Ramón Landín-Romero
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View article: Subregional Amygdala Functional Connectivity at 3T: Comparison of High‐Resolution 2D and 3D fMRI Acquisitions
Subregional Amygdala Functional Connectivity at 3T: Comparison of High‐Resolution 2D and 3D fMRI Acquisitions Open
Background and Purpose Amygdala dysfunction is implicated in major depressive disorder. Despite wide acknowledgement of its heterogeneity, the amygdala is predominantly considered as a single entity and functional connectivity investigatio…
View article: Differential diagnosis of dementias using in vivo MRI and data-driven disease progression modelling: a case study in Alzheimer’s disease and dementia with Lewy bodies
Differential diagnosis of dementias using in vivo MRI and data-driven disease progression modelling: a case study in Alzheimer’s disease and dementia with Lewy bodies Open
Alzheimer’s disease (AD) and Dementia with Lewy bodies (DLB) are neurodegenerative diseases often sharing clinical symptoms, causing frequent misdiagnoses. Using data from multiple cohorts we improve and apply the SuStaIn algorithm on regi…
View article: Comparison of neuron-derived extracellular vesicles miRNA profile between patients with behavioural variant frontotemporal dementia and primary psychiatric disorders
Comparison of neuron-derived extracellular vesicles miRNA profile between patients with behavioural variant frontotemporal dementia and primary psychiatric disorders Open
The behavioural variant of frontotemporal dementia (bvFTD) often overlaps clinically with primary psychiatric disorders (PPD), leading to frequent misdiagnosis and delayed intervention. The "Diagnostic and Prognostic Precision Algorithm fo…
View article: Discourse in primary progressive aphasia: Longitudinal changes and neural correlates
Discourse in primary progressive aphasia: Longitudinal changes and neural correlates Open
Background Primary progressive aphasia (PPA) is a neurodegenerative brain condition with three variants - nonfluent (nfvPPA), logopenic (lvPPA), semantic (svPPA). At onset, nfvPPA shows atrophy in left inferior frontal gyrus with grammatic…
View article: Amygdala subregional functional connectivity in treatment-resistant depression
Amygdala subregional functional connectivity in treatment-resistant depression Open
Background: Treatment resistance impacts almost 50 % of depression patients, with amygdala dysfunction being widely implicated. fMRI studies have typically focussed on identifying whole rather than individual subregional amygdala functiona…
View article: Reduced plasma hexosylceramides in frontotemporal dementia are a biomarker of white matter integrity
Reduced plasma hexosylceramides in frontotemporal dementia are a biomarker of white matter integrity Open
INTRODUCTION Blood biomarkers are needed to facilitate new therapeutic trials and improve management of behavioral variant frontotemporal dementia (bvFTD). Since altered white matter integrity is characteristic of bvFTD, this study aimed t…
View article: Cognitive profiles in primary progressive aphasia variants: A cross-cultural Australian and Spanish investigation
Cognitive profiles in primary progressive aphasia variants: A cross-cultural Australian and Spanish investigation Open
These findings revealed an impairment in other cognitive domains beyond language in PPA. However, Spanish patients exhibited more generalized cognitive involvement despite similar demographic and neuroimaging profiles, suggesting that cult…
View article: Reduced plasma hexosylceramides in frontotemporal dementia are a biomarker of white matter integrity
Reduced plasma hexosylceramides in frontotemporal dementia are a biomarker of white matter integrity Open
INTRODUCTION Blood biomarkers are needed to facilitate new therapeutic trials and improve management of behavioural variant frontotemporal dementia (bvFTD). Since altered white matter integrity is characteristic of bvFTD, this study aimed …
View article: Differentiating sporadic frontotemporal dementia from late-onset primary psychiatric disorders
Differentiating sporadic frontotemporal dementia from late-onset primary psychiatric disorders Open
Sporadic behavioural variant frontotemporal dementia (bvFTD) is often misdiagnosed as late-onset primary psychiatric disorder (PPD) due to overlapping symptoms and lack of biomarkers. We aimed to identify clinical features that distinguish…
View article: Serum neurofilament light is superior to glial fibrillary acidic protein to distinguish sporadic frontotemporal dementia from late-onset primary psychiatric disorders: a retrospective DIPPA-FTD study
Serum neurofilament light is superior to glial fibrillary acidic protein to distinguish sporadic frontotemporal dementia from late-onset primary psychiatric disorders: a retrospective DIPPA-FTD study Open
Background Sporadic behavioural variant frontotemporal dementia (bvFTD) is often misdiagnosed as late-onset primary psychiatric disorder (PPD). Previous research in small sample sizes has shown that neurofilament light (NfL) and glial fibr…
View article: Differentiating Sporadic behavioural variant Frontotemporal Dementia from late‐onset Primary Psychiatric Disorders: the DIPPA‐FTD study
Differentiating Sporadic behavioural variant Frontotemporal Dementia from late‐onset Primary Psychiatric Disorders: the DIPPA‐FTD study Open
Background Sporadic bvFTD is often misdiagnosed as a primary psychiatric disorder (PPD) due to overlapping clinical features and lack of reliable biomarkers. The multi‐centre study DIPPA‐FTD aims to develop diagnostic‐ and prognostic ‐ alg…
View article: Amygdala subregional functional connectivity in Treatment-Resistant Depression
Amygdala subregional functional connectivity in Treatment-Resistant Depression Open
Background Treatment resistance impacts almost 50% of depression patients, with amygdala dysfunction being widely implicated. The amygdala is a complex amalgamation of subnuclei with diverse functions but fMRI studies have typically focuss…
View article: Clinical and cortical trajectories in non-fluent primary progressive aphasia and Alzheimer’s disease: A role for emotion processing
Clinical and cortical trajectories in non-fluent primary progressive aphasia and Alzheimer’s disease: A role for emotion processing Open
Our results show divergent clinical courses in nfvPPA and lvPPA, with rapid cognitive and neural deterioration in lvPPA and emotion processing decline in both groups and support the concurrent assessment of cognition and emotion processing…
View article: Longitudinal volumetric changes in amygdala subregions in frontotemporal dementia
Longitudinal volumetric changes in amygdala subregions in frontotemporal dementia Open
Amygdala atrophy has been found in frontotemporal dementia (FTD), yet the specific changes of its subregions across different FTD phenotypes remain unclear. The aim of this study was to investigate the volumetric alterations of the amygdal…
View article: Rationale and Design of the “DIagnostic and Prognostic Precision Algorithm for behavioral variant Frontotemporal Dementia” (DIPPA-FTD) Study: A Study Aiming to Distinguish Early Stage Sporadic FTD from Late-Onset Primary Psychiatric Disorders
Rationale and Design of the “DIagnostic and Prognostic Precision Algorithm for behavioral variant Frontotemporal Dementia” (DIPPA-FTD) Study: A Study Aiming to Distinguish Early Stage Sporadic FTD from Late-Onset Primary Psychiatric Disorders Open
Background: The behavioral variant of frontotemporal dementia (bvFTD) is very heterogeneous in pathology, genetics, and disease course. Unlike Alzheimer’s disease, reliable biomarkers are lacking and sporadic bvFTD is often misdiagnosed as…
View article: Apathy, empathy and depression in Alzheimer’s disease and frontotemporal dementia: Examining the constructs and white matter correlates
Apathy, empathy and depression in Alzheimer’s disease and frontotemporal dementia: Examining the constructs and white matter correlates Open
Background Apathy and reduced empathy are commonly observed in Alzheimer’s disease (AD) and the core features of behavioural‐variant frontotemporal dementia (bvFTD). Depression is also prevalent in these syndromes. Recent work has proposed…
View article: Visual rating scales of atrophy to differentiate Frontotemporal dementia from Primary psychiatric disorder: results from DIPPA study
Visual rating scales of atrophy to differentiate Frontotemporal dementia from Primary psychiatric disorder: results from DIPPA study Open
Background Adult‐onset behavioral changes and altered executive functioning are frequently caused by behavioural variant of Frontotemporal dementia (bvFTD) or primary psychiatric disorders (PPD) which overlap in terms of clinical presentat…
View article: Trajectories of white matter degeneration in frontotemporal dementia: new insights using fixel‐based analysis
Trajectories of white matter degeneration in frontotemporal dementia: new insights using fixel‐based analysis Open
Background The three clinical presentations of frontotemporal dementia (FTD), behavioral‐variant FTD (bvFTD), progressive non‐fluent aphasia (PNFA), and semantic dementia (SD), are caused by abnormal aggregation of protein pathologies and …
View article: Contrasting longitudinal changes in amygdala integrity in early Alzheimer’s disease and frontotemporal dementia subtypes
Contrasting longitudinal changes in amygdala integrity in early Alzheimer’s disease and frontotemporal dementia subtypes Open
Background The amygdala is a complex and heavily connected subcortical brain structure. It plays a central role in regulating social, emotional and cognitive processes. Amygdala atrophy has been previously reported in Alzheimer’s disease (…
View article: Visual rating scales of atrophy to differentiate Frontotemporal dementia from Primary psychiatric disorder: results from DIPPA study
Visual rating scales of atrophy to differentiate Frontotemporal dementia from Primary psychiatric disorder: results from DIPPA study Open
Background Adult‐onset behavioral changes and altered executive functioning are frequently caused by behavioural variant of Frontotemporal dementia (bvFTD) or primary psychiatric disorders (PPD) which overlap in terms of clinical presentat…
View article: Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations
Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations Open
Heterozygous mutations in the GRN gene and hexanucleotide repeat expansions in C9orf72 are the two most common genetic causes of Frontotemporal Dementia (FTD) with TDP-43 protein inclusions. The triggers for neurodegeneration in FTD with G…
View article: Shorter disease duration in females with sporadic frontotemporal dementia
Shorter disease duration in females with sporadic frontotemporal dementia Open
Background Previous reported sex differences on disease duration (DD) of frontotemporal dementia (FTD) have been inconsistent and lack the comparison between genetic and sporadic FTD. Our aim was to study the difference in disease duration…
View article: Examining the presence and nature of delusions in Alzheimer's disease and frontotemporal dementia syndromes
Examining the presence and nature of delusions in Alzheimer's disease and frontotemporal dementia syndromes Open
Objectives Abnormal beliefs and delusions have been reported in some people with dementia, however, the prevalence of delusions, and their neurocognitive basis has been underexplored. This study aimed to examine the presence, severity, con…
View article: Differences in Sex Distribution Between Genetic and Sporadic Frontotemporal Dementia
Differences in Sex Distribution Between Genetic and Sporadic Frontotemporal Dementia Open
Background: Reported sex distributions differ between frontotemporal dementia (FTD) cohorts. Possible explanations are the evolving clinical criteria of FTD and its subtypes and the discovery of FTD causal genetic mutations that has result…
View article: Brain changes underlying progression of speech motor programming impairment
Brain changes underlying progression of speech motor programming impairment Open
Aquired apraxia of speech is a disorder that impairs speech production, despite intact peripheral neuromotor function. Its pathomechanism remains to be established. Neurodegenerative lesion models provide an unequalled opportunity to explo…
View article: Interactions between decision-making and emotion in behavioral-variant frontotemporal dementia and Alzheimer’s disease
Interactions between decision-making and emotion in behavioral-variant frontotemporal dementia and Alzheimer’s disease Open
Negative and positive emotions are known to shape decision-making toward more or less impulsive responses, respectively. Decision-making and emotion processing are underpinned by shared brain regions including the ventromedial prefrontal c…