Ramkumar Iyer
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View article: Molecular drivers of resistance to sulbactam-durlobactam in contemporary clinical isolates of<i>Acinetobacter baumannii</i>
Molecular drivers of resistance to sulbactam-durlobactam in contemporary clinical isolates of<i>Acinetobacter baumannii</i> Open
Acinetobacter baumannii - calcoaceticus complex (ABC) causes severe infections that are difficult to treat due to pre-existing antibiotic resistance. Sulbactam-durlobactam (SUL-DUR) is a targeted β-lactam/β-lactamase inhibitor combination …
View article: A Fluorescent Microplate Assay Quantifies Bacterial Efflux and Demonstrates Two Distinct Compound Binding Sites in AcrB
A Fluorescent Microplate Assay Quantifies Bacterial Efflux and Demonstrates Two Distinct Compound Binding Sites in AcrB Open
A direct assay of efflux by Escherichia coli AcrAB-TolC and related multidrug pumps would have great value in discovery of new Gram-negative antibiotics. The current understanding of how efflux is affected by the chemical structure and phy…