Qing Li
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View article: Development and validation of an interpretable machine learning model for predicting the risk of non-cardiac surgery postoperative heart failure: a multicenter study
Development and validation of an interpretable machine learning model for predicting the risk of non-cardiac surgery postoperative heart failure: a multicenter study Open
Background This study developed a machine learning model to predict postoperative heart failure (HF) risk in non-cardiac surgery patients. Methods Using data from 489 patients (109 HF cases, 380 controls), the dataset was split 8:2 into tr…
View article: SerpinA3N-APOE interaction in astrocytes exacerbates Alzheimer’s disease progression through NFκB activation
SerpinA3N-APOE interaction in astrocytes exacerbates Alzheimer’s disease progression through NFκB activation Open
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders characterized by β-amyloid (Aβ) deposition, neurofibrillary tangles, neuronal loss, and neuroinflammation. It represents a growing global health crisis. Alth…
View article: The impact of early nutritional support on in-hospital mortality in patients with sepsis caused by bacterial or viral infections: a retrospective cohort study
The impact of early nutritional support on in-hospital mortality in patients with sepsis caused by bacterial or viral infections: a retrospective cohort study Open
Early nutritional support may offer a potential survival benefit in patients with viral sepsis. Given the small size and borderline statistical significance, these findings should be interpreted with caution and require further validation …
View article: Comprehensive Analysis of Circular RNA Expression Dynamics and ceRNA Network Mechanisms During Postnatal Liver Development in Juvenile Goats
Comprehensive Analysis of Circular RNA Expression Dynamics and ceRNA Network Mechanisms During Postnatal Liver Development in Juvenile Goats Open
This study reveals the dynamic expression profile of circRNA during goat liver development, suggesting that it may regulate metabolic and immune pathways through the ceRNA mechanism, providing a new perspective on post-transcriptional regu…
View article: Macro-scale, scaffold-assisted model of the human bone marrow endosteal niche using hiPSC-vascularized osteoblastic organoids
Macro-scale, scaffold-assisted model of the human bone marrow endosteal niche using hiPSC-vascularized osteoblastic organoids Open
Endosteal bone marrow (BM) niches are crucial to sustain non-steady-state hematopoiesis but are challenging to be modeled in their cellular and molecular complexity in standardized, human settings. We report a developmentally guided approa…
View article: Research on the rock-breaking mechanism and key factors influencing ROP enhancement during marble cutting with special-shaped PDC cutters
Research on the rock-breaking mechanism and key factors influencing ROP enhancement during marble cutting with special-shaped PDC cutters Open
To improve the understanding of key drilling parameters affecting the efficiency of the shaped polycrystalline diamond compact (PDC) bits during drilling operations in marble formations, this study conducted experimental investigations to …
View article: Elucidating the phytochemical profile of Sophorae Flavescentis Radix-Astragali Radix herb pair: an integrated LC-QTOF-MS/MS, pharmacological activity, and network pharmacology study on anti-hepatocellular carcinoma effects
Elucidating the phytochemical profile of Sophorae Flavescentis Radix-Astragali Radix herb pair: an integrated LC-QTOF-MS/MS, pharmacological activity, and network pharmacology study on anti-hepatocellular carcinoma effects Open
Background Hepatocellular carcinoma (HCC) remains refractory because recurrence, drug resistance and systemic toxicity limit current therapeutics. The traditional herb pair Sophorae Flavescentis Radix-Astragali Radix (SF-AR) is reputed to …
View article: Efgartigimod non-responders after the first treatment cycle in generalized myasthenia gravis: a retrospective analysis of predictive factors
Efgartigimod non-responders after the first treatment cycle in generalized myasthenia gravis: a retrospective analysis of predictive factors Open
Objective This study aimed to identify predictors of suboptimal response to efgartigimod in patients with generalized myasthenia gravis (gMG). Methods In this single-center retrospective study, 35 gMG patients treated with efgartigimod wer…
View article: Eating-related distress profiles and spiritual well-being in patients with advanced cancer receiving chemotherapy: A latent profile analysis
Eating-related distress profiles and spiritual well-being in patients with advanced cancer receiving chemotherapy: A latent profile analysis Open
Patients with advanced cancer receiving chemotherapy exhibit heterogeneity in ERD, influenced by sociodemographic, clinical, and psychological factors. SWB varied significantly across ERD profiles. Tailored nutritional, psychological, and …
View article: Impact of different production systems on the slaughter performance and meat quality of gayal (Bos frontalis)
Impact of different production systems on the slaughter performance and meat quality of gayal (Bos frontalis) Open
Objective The aim of this study was to evaluate the influence of different production systems, including low-altitude indoor feeding, high-altitude indoor feeding, and high-altitude grazing, on the slaughter performance and meat quality of…
View article: A Study on the Effectiveness of Metacognitive Training in Treating Negative Symptoms of Different Subtypes of Schizophrenia
A Study on the Effectiveness of Metacognitive Training in Treating Negative Symptoms of Different Subtypes of Schizophrenia Open
MCT can improve the clinical symptoms and functions of patients with schizophrenia, especially in the DE factor characterized by conceptual disorganization and stereotyped thinking, and the SA factor prominent in suspiciousness/persecution…
View article: Segmental Odontomaxillary Dysplasia:Clinical Features And Molecular Insights
Segmental Odontomaxillary Dysplasia:Clinical Features And Molecular Insights Open
Aim or purpose: To investigate the clinical features and molecular mechanisms underlying segmental odontomaxillary dysplasia (SOD). Materials and methods: A systematic literature review was conducted on SOD cases, sourcing data from PubMed…
View article: Synergistic Cemof Nanoplatform For Oscc Radiosensitization And Immune Microenvironment Remodeling
Synergistic Cemof Nanoplatform For Oscc Radiosensitization And Immune Microenvironment Remodeling Open
Aim or purpose: To address the dual challenges of radiotherapy resistance and immunosuppressive microenvironments in oral squamous cell carcinoma (OSCC), this study developed a cerium-based metal-organic framework (CeMOF) nanoplatform inte…
View article: Etomidate Improves Antitumor Immunity by Suppressing PD-L1 Expression in Hepatocellular Carcinoma Cells
Etomidate Improves Antitumor Immunity by Suppressing PD-L1 Expression in Hepatocellular Carcinoma Cells Open
These findings support the hypothesis that etomidate enhances antitumor immunity and boosts the therapeutic efficacy of immune checkpoint blockade, thereby laying a theoretical foundation for precision immunotherapy in HCC.
View article: The value of C-TIRADS combined with multidimensional indicators in the diagnosis of papillary thyroid carcinoma
The value of C-TIRADS combined with multidimensional indicators in the diagnosis of papillary thyroid carcinoma Open
The integrated model based on C-TIRADS classification combined with metabolic function parameters and inflammatory indicators has good efficacy in risk assessment of PTC, and can provide an objective quantitative tool for individual diagno…
View article: Two <i>Isatis</i> Genomes Reveal the Biosynthesis and Evolutionary Origin of Indigo in Plants
Two <i>Isatis</i> Genomes Reveal the Biosynthesis and Evolutionary Origin of Indigo in Plants Open
Indigo, a plant-originated blue dye, has a long and well-documented history of extensive human use. The Isatis genus has long been a key source for indigo production, however, the biosynthetic pathway responsible for indigo within Isatis h…
View article: Efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor as a support for chemotherapy for gestational trophoblastic neoplasia: a propensity score matching analysis
Efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor as a support for chemotherapy for gestational trophoblastic neoplasia: a propensity score matching analysis Open
Background Gestational trophoblastic neoplasia (GTN) is a highly malignant tumor that can be effectively treated with chemotherapy alone. Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is used to reverse the adverse effe…
View article: Neonatal encephalopathy due to birth asphyxia and trauma: global trends and disparities
Neonatal encephalopathy due to birth asphyxia and trauma: global trends and disparities Open
Background Neonatal encephalopathy due to birth asphyxia and trauma (NE-BAT) is a leading cause of neonatal mortality and long-term neurodevelopmental disabilities, particularly in low- and middle-income regions. Methods Using the Global B…
View article: WSB-1 regulates DNA repair and the response to DNA damage response inhibitors in breast cancer
WSB-1 regulates DNA repair and the response to DNA damage response inhibitors in breast cancer Open
Tumour hypoxia is a poor prognostic factor and linked with metastatic spread and treatment resistance in most solid tumours, including breast cancer. We previously showed hypoxia-regulated E3 ligase WSB-1s association with poor prognosis i…
View article: Porphyridium purpureum culture extract as an ecologically safe agent against PM2.5 - induced skin toxicity
Porphyridium purpureum culture extract as an ecologically safe agent against PM2.5 - induced skin toxicity Open
Seaweed derivatives have demonstrated various biological activities, including anti-inflammatory and antiviral activities. Porphyridium purpureum (P. purpureum) polysaccharide were analyzed for their composition and barrier and antipruriti…
View article: Diagnostic values of diffusion-weighted imaging and dynamic contrast-enhanced MRI in the pathological grading of adenoid cystic carcinoma
Diagnostic values of diffusion-weighted imaging and dynamic contrast-enhanced MRI in the pathological grading of adenoid cystic carcinoma Open
Not applicable.
View article: Changes in Umami-Enhancing Nucleotides in White Mullet (Ophiocephalus argus var. Kimnra) Meat Stored at Ice Temperature
Changes in Umami-Enhancing Nucleotides in White Mullet (Ophiocephalus argus var. Kimnra) Meat Stored at Ice Temperature Open
The aim of this study was to investigate the effect of ice-temperature (IT) storage on the umami-enhancing nucleotide content in white mullet (Ophiocephalus argus var. Kimnra) meat. White mullet dorsal muscle was used as the raw material, …