Ramsay E. Beveridge
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View article: SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS IN HEALTHY VOLUNTEERS OF VENT-03, A NOVEL CGAS INHIBITOR FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS
SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS IN HEALTHY VOLUNTEERS OF VENT-03, A NOVEL CGAS INHIBITOR FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS Open
PV073 / #286 Poster Topic: AS09 - Emerging Approaches in SLE Management Background/Purpose The detection of foreign DNA by the innate immune system is a vital component of the host response to pathogens. In mammalian cells, this task is pe…
View article: Structural insight into the cGAS active site explains differences between therapeutically relevant species
Structural insight into the cGAS active site explains differences between therapeutically relevant species Open
Cyclic GMP-AMP synthase (cGAS) is an intracellular sensor of double-stranded DNA that triggers a pro-inflammatory response upon binding. The interest in cGAS as a drug discovery target has increased substantially over the past decade due t…
View article: Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model
Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model Open
The lack of selective and safe in vivo IRE1α tool molecules has limited the evaluation of IRE1α as a viable target to treat multiple myeloma. Focus on improving the physicochemical properties of a literature compound by decreasing lipophil…
View article: Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity
Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity Open
Amino-quinazoline BRaf kinase inhibitor 2 was identified from a library screen as a modest inhibitor of the unfolded protein response (UPR) regulating potential anticancer target IRE1α. A combination of crystallographic and conformational …