Ramkiran Gouripeddi
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View article: Schizophrenia, Bipolar, or Major Depressive Disorder and Postacute Sequelae of COVID-19
Schizophrenia, Bipolar, or Major Depressive Disorder and Postacute Sequelae of COVID-19 Open
Importance Given the increased vulnerability to COVID-19 among those with a serious mental illness (SMI), it remains unclear whether these individuals face a higher risk of developing postacute sequelae of SARS-CoV-2 (PASC). Understanding …
View article: Air pollution mixtures and stillbirth: k-means cluster analysis
Air pollution mixtures and stillbirth: k-means cluster analysis Open
Background: Preventing stillbirths starts with identifying modifiable risk factors, such as air pollution (AP). Most research has focused on individual components of AP (e.g. PM2.5) to assess the linear relationship between air pollutant c…
View article: Structural Homology and Electrostatic Potential Comparisons of Epitope Pair Candidates for Molecular Mimicry Triggering of Type 1 Diabetes Mellitus
Structural Homology and Electrostatic Potential Comparisons of Epitope Pair Candidates for Molecular Mimicry Triggering of Type 1 Diabetes Mellitus Open
Background Molecular mimicry, where foreign and self-peptides contain similar epitopes, can induce autoimmune responses. Identifying potential molecular mimics and studying their properties is key to understanding the onset of autoimmune d…
View article: Wearable-derived Sleep Measurements are Associated with Long-COVID in the RECOVER Adult Cohort
Wearable-derived Sleep Measurements are Associated with Long-COVID in the RECOVER Adult Cohort Open
Wearables yield a wide array of sleep-related measures that are relevant to Long COVID. We leveraged wearables-derived sleep measures (WDSM) to identify differences between individuals with Long COVID (LC) versus individuals with possible …
View article: Scaling Sensor Metadata Extraction for Exposure Health Using LLMs
Scaling Sensor Metadata Extraction for Exposure Health Using LLMs Open
Background The rapid evolution and diversity of sensor technologies, coupled with inconsistencies in how sensor metadata is reported across formats and sources, present significant challenges for generating exposomes and exposure health re…
View article: Documentation of social determinants of health for patients with type 2 diabetes in Epic Cosmos
Documentation of social determinants of health for patients with type 2 diabetes in Epic Cosmos Open
Objectives Type 2 diabetes (T2D) is a growing public health burden with persistent racial and ethnic disparities. . This study assessed the completeness of social determinants of health (SdoH) data for patients with T2D in Epic Cosmos, a n…
View article: A natural language processing pipeline for identifying pediatric long COVID symptoms and functional impacts in freeform clinical notes: a RECOVER study
A natural language processing pipeline for identifying pediatric long COVID symptoms and functional impacts in freeform clinical notes: a RECOVER study Open
Objective To develop a natural language processing (NLP) pipeline for unstructured electronic health record (EHR) data to identify symptoms and functional impacts associated with Long COVID in children. Materials and Methods We analyzed 48…
View article: Social vulnerability, lower broadband internet access, and rurality associated with lower telemedicine use in U.S. Counties
Social vulnerability, lower broadband internet access, and rurality associated with lower telemedicine use in U.S. Counties Open
Objective Our objective was to determine how social vulnerabilities, broadband access, and rurality relate to telemedicine use across the United States through large-scale analysis of real-world telemedicine data. Materials and Methods We …
View article: Unlocking the Power of Data Harmonization in Environmental Health Sciences: A Comprehensive Exploration of Significance, Use Cases, and Recommendations for Standardization Efforts
Unlocking the Power of Data Harmonization in Environmental Health Sciences: A Comprehensive Exploration of Significance, Use Cases, and Recommendations for Standardization Efforts Open
Our process revealed the potential limitations of many existing harmonization approaches, with notable failures to identify common variables across independent datasets and lack of agreement between human and computer-based approaches. Thi…
View article: Conformal Learning for Quantifying Uncertainty in Psychiatric Condition Predictions
Conformal Learning for Quantifying Uncertainty in Psychiatric Condition Predictions Open
Purpose The combination of physiological data from ubiquitous fitness trackers like Fitbit® and machine learning presents a promising avenue for improving diagnostic consistency in the psychiatric space. However, machine learning models th…
View article: 20 Decoding auto-immunity: Uncovering pre-onset infectious disease patterns of idiopathic inflammatory myopathies
20 Decoding auto-immunity: Uncovering pre-onset infectious disease patterns of idiopathic inflammatory myopathies Open
Objectives/Goals: Idiopathic inflammatory myopathies (IIMs) are autoimmune diseases influenced by genetic and environmental factors. This study aims to explore infection patterns preceding IIM onset by applying temporal data mining and mac…
View article: 357 On the completeness of medical records of patients with oral health records at three CTSA CORES Institutions: Iowa, Kentucky, and Utah
357 On the completeness of medical records of patients with oral health records at three CTSA CORES Institutions: Iowa, Kentucky, and Utah Open
Objectives/Goals: Oral health is an important and understudied part of overall health. Poor oral health is linked to many systemic conditions, but little has been done to explore these issues in large electronic health records data sources…
View article: 363 The art and science of data navigation for translational research
363 The art and science of data navigation for translational research Open
Objectives/Goals: Translational researchers spend significant amounts of time finding available datasets and other research data resources for their purposes. Objectives of this program are develop and evaluate a multipronged approach to s…
View article: 347 Modeling long-term environmental effects on discrete events using shapelets: An application for stillbirth
347 Modeling long-term environmental effects on discrete events using shapelets: An application for stillbirth Open
Objectives/Goals: To develop an informatics framework that will allow study of environmental effects on stillbirth at large scale (i.e., US-level) and leverage recent advances in machine learning and artificial intelligence to produce repr…
View article: Molecular mimicry impact of the COVID-19 pandemic: Sequence homology between SARS-CoV-2 and autoimmune diseases epitopes
Molecular mimicry impact of the COVID-19 pandemic: Sequence homology between SARS-CoV-2 and autoimmune diseases epitopes Open
View article: Constructing Probabilistic Human Mobility Patterns for Estimating Total Exposures and Pathogen Transmission Using Aggregate Mobile Phone Data
Constructing Probabilistic Human Mobility Patterns for Estimating Total Exposures and Pathogen Transmission Using Aggregate Mobile Phone Data Open
While phone location data is widely collected by providers and shared under special agreements with data aggregators, it is not available for research or routine surveillance purposes. Moreover, raw phone data may expose personal travel pa…
View article: Racial and Ethnic Disparities in Prescribing of GLP-1 Receptor Agonists in the United States: A Retrospective Cohort Analysis
Racial and Ethnic Disparities in Prescribing of GLP-1 Receptor Agonists in the United States: A Retrospective Cohort Analysis Open
Background Type 2 diabetes (T2D) represents a major public health burden in the United States, with racial disparities in medication use potentially exacerbating inequities in health outcomes. This study examined racial/ethnic differences …
View article: Study protocol for the development of a real-time interface showing the availability of breast and cervical cancer services in Ghana
Study protocol for the development of a real-time interface showing the availability of breast and cervical cancer services in Ghana Open
Background The 5-year survival rates for breast and cervical cancers in Ghana are low in comparison to rates in developed countries. This striking disparity is attributed to numerous factors, including limited access and navigability to ap…
View article: Characterization and Racial Stratification of Social Determinants of Health for Individuals with Type 2 Diabetes as Recorded in Electronic Health Records: Implications for Artificial Intelligence Development
Characterization and Racial Stratification of Social Determinants of Health for Individuals with Type 2 Diabetes as Recorded in Electronic Health Records: Implications for Artificial Intelligence Development Open
Background Accurate documentation of social determinants of health (SDoH) in electronic health records (EHRs) is critical for developing equitable AI models for diabetes management. This study investigates SDoH data in a cross-institutiona…
View article: Travel Distance Between Participants in US Telemedicine Sessions With Estimates of Emissions Savings: Observational Study
Travel Distance Between Participants in US Telemedicine Sessions With Estimates of Emissions Savings: Observational Study Open
Background Digital health and telemedicine are potentially important strategies to decrease health care’s environmental impact and contribution to climate change by reducing transportation-related air pollution and greenhouse gas emissions…
View article: Social Vulnerability and Rurality Associated with Lower Telemedicine Use in U.S. Counties
Social Vulnerability and Rurality Associated with Lower Telemedicine Use in U.S. Counties Open
View article: Augmenting the Hospital Score with social risk factors to improve prediction for 30-day readmission following acute myocardial infarction
Augmenting the Hospital Score with social risk factors to improve prediction for 30-day readmission following acute myocardial infarction Open
Background: Hospital Score is a well-known and validated tool for predicting readmission risk among diverse patient populations. Integrating social risk factors using natural language processing with the Hospital Score may improve its abil…
View article: Travel Distance Between Participants in US Telemedicine Sessions With Estimates of Emissions Savings: Observational Study (Preprint)
Travel Distance Between Participants in US Telemedicine Sessions With Estimates of Emissions Savings: Observational Study (Preprint) Open
BACKGROUND Digital health and telemedicine are potentially important strategies to decrease health care’s environmental impact and contribution to climate change by reducing transportation-related air pollution and greenhouse gas emission…
View article: Evolving availability and standardization of patient attributes for matching
Evolving availability and standardization of patient attributes for matching Open
Variation in availability, format, and standardization of patient attributes across health care organizations impacts patient-matching performance. We report on the changing nature of patient-matching features available from 2010–2020 acro…
View article: Prioritization of infectious epitopes for translational investigation in type 1 diabetes etiology
Prioritization of infectious epitopes for translational investigation in type 1 diabetes etiology Open
View article: Detecting hypoglycemia-induced electrocardiogram changes in a rodent model of type 1 diabetes using shape-based clustering
Detecting hypoglycemia-induced electrocardiogram changes in a rodent model of type 1 diabetes using shape-based clustering Open
Sudden death related to hypoglycemia is thought to be due to cardiac arrhythmias. A clearer understanding of the cardiac changes associated with hypoglycemia is needed to reduce mortality. The objective of this work was to identify distinc…
View article: Sequential data mining of infection patterns as predictors for onset of type 1 diabetes in genetically at-risk individuals
Sequential data mining of infection patterns as predictors for onset of type 1 diabetes in genetically at-risk individuals Open
View article: 500 The Aging Exposome: Characterizing Bidirectional Effects of Exposures and Aging
500 The Aging Exposome: Characterizing Bidirectional Effects of Exposures and Aging Open
OBJECTIVES/GOALS: The objective of this study is to synthetically generate and use records of exposure, and so that we can understand the effects of exposure on aging and vice-versa. METHODS/STUDY POPULATION: Quantifying bidirectional effe…
View article: 297 Identifying Opportunities and Challenges for Translational Informatics Approaches to Real-World Data: A Diabetes Case Study
297 Identifying Opportunities and Challenges for Translational Informatics Approaches to Real-World Data: A Diabetes Case Study Open
OBJECTIVES/GOALS: Diabetes is a group of chronic metabolic diseases and significant gaps remain in our understanding of disease etiology, treatment regimens, and diabetes-related complications. The objective of study is to demonstrate how …
View article: Healthcare Provider Reports on Social Determinants of Health in Opioid Treatment
Healthcare Provider Reports on Social Determinants of Health in Opioid Treatment Open
Opioid overdose and death from overdose continue to present a pressing problem in the United States. It is well-established that a range of social and economic factors, often referred to as social determinants of health (SDOH), are associa…