Rong Wu
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View article: Multimode MALDI-MSI deciphers matrine-induced metabolic reprogramming in prostate cancer xenografts: spatial mapping of low-molecular-weight compound alterations
Multimode MALDI-MSI deciphers matrine-induced metabolic reprogramming in prostate cancer xenografts: spatial mapping of low-molecular-weight compound alterations Open
Background Matrine, a bioactive isoquinoline alkaloid, exhibits antitumor efficacy by modulating multiple signaling pathways to suppress cancer cell proliferation, migration and invasion. However, its metabolic regulatory mechanisms in pro…
View article: IDEDNIK syndrome: a newly recognized rare genetic disorder caused by AP1S1 and AP1B1 mutations
IDEDNIK syndrome: a newly recognized rare genetic disorder caused by AP1S1 and AP1B1 mutations Open
IDEDNIK syndrome (formerly MEDNIK syndrome, OMIM #609313) is a rare autosomal recessive neurocutaneous disorder characterized by dysregulated copper metabolism and multisystem involvement. The primary causative gene, AP1S1 , encodes the σ1…
View article: Combining mitochondrial proteomes and Mendelian randomization to identify novel therapeutic targets for diabetic nephropathy
Combining mitochondrial proteomes and Mendelian randomization to identify novel therapeutic targets for diabetic nephropathy Open
Diabetic nephropathy (DN) is a common microvascular complication of diabetes. Mitochondrial dysfunction in the kidney caused by diabetes has previously been linked to the pathogenesis of DN. By mass spectrometry, we identified characterist…
View article: High‐Throughput Production of Gelatin‐Based Touch‐Spun Nanofiber for Biomedical Applications
High‐Throughput Production of Gelatin‐Based Touch‐Spun Nanofiber for Biomedical Applications Open
Nanofiber production techniques have become increasingly important due to their wide range of applications. However, the complex design of the setup and difficulty in scaling up to high production rate have limited the industrial applicabi…
View article: Temperature Separation in a Vortex Tube and convection driven by vorticity
Temperature Separation in a Vortex Tube and convection driven by vorticity Open
Why the temperature gradient in the vortex tube deviates significantly from the adiabatic gradient is a very important but unresolved issue in vortex tube research. In compressible fluids, the vorticity of a fluid parcel that is different …
View article: The Interaction between Solar Convection and Rotation
The Interaction between Solar Convection and Rotation Open
The rotational energy of a fluid parcel changes during isotropic expansion or compression. In solar convection, rotation absorbs energy from convection and inhibits it, causing the motion of fluid parcels larger than a critical size to bec…
View article: Supplemental Figure 4 from CD24<sup>+</sup> Ovarian Cancer Cells Are Enriched for Cancer-Initiating Cells and Dependent on JAK2 Signaling for Growth and Metastasis
Supplemental Figure 4 from CD24<sup>+</sup> Ovarian Cancer Cells Are Enriched for Cancer-Initiating Cells and Dependent on JAK2 Signaling for Growth and Metastasis Open
Supplemental Figure 4. Confirmation of JAK2 depletion by siRNA
View article: Supplemental Figure 5 from CD24<sup>+</sup> Ovarian Cancer Cells Are Enriched for Cancer-Initiating Cells and Dependent on JAK2 Signaling for Growth and Metastasis
Supplemental Figure 5 from CD24<sup>+</sup> Ovarian Cancer Cells Are Enriched for Cancer-Initiating Cells and Dependent on JAK2 Signaling for Growth and Metastasis Open
Supplemental Figure 5. FACS isolation strategy and purity of sort
View article: Supplemental Figure 4 from CD24<sup>+</sup> Ovarian Cancer Cells Are Enriched for Cancer-Initiating Cells and Dependent on JAK2 Signaling for Growth and Metastasis
Supplemental Figure 4 from CD24<sup>+</sup> Ovarian Cancer Cells Are Enriched for Cancer-Initiating Cells and Dependent on JAK2 Signaling for Growth and Metastasis Open
Supplemental Figure 4. Confirmation of JAK2 depletion by siRNA
View article: Supplemental Figure 5 from CD24<sup>+</sup> Ovarian Cancer Cells Are Enriched for Cancer-Initiating Cells and Dependent on JAK2 Signaling for Growth and Metastasis
Supplemental Figure 5 from CD24<sup>+</sup> Ovarian Cancer Cells Are Enriched for Cancer-Initiating Cells and Dependent on JAK2 Signaling for Growth and Metastasis Open
Supplemental Figure 5. FACS isolation strategy and purity of sort
View article: Supplementary Methods from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts
Supplementary Methods from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts Open
Supplementary Methods
View article: Supplementary Methods from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts
Supplementary Methods from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts Open
Supplementary Methods
View article: Supplementary Figure 2 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma
Supplementary Figure 2 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma Open
PDF file - 111K, Characterization of PI3K/Akt/mTOR and Erk signaling pathway regulation in human ovarian cancer cells after treatment with mTOR inhibitor rapamycin. Immunoblots showing dose-dependent effect of rapamycin (0.01 - 100nM) on p…
View article: Supplementary Figure S4 from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts
Supplementary Figure S4 from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts Open
Figure S4 shows correlation of RNA expression in human and mouse HGSCs using a subset of genes
View article: Supplementary Figure S4 from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts
Supplementary Figure S4 from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts Open
Figure S4 shows correlation of RNA expression in human and mouse HGSCs using a subset of genes
View article: Supplementary Figure 2 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma
Supplementary Figure 2 from Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma Open
PDF file - 111K, Characterization of PI3K/Akt/mTOR and Erk signaling pathway regulation in human ovarian cancer cells after treatment with mTOR inhibitor rapamycin. Immunoblots showing dose-dependent effect of rapamycin (0.01 - 100nM) on p…
View article: Supplementary Figure S3 from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts
Supplementary Figure S3 from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts Open
Figure S3 shows mouse RNA-seq data from normal ovaries, oviducts, and mouse tumors
View article: Supplementary Figure S3 from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts
Supplementary Figure S3 from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts Open
Figure S3 shows mouse RNA-seq data from normal ovaries, oviducts, and mouse tumors
View article: Supplementary Figure S2 from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts
Supplementary Figure S2 from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts Open
Figure S2 shows Sanger sequencing confirmation of somatic mutations in BPRN tumors
View article: Supplementary Figure S2 from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts
Supplementary Figure S2 from Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human Counterparts Open
Figure S2 shows Sanger sequencing confirmation of somatic mutations in BPRN tumors
View article: Efficient, Breathable, and Compostable Multilayer Air Filter Material Prepared from Plant-Derived Biopolymers
Efficient, Breathable, and Compostable Multilayer Air Filter Material Prepared from Plant-Derived Biopolymers Open
State-of-art face masks and respirators are fabricated as single-use devices using microfibrous polypropylene fabrics, which are challenging to be collected and recycled at a community scale. Compostable face masks and respirators can offe…
View article: Synthesis of Acrylate Dual-Tone Resists and the Effect of Their Molecular Weight on Lithography Performance and Mechanism: An Investigation
Synthesis of Acrylate Dual-Tone Resists and the Effect of Their Molecular Weight on Lithography Performance and Mechanism: An Investigation Open
Acrylate photoresists have gained considerable attention in recent years owing to their high resolution, high sensitivity, and versality. In this work, a series of thermally stable copolymers are synthesized by introducing an isobornyl gro…
View article: Design of Ti-Zr-Ta Alloys with Low Elastic Modulus Reinforced by Spinodal Decomposition
Design of Ti-Zr-Ta Alloys with Low Elastic Modulus Reinforced by Spinodal Decomposition Open
On the basis of the ternary phase diagram of Ti-Zr-Ta alloys and the d-electron orbital theory, the alloys with the nominal compositions of Ti-40Zr-20Ta (TZT1), Ti-35Zr-20Ta (TZT2) and Ti-30Zr-20Ta (TZT3) (in atom composition) were designe…
View article: Identification of Cell Subpopulations and Interactive Signaling Pathways From a Single-Cell RNA Sequencing Dataset in Osteosarcoma: A Comprehensive Bioinformatics Analysis
Identification of Cell Subpopulations and Interactive Signaling Pathways From a Single-Cell RNA Sequencing Dataset in Osteosarcoma: A Comprehensive Bioinformatics Analysis Open
Osteosarcoma is a type of highly aggressive bone tumor arising from primitive cells of mesenchymal origin in adults and is associated with a high rate of tumor relapse. However, there is an urgent need to clarify the molecular mechanisms u…
View article: Values, Motives, and Organic Food Consumption in China: A Moderating Role of Perceived Uncertainty
Values, Motives, and Organic Food Consumption in China: A Moderating Role of Perceived Uncertainty Open
The present research attempts to understand the importance of altruistic and egoistic values in determining consumers’ motives and intention to purchase organic foods. Using the face-to-face survey approach, a total of 1,067 responses were…
View article: Anisotropic wetting surfaces machined by diamond tool with tips microstructured by focused ion beam
Anisotropic wetting surfaces machined by diamond tool with tips microstructured by focused ion beam Open
In recent years, there has been an increasing interest in methods to fabricate hydrophobic surfaces. Hydrophobic surfaces have been used in multiple applications in microfluidic devices to control fluid flow, as self-cleaning surfaces and …