeling of bioactive peptides from Lactobacillus brevis RAMULAB49 protein hydrolysate with in silico ERK1 phosphorylation inhibition activity targeting diabetic nephropathy Open
Diabetic nephropathy (DN) poses a significant health challenge, necessitating novel therapeutic approaches. In this study, we isolated proteins from cell-free supernatant (CFS) from the culture of the lactic acid bacteria Lactobacillus bre…
View article: Synthesis and <i>In vitro</i> Biological Evaluation of Quinolone-Based Hydrazones as Potential Antidiabetic Agents Targeting Key Metabolic Enzymes
Synthesis and <i>In vitro</i> Biological Evaluation of Quinolone-Based Hydrazones as Potential Antidiabetic Agents Targeting Key Metabolic Enzymes Open
A series of novel structures featuring quinolone-based hydrazones (5a-5q) were synthesized, characterized, and screened for their potential inhibition of key enzymes involved in carbohydrate metabolism, namely human pancreati…
View article: Plant-derived gamma-aminobutyric acid (GABA): Role in stress responses, growth, metabolism, and therapeutic potential for neuropsychiatric disorders
Plant-derived gamma-aminobutyric acid (GABA): Role in stress responses, growth, metabolism, and therapeutic potential for neuropsychiatric disorders Open
View article: Protocol for isolation, fractionation, and system biology-based profiling of gastrointestinal digested dairy colostrum and milk proteome
Protocol for isolation, fractionation, and system biology-based profiling of gastrointestinal digested dairy colostrum and milk proteome Open
Colostrum and milk from dairy sources consist of whey, casein, and fat, which have notable pharmacological properties due to their proteins and peptides. Here, we present a protocol for isolating, simulating in vitro gastrointestinal diges…
View article: A protocol for assessing the adhesion potential of lactic acid bacteria on various cell types
A protocol for assessing the adhesion potential of lactic acid bacteria on various cell types Open
Lactic acid bacteria (LAB) are a large group produced during carbohydrate fermentation, resulting in lactic acid. Here, we present a protocol for probiotic adhesion and interaction into buccal epithelial cells, chicken epithelial cells, an…
View article: Fermented sugarcane juice-derived probiotic Levilactobacillus brevis RAMULAB54 enhances lipid metabolism and glucose homeostasis through PPAR-γ activation
Fermented sugarcane juice-derived probiotic Levilactobacillus brevis RAMULAB54 enhances lipid metabolism and glucose homeostasis through PPAR-γ activation Open
The gut microbiota plays a significant role in metabolic disorders such as diabetes and obesity, with the peroxisome proliferator-activated receptor gamma (PPAR-γ) being a key regulator in adipogenesis and glucose metabolism. This study is…
View article: EXPLORING JACKFRUIT FLOUR POLYPHENOLS AS PROMISING SGLT-2 INHIBITORS FOR HYPERGLYCEMIA MANAGEMENT
EXPLORING JACKFRUIT FLOUR POLYPHENOLS AS PROMISING SGLT-2 INHIBITORS FOR HYPERGLYCEMIA MANAGEMENT Open
Objective: This study explored the potential of dietary polyphenols from whole green jackfruit flour as natural Sodium-Glucose Co-Transporter-2 (SGLT-2) inhibitors for managing hyperglycemia in diabetes mellitus. Methods: Advanced bio-comp…
View article: Antioxidant, enzyme kinetics, α-amylase, α-glucosidase inhibition and molecular docking studies of (S,N,O⁻) type Schiff’s Base and its Pd(II) complex
Antioxidant, enzyme kinetics, α-amylase, α-glucosidase inhibition and molecular docking studies of (S,N,O⁻) type Schiff’s Base and its Pd(II) complex Open
View article: In silico exploration of 6-sulfonyl-8-nitrobenzothiazinone derivatives as mycobacterium tuberculosis GyrB inhibitors: Molecular docking, md simulation, DFT, and pharmacokinetic studies
In silico exploration of 6-sulfonyl-8-nitrobenzothiazinone derivatives as mycobacterium tuberculosis GyrB inhibitors: Molecular docking, md simulation, DFT, and pharmacokinetic studies Open
View article: Synthesis, Characterization, Antibacterial and In-Silico Studies of New Series of Fluorinated Pyrazole Clubbed Benzimidazole Hydrazone Derivatives
Synthesis, Characterization, Antibacterial and In-Silico Studies of New Series of Fluorinated Pyrazole Clubbed Benzimidazole Hydrazone Derivatives Open
View article: Computational techniques for analyzing and interpreting some quinoxaline-containing molecules as possible anti-schistosomal agents using docking, pharmacokinetics, drug-likeness, QSAR, and molecular dynamics evaluation
Computational techniques for analyzing and interpreting some quinoxaline-containing molecules as possible anti-schistosomal agents using docking, pharmacokinetics, drug-likeness, QSAR, and molecular dynamics evaluation Open
View article: Cell-free supernatant of Levilactobacillus brevis (RAMULAB51) from coconut inflorescence sap (Neera) enhances glucose uptake and PPAR-γ in 3T3-L1 adipocytes and inhibits α-glucosidase and α-amylase
Cell-free supernatant of Levilactobacillus brevis (RAMULAB51) from coconut inflorescence sap (Neera) enhances glucose uptake and PPAR-γ in 3T3-L1 adipocytes and inhibits α-glucosidase and α-amylase Open
Introduction Lactic acid bacteria are prized for their probiotic benefits and gut health improvements. This study assessed five LAB isolates from Neera, with RAMULAB51 ( Levilactobacillus brevis , GenBank ON171686.1) standing out for its h…
View article: Novel Quinoline- and Naphthalene-Incorporated Hydrazineylidene–Propenamide Analogues as Antidiabetic Agents: Design, Synthesis, and Computational Studies
Novel Quinoline- and Naphthalene-Incorporated Hydrazineylidene–Propenamide Analogues as Antidiabetic Agents: Design, Synthesis, and Computational Studies Open
Background: Type 2 diabetes has become a significant global health challenge. Numerous drugs have been developed to treat the condition, either as standalone therapies or in combination when glycemic control cannot be achieved with a singl…
View article: Thiazolyl-Thiazolidinone Conjugated Pyrazoles as Potential Anticancer and Antibacterial Agents and Molecular Docking Studies
Thiazolyl-Thiazolidinone Conjugated Pyrazoles as Potential Anticancer and Antibacterial Agents and Molecular Docking Studies Open
In current study, five new compounds containing thiazolyl-thiazolidinone conjugated substituted pyrazoles were prepared and screened for anticancer and antimicrobial activities. Synthesized compounds were characterized by spectroscopic tec…
View article: Novel Benzimidazole-Endowed Chalcones as α-Glucosidase and α-Amylase Inhibitors: An Insight into Structural and Computational Studies
Novel Benzimidazole-Endowed Chalcones as α-Glucosidase and α-Amylase Inhibitors: An Insight into Structural and Computational Studies Open
In search of novel antidiabetic agents, we synthesized a new series of chalcones with benzimidazole scaffolds by an efficient ‘one-pot’ nitro reductive cyclization method and evaluated their α-glucosidase and α-amylase inhibition studies. …
View article: Sauerkraut‐derived <scp>LAB</scp> strains as potential probiotic candidates for modulating carbohydrate digestion attributing bacterial organic acid profiling to antidiabetic activity
Sauerkraut‐derived <span>LAB</span> strains as potential probiotic candidates for modulating carbohydrate digestion attributing bacterial organic acid profiling to antidiabetic activity Open
Sauerkraut‐derived lactic acid bacterial (LAB) strains have gained attention due to their potential health benefits. This study focuses on evaluating seven Sauerkraut‐derived RAMULAB strains isolated from sauerkraut, aiming to identify pro…
View article: Natural product-inspired [3 + 2] cycloaddition-based spirooxindoles as dual anticancer agents: synthesis, characterization, and biological evaluation by <i>in vitro</i> and <i>in silico</i> methods
Natural product-inspired [3 + 2] cycloaddition-based spirooxindoles as dual anticancer agents: synthesis, characterization, and biological evaluation by <i>in vitro</i> and <i>in silico</i> methods Open
A newly synthesized spirooxindole pyrrolothiazole derivative exhibited promising anticancer activity against both breast and colorectal cancer cells.
View article: Sestrin 2 as a new biomarker in obesity and diabetes mellitus: A new key player in the metabolic regulation
Sestrin 2 as a new biomarker in obesity and diabetes mellitus: A new key player in the metabolic regulation Open
View article: From sugar binders to diabetes fighters: the lectin saga of antihyperglycemic activity through systematic review and meta-analysis
From sugar binders to diabetes fighters: the lectin saga of antihyperglycemic activity through systematic review and meta-analysis Open
Introduction Lectins are carbohydrate-binding proteins that are extremely selective for sugar groups in the other molecules. As a result, they perform a variety of roles in biological processes involving cell, carbohydrate, and protein rec…
View article: Effect of repeated heating on Chemical Properties of selected edible plant oil and its Health Hazards
Effect of repeated heating on Chemical Properties of selected edible plant oil and its Health Hazards Open
Increase in the cost price of edible oil, has forced to reuse the cooking oil especially in frying. Repeated cooking of oil brings about lot of structural changes ideally not suitable for consumption. The present study aims at comparing th…
View article: Characterization of <i>Lactobacillus</i> spp. as Probiotic and Antidiabetic Potential Isolated from Boza, Traditional Fermented Beverage in Turkey
Characterization of <i>Lactobacillus</i> spp. as Probiotic and Antidiabetic Potential Isolated from Boza, Traditional Fermented Beverage in Turkey Open
Boza, a cereal‐based beverage popular in southeast Europe, is fortified with probiotics and is believed to positively impact the composition of the gut microflora. This investigation focused on fermented cereal‐based beverage boza to ident…
View article: QSAR application of natural therapeutics inhibitors against Alzheimer's disease through in-silico virtual-screening, docking-simulation, molecular dynamics, and pharmacokinetic prediction analysis
QSAR application of natural therapeutics inhibitors against Alzheimer's disease through in-silico virtual-screening, docking-simulation, molecular dynamics, and pharmacokinetic prediction analysis Open
Alzheimer's disease (AD) is a brain disorder that is known to be one of the deadliest diseases affecting humanity, especially adults from the age of sixty (60) years and above. It mostly affects thinking ability, behaviour and social skill…
View article: In-silico screening and ADMET evaluation of therapeutic MAO-B inhibitors against Parkinson disease
In-silico screening and ADMET evaluation of therapeutic MAO-B inhibitors against Parkinson disease Open
MAOs are flavoenzymes that aid in the oxidative deamination of neurotransmitters such as dopamine, serotonin, and epinephrine. MAO inhibitors are antidepressants that act by inhibiting neurotransmitter breakdown in the brain and controllin…
View article: Investigating the antidiabetic efficacy of dairy-derived Lacticaseibacillus paracasei probiotic strains: modulating α-amylase and α-glucosidase enzyme functions
Investigating the antidiabetic efficacy of dairy-derived Lacticaseibacillus paracasei probiotic strains: modulating α-amylase and α-glucosidase enzyme functions Open
The current study aims to evaluate and characterize the probiotic andantidiabetic properties of lactic acid bacteria (LAB) obtained from milk and other dairy-based products. The strains were tested physiologically, biochemically, and molec…
View article: Effect of selective serotonin reuptake inhibitors on blood glucose in euglycemic and streptozotocin-induced diabetic albino Wistar rats
Effect of selective serotonin reuptake inhibitors on blood glucose in euglycemic and streptozotocin-induced diabetic albino Wistar rats Open
Background: Diabetes mellitus is one of the serious health concerns around the globe, characterized by hyperglycemia. It is also linked with several other disorders including neuropathy. One of the most typical diabetes-related comorbiditi…
View article: Protocol to identify multiple protein targets and therapeutic compounds using an in silico polypharmacological approach
Protocol to identify multiple protein targets and therapeutic compounds using an in silico polypharmacological approach Open
View article: Screening for potential novel probiotic Levilactobacillus brevis RAMULAB52 with antihyperglycemic property from fermented Carica papaya L.
Screening for potential novel probiotic Levilactobacillus brevis RAMULAB52 with antihyperglycemic property from fermented Carica papaya L. Open
Probiotics are live microorganisms with various health benefits when consumed in appropriate amounts. Fermented foods are a rich source of these beneficial organisms. This study aimed to investigate the probiotic potential of lactic acid b…