Ran Nakashima
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View article: Roles of JAK-STAT signaling and granulocyte–macrophage colony-stimulating factor in the development of osteitis and bone microstructure changes in rheumatoid arthritis
Roles of JAK-STAT signaling and granulocyte–macrophage colony-stimulating factor in the development of osteitis and bone microstructure changes in rheumatoid arthritis Open
GM-CSF drives osteitis and BMCs by increasing granulocyte‒macrophage-lineage cells and OCPs and promoting osteoclast differentiation. Targeting GM-CSF is a potential therapeutic strategy to prevent early radiographic changes in RA.
View article: Immune checkpoint inhibitor-induced myocarditis and multiple adverse events with pre-existing rheumatoid arthritis: a case report and literature review
Immune checkpoint inhibitor-induced myocarditis and multiple adverse events with pre-existing rheumatoid arthritis: a case report and literature review Open
Immune checkpoint inhibitors (ICIs) can trigger immune-related adverse events (irAEs) and rheumatoid arthritis (RA) reactivation in cancer patients with pre-existing RA. Studies indicate RA reactivation occurs in approximately 50% of these…
View article: Differences in Organ Damage Based on Age at Onset in Idiopathic Inflammatory Myopathies: A Retrospective Multicenter MYKO Study
Differences in Organ Damage Based on Age at Onset in Idiopathic Inflammatory Myopathies: A Retrospective Multicenter MYKO Study Open
Objective To analyze the influence of age of the onset on myositis organ damage and to identify the factors influencing myositis organ damage, as clinical manifestations of myopathies differ by the age of onset and the background of patien…
View article: Clinicopathological features of anti-HMGCR and anti-SRP myopathies that do not satisfy the EULAR/ACR criteria of inflammatory myopathies
Clinicopathological features of anti-HMGCR and anti-SRP myopathies that do not satisfy the EULAR/ACR criteria of inflammatory myopathies Open
Objectives The clinicopathological features of immune-mediated necrotizing myopathy (IMNM) sometimes mimic muscular dystrophy, complicating accurate diagnosis. The European League Against Rheumatism (EULAR)/American College of Rheumatology…
View article: The role of multicriteria decision analysis in the development of candidate classification criteria for antisynthetase syndrome: analysis from the CLASS project
The role of multicriteria decision analysis in the development of candidate classification criteria for antisynthetase syndrome: analysis from the CLASS project Open
The MCDA-driven candidate classification criteria were consistent with published ASSD literature and yielded high accuracy and validity.
View article: Memory B cells and their transcriptomic profiles associated with belimumab resistance in systemic lupus erythematosus in the maintenance phase
Memory B cells and their transcriptomic profiles associated with belimumab resistance in systemic lupus erythematosus in the maintenance phase Open
The factors contributing to the treatment efficacy of belimumab in patients with systemic lupus erythematosus (SLE) in the maintenance phase are unknown. Here, we collected blood samples from patients with SLE (n=44) treated with belimumab…
View article: The Association of Anti-dsDNA Antibodies with Patient-reported Outcomes of Patients with Systemic Lupus Erythematosus in a Two-consecutive Year Prospective Study.
The Association of Anti-dsDNA Antibodies with Patient-reported Outcomes of Patients with Systemic Lupus Erythematosus in a Two-consecutive Year Prospective Study. Open
PROs at a time point and changes were difficult to be captured by anti-dsDNA. It is desirable to explore objective laboratory measures to evaluate PROs.
View article: Anti-interferon gamma-inducible protein 16 antibodies: Identification of a novel autoantigen in idiopathic interstitial pneumonia and its clinical characteristics based on a multicenter cohort study
Anti-interferon gamma-inducible protein 16 antibodies: Identification of a novel autoantigen in idiopathic interstitial pneumonia and its clinical characteristics based on a multicenter cohort study Open
Autoantibodies are detected in idiopathic interstitial pneumonias (IIPs) without a clear connective tissue disease diagnosis, and their clinical significance is unclear. This study aimed to identify a novel autoantibody in IIPs. We screene…
View article: Idiopathic Inflammatory Myopathies-Associated Interstitial Lung Disease in Adults
Idiopathic Inflammatory Myopathies-Associated Interstitial Lung Disease in Adults Open
Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune diseases characterized by muscle involvement and various extramuscular manifestations. Interstitial lung disease (ILD) is one of the most common extramuscular…
View article: Development of an immunoprecipitation assay for detecting anti‐3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase autoantibodies using a non‐radioactive biotinylated recombinant protein
Development of an immunoprecipitation assay for detecting anti‐3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase autoantibodies using a non‐radioactive biotinylated recombinant protein Open
Objectives A variety of myositis‐specific autoantibodies have been identified in sera from patients with idiopathic inflammatory myopathies, and they play a crucial role in tailoring personalized disease management. In particular, autoanti…
View article: Perspectives in the treatment of interstitial lung disease accompanied with anti‐melanoma differentiation‐associated gene 5‐positive dermatomyositis
Perspectives in the treatment of interstitial lung disease accompanied with anti‐melanoma differentiation‐associated gene 5‐positive dermatomyositis Open
The establishment of an effective treatment for rapidly progressive interstitial lung disease (RP-ILD) accompanied with anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis is important.1-3 As the disease is rare…
View article: Anti-aminoacyl tRNA synthetase antibodies showing the discrepancy between enzyme-linked immunosorbent assay and RNA-immunoprecipitation
Anti-aminoacyl tRNA synthetase antibodies showing the discrepancy between enzyme-linked immunosorbent assay and RNA-immunoprecipitation Open
Anti-aminoacyl-tRNA synthetase (ARS) antibodies are myositis-specific antibodies associated with anti-synthetase syndrome (ASSD). Some patients are positive for anti-ARS antibodies on enzyme-linked immunosorbent assay (ELISA) but negative …
View article: Impaired health-related quality of life in idiopathic inflammatory myopathies: a cross-sectional analysis from the COVAD-2 e-survey
Impaired health-related quality of life in idiopathic inflammatory myopathies: a cross-sectional analysis from the COVAD-2 e-survey Open
Objectives To investigate health-related quality of life in patients with idiopathic inflammatory myopathies (IIMs) compared with those with non-IIM autoimmune rheumatic diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs) and with…
View article: Coalition for Health and Gender Equity (CHANGE)—a protocol for a global cross-sectional survey of health and gender equity in rheumatology
Coalition for Health and Gender Equity (CHANGE)—a protocol for a global cross-sectional survey of health and gender equity in rheumatology Open
Objectives The primary aim of the CHANGE survey is to determine the current state of gender equity within rheumatology, and secondarily, to review the physician perspective on bullying, harassment and equipoise of opportunities within rheu…
View article: Comparison of chest radiological findings between coronavirus disease 2019 pneumonia and anti-melanoma differentiation-associated gene 5 antibody- positive interstitial pneumonia by artificial intelligence-based quantitative computed tomography image analysis
Comparison of chest radiological findings between coronavirus disease 2019 pneumonia and anti-melanoma differentiation-associated gene 5 antibody- positive interstitial pneumonia by artificial intelligence-based quantitative computed tomography image analysis Open
Background Coronavirus disease 2019 (COVID-19) pneumonia and anti-melanoma differentiation-associated gene 5 antibody-positive interstitial pneumonia (MDA5-IP) share many similarities; however, the treatment and management of the two disea…
View article: Pathogenicity of IgG-Fc desialylation and its association with Th17 cells in an animal model of systemic lupus erythematosus
Pathogenicity of IgG-Fc desialylation and its association with Th17 cells in an animal model of systemic lupus erythematosus Open
Objectives Decreased sialylation of IgG-Fc glycans has been reported in autoimmune diseases, but its role in systemic lupus erythematosus (SLE) is not fully understood. In this study, we examined the pathogenicity of IgG desialylation and …
View article: POS0142 THE ASSOCIATION OF AUTOANTIBODIES WITH CLINICAL MANIFESTATIONS AND LONG-TERM REMISSIONS IN COMPARISON WITH JUVENILE- AND ADULT-ONSET IDIOPATHIC INFLAMMATORY MYOPATHIES
POS0142 THE ASSOCIATION OF AUTOANTIBODIES WITH CLINICAL MANIFESTATIONS AND LONG-TERM REMISSIONS IN COMPARISON WITH JUVENILE- AND ADULT-ONSET IDIOPATHIC INFLAMMATORY MYOPATHIES Open
Background The associations of myositis-specific autoantibodies (MSAs) and myositis-associated autoantibodies (MAAs) with clinical features and remission in idiopathic inflammatory myopathy (IIM) are different between those of juvenile-ons…
View article: OP0241 PROGNOSIS OF PATIENTS WITH SYSTEMIC SCLEROSIS-RELATED INTERSTITIAL LUNG DISEASE AFTER THE LUNG TRANSPLANTATION: A RETROSPECTIVE STUDY
OP0241 PROGNOSIS OF PATIENTS WITH SYSTEMIC SCLEROSIS-RELATED INTERSTITIAL LUNG DISEASE AFTER THE LUNG TRANSPLANTATION: A RETROSPECTIVE STUDY Open
Background Interstitial lung disease (ILD) is a major complication of systemic sclerosis (SSc) and is associated with mortality [1]. Lung transplantation (LT) is a therapeutic option for advanced SSc-associated ILD (SSc-ILD). However, ther…