Ramón Martínez‐Mármol
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View article: OSP-1 protects neurons from autophagic cell death induced by acute oxidative stress
OSP-1 protects neurons from autophagic cell death induced by acute oxidative stress Open
Oxidative stress, caused by the accumulation of reactive oxygen species (ROS), is a pathological factor in several incurable neurodegenerative conditions as well as in stroke. However, our knowledge of the genetic elements that can be mani…
View article: <scp>SV2A</scp> controls the surface nanoclustering and endocytic recruitment of Syt1 during synaptic vesicle recycling
<span>SV2A</span> controls the surface nanoclustering and endocytic recruitment of Syt1 during synaptic vesicle recycling Open
Following exocytosis, the recapture of plasma membrane‐stranded vesicular proteins into recycling synaptic vesicles (SVs) is essential for sustaining neurotransmission. Surface clustering of vesicular proteins has been proposed to act as a…
View article: Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles
Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles Open
Neurotransmitter release relies on the regulated fusion of synaptic vesicles (SVs) that are tightly packed within the presynaptic bouton of neurons. The mechanism by which SVs are clustered at the presynapse, while preserving their ability…
View article: Location, location, location: Protein kinase nanoclustering for optimised signalling output
Location, location, location: Protein kinase nanoclustering for optimised signalling output Open
Protein kinases (PKs) are proteins at the core of cellular signalling and are thereby responsible for most cellular physiological processes and their regulations. As for all intracellular proteins, PKs are subjected to Brownian thermal ene…
View article: Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles
Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles Open
Neuronal communication relies on the release of neurotransmitters from various populations of synaptic vesicles. Despite displaying vastly different release probabilities and mobilities, the reserve and recycling pool of vesicles co-exist …
View article: Location, Location, Location: Protein kinase nanoclustering for optimized signalling output
Location, Location, Location: Protein kinase nanoclustering for optimized signalling output Open
Protein kinases (PKs) are proteins at the core of cellular signalling and are thereby responsible for most of the cellular physiological processes and their regulations. As for all cellular proteins, they are subjected to Brownian thermal …
View article: Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion
Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion Open
Introduction Brain connectivity requires correct axonal guidance to drive axons to their appropriate targets. This process is orchestrated by guidance cues that exert attraction or repulsion to developing axons. However, the intricacies of…
View article: VAMP2/Munc18-1 domain 3a interaction controls the nanoscale reorganization underpinning vesicular priming
VAMP2/Munc18-1 domain 3a interaction controls the nanoscale reorganization underpinning vesicular priming Open
Summary SNARE-mediated secretory vesicle (SV) exocytosis underpins neuronal communication. Munc18-1 orchestrates SNARE complex formation by controlling the opening of syntaxin-1A. How the SV-plasma membrane interface becomes fusion-compete…
View article: SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity
SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity Open
Numerous viruses use specialized surface molecules called fusogens to enter host cells. Many of these viruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can infect the brain and are associated with severe …
View article: Synapsin2a tetramerization selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles.
Synapsin2a tetramerization selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles. Open
Neurotransmitter release relies on the regulated fusion of synaptic vesicles (SVs) that are tightly packed within the presynapse of neurons. The mechanism by which SVs are anchored at the presynapse while preserving their ability to dynami…
View article: Hericerin derivatives activates a pan‐neurotrophic pathway in central hippocampal neurons converging to <scp>ERK1</scp>/2 signaling enhancing spatial memory
Hericerin derivatives activates a pan‐neurotrophic pathway in central hippocampal neurons converging to <span>ERK1</span>/2 signaling enhancing spatial memory Open
The traditional medicinal mushroom Hericium erinaceus is known for enhancing peripheral nerve regeneration through targeting nerve growth factor (NGF) neurotrophic activity. Here, we purified and identified biologically new active compound…
View article: Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles
Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles Open
Supplementary Table S1. Candidate proteins identified from the mouse hippocampus phosphoproteome and rat synaptosome analyses based on the maximum upregulated phosphorylation value (elicited by simulation) and the percentage of disordered …
View article: Surface SV2A-Syt1 nanoclusters act as a sequestration hub that limits dynamin-1 recruitment and targeting to recycling synaptic vesicles
Surface SV2A-Syt1 nanoclusters act as a sequestration hub that limits dynamin-1 recruitment and targeting to recycling synaptic vesicles Open
Following exocytosis, the recapture of plasma membrane-stranded vesicular proteins into recycling synaptic vesicles (SVs) is essential for sustaining neurotransmission. Surface clustering of vesicular proteins has been postulated as a ‘pre…
View article: Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates
Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates Open
View article: SV2A-Syt1 interaction controls surface nanoclustering and access to recycling synaptic vesicles
SV2A-Syt1 interaction controls surface nanoclustering and access to recycling synaptic vesicles Open
Summary Following exocytosis, the recapture of vesicular proteins stranded at the plasma membrane in recycling synaptic vesicles (SVs) is essential to sustain neurotransmission. Nanoclustering is emerging as a mechanism through which prote…
View article: The SARS-CoV-2 spike (S) and the orthoreovirus p15 cause neuronal and glial fusion
The SARS-CoV-2 spike (S) and the orthoreovirus p15 cause neuronal and glial fusion Open
Numerous enveloped viruses use specialized surface molecules called fusogens to enter host cells 1 . During virus replication, these fusogens decorate the host cells membrane enabling them the ability to fuse with neighboring cells, formin…
View article: Syntaxin-1 is necessary for UNC5/Netrin-1-dependent macropinocytosis and chemorepulsion
Syntaxin-1 is necessary for UNC5/Netrin-1-dependent macropinocytosis and chemorepulsion Open
Brain connectivity requires correct axonal guidance to drive axons to their appropriate targets. This process is orchestrated by guidance cues that exert attraction or repulsion to developing axons. However, the intricacies of the cellular…
View article: One Raft to Guide Them All, and in Axon Regeneration Inhibit Them
One Raft to Guide Them All, and in Axon Regeneration Inhibit Them Open
Central nervous system damage caused by traumatic injuries, iatrogenicity due to surgical interventions, stroke and neurodegenerative diseases is one of the most prevalent reasons for physical disability worldwide. During development, axon…
View article: Growth cone repulsion to Netrin-1 depends on lipid raft microdomains enriched in UNC5 receptors
Growth cone repulsion to Netrin-1 depends on lipid raft microdomains enriched in UNC5 receptors Open
During brain development, Uncoordinated locomotion 5 (UNC5) receptors control axonal extension through their sensing of the guidance molecule Netrin-1. The correct positioning of receptors into cholesterol-enriched membrane raft microdomai…
View article: Frontotemporal dementia mutant tau (P301L) locks Fyn in an open, active conformation conducive to nanoclustering
Frontotemporal dementia mutant tau (P301L) locks Fyn in an open, active conformation conducive to nanoclustering Open
Fyn is a Src kinase that controls critical signalling cascades and its postsynaptic enrichment underpins synaptotoxicity in Alzheimer’s disease (AD) and frontotemporal dementia (FTLD-tau). Previously, we found that pathogenic FTLD tau muta…
View article: Hericerin derivatives from<i>Hericium erinaceus</i>exert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memory
Hericerin derivatives from<i>Hericium erinaceus</i>exert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memory Open
The traditional medicinal mushroom Hericium erinaceus has long been known for enhancing the peripheral nerve regeneration through targeting nerve growth factor (NGF) neurotrophic activity. It was also reported to protect against ageing-dep…
View article: An Epilepsy-Associated SV2A Mutation Disrupts Synaptotagmin-1 Expression and Activity-Dependent Trafficking
An Epilepsy-Associated SV2A Mutation Disrupts Synaptotagmin-1 Expression and Activity-Dependent Trafficking Open
The epilepsy-linked gene SV2A , has a number of potential roles in the synaptic vesicle (SV) life cycle. However, how loss of SV2A function translates into presynaptic dysfunction and ultimately seizure activity is still undetermined. In t…
View article: Nystatin Regulates Axonal Extension and Regeneration by Modifying the Levels of Nitric Oxide
Nystatin Regulates Axonal Extension and Regeneration by Modifying the Levels of Nitric Oxide Open
Nystatin is a pharmacological agent commonly used for the treatment of oral, mucosal and cutaneous fungal infections. Nystatin has also been extensively applied to study the cellular function of cholesterol-enriched structures because of i…
View article: p110δ PI3-Kinase Inhibition Perturbs APP and TNFα Trafficking, Reduces Plaque Burden, Dampens Neuroinflammation, and Prevents Cognitive Decline in an Alzheimer's Disease Mouse Model
p110δ PI3-Kinase Inhibition Perturbs APP and TNFα Trafficking, Reduces Plaque Burden, Dampens Neuroinflammation, and Prevents Cognitive Decline in an Alzheimer's Disease Mouse Model Open
Alzheimer's disease (AD) is associated with the cleavage of the amyloid precursor protein (APP) to produce the toxic amyloid-β (Aβ) peptide. Accumulation of Aβ, together with the concomitant inflammatory response, ultimately leads to neuro…
View article: Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines
Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines Open
The Src kinase Fyn plays critical roles in memory formation and Alzheimer’s disease. Its targeting to neuronal dendrites is regulated by Tau via an unknown mechanism. As nanoclustering is essential for efficient signaling, we used single-m…
View article: Author response: Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines
Author response: Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The Src kinase Fyn plays critical roles in…
View article: Cholesterol Depletion Regulates Axonal Growth and Enhances Central and Peripheral Nerve Regeneration
Cholesterol Depletion Regulates Axonal Growth and Enhances Central and Peripheral Nerve Regeneration Open
Axonal growth during normal development and axonal regeneration rely on the action of many receptor signaling systems and complexes, most of them located in specialized raft membrane microdomains with a precise lipid composition. Cholester…
View article: VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular Priming
VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular Priming Open
View article: A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse
A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse Open
Axonal growth and guidance rely on correct growth cone responses to guidance cues. Unlike the signaling cascades that link axonal growth to cytoskeletal dynamics, little is known about the crosstalk mechanisms between guidance and membrane…
View article: PKC Activation Induces Ubiquitination-Dependent KV1.3 Endocytosis Mediated by Nedd4-2 Ubiquitin Ligase
PKC Activation Induces Ubiquitination-Dependent KV1.3 Endocytosis Mediated by Nedd4-2 Ubiquitin Ligase Open