Ran Zhuang
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View article: Development and validation of a novel critical risk stratification scale for hemorrhagic fever with renal syndrome patients with Hantaan virus infection
Development and validation of a novel critical risk stratification scale for hemorrhagic fever with renal syndrome patients with Hantaan virus infection Open
We developed and validated the first prediction model for critically-illed HFRS patients which will aid clinicians in clinical decision-making.
View article: Pretreatment with Astragalus polysaccharide alleviates heat stroke–induced intestinal injury in mice
Pretreatment with Astragalus polysaccharide alleviates heat stroke–induced intestinal injury in mice Open
Background Heat stroke (HS) is a life-threatening illness. For HS, prevention is more important than treatment. Astragalus polysaccharides (APS), a major active ingredient of Astragalus membranaceus (Fisch.) Bunge, has multiple bioactiviti…
View article: Dietary metabolic energy/lysine ratios improve the yolk color and Hastelloy unit without affecting the egg performance of brown laying hens
Dietary metabolic energy/lysine ratios improve the yolk color and Hastelloy unit without affecting the egg performance of brown laying hens Open
This experiment evaluated the impact of varying ratios of dietary metabolic energy: lysine (ME: Lys) in the diet on egg production, egg quality, and feed intake of laying hens. A total of 432 Hy-line brown laying hens, aged 55 wk, were rea…
View article: Hantaan virus-derived peptides that stabilize HLA-E could abrogate inhibition of CD56dimNKG2A+ NK cells
Hantaan virus-derived peptides that stabilize HLA-E could abrogate inhibition of CD56dimNKG2A+ NK cells Open
NK cells could participate in the pathogenesis process of virus infectious diseases through the inhibitory receptor CD94/NKG2A interacting with HLA-E/virus-derived peptide complex. However, the effects and mechanisms of NKG2A-HLA-E axis-me…
View article: Apaf-1 is an evolutionarily conserved DNA sensor that switches the cell fate between apoptosis and inflammation
Apaf-1 is an evolutionarily conserved DNA sensor that switches the cell fate between apoptosis and inflammation Open
Apoptotic protease activating factor 1 (Apaf-1) was traditionally defined as a scaffold protein in mammalian cells for assembling a caspase activation platform known as the ‘apoptosome’ after its binding to cytochrome c . Although Apaf-1 s…
View article: Hantaan virus-derived peptides that stabilize HLA-E could abrogate inhibition of CD56<sup>dim</sup>NKG2A<sup>+</sup>NK cells
Hantaan virus-derived peptides that stabilize HLA-E could abrogate inhibition of CD56<sup>dim</sup>NKG2A<sup>+</sup>NK cells Open
NK cells could participate in the pathogenesis process of virus infectious diseases through the inhibitory receptor CD94/NKG2A interacting with HLA-E/virus-derived peptide complex. However, the effects and mechanisms of NKG2A-HLA-E axis-me…
View article: Salvianolic acid B improves the microcirculation in a mouse model of sepsis through a mechanism involving the platelet receptor CD226
Salvianolic acid B improves the microcirculation in a mouse model of sepsis through a mechanism involving the platelet receptor CD226 Open
Background and Purpose Salvianolic acid B (SalB) demonstrates diverse clinical applications, particularly in cardiovascular and cerebral protection. This study primarily investigated the effects of SalB on sepsis. Experimental Approach The…
View article: HMGB1 released from pyroptotic vascular endothelial cells promotes immune disorders in exertional heatstroke
HMGB1 released from pyroptotic vascular endothelial cells promotes immune disorders in exertional heatstroke Open
The release of HMGB1 from pyroptotic endothelial cells after EHS promotes pyroptosis of macrophages and systemic inflammatory response, and HMGB1-neutralizing antibody therapy has good application prospects for EHS.
View article: Vibration signal acquisition and extraction for cutter wear monitoring
Vibration signal acquisition and extraction for cutter wear monitoring Open
The cutter wear state is key in manufacturing. During the machining, the vibration signal of the tool spindle will change with the increase of cutter wear, which provides an effective method for cutter wear monitoring. However, due to the …
View article: Alterations in CX3CL1 Levels and Its Role in Viral Pathogenesis
Alterations in CX3CL1 Levels and Its Role in Viral Pathogenesis Open
CX3CL1, also named fractalkine or neurotactin, is the only known member of the CX3C chemokine family that can chemoattract several immune cells. CX3CL1 exists in both membrane-anchored and soluble forms, with each mediating distinct biolog…
View article: Changes and Functions of CX3CL1 in Viral Infection and Associated Diseases
Changes and Functions of CX3CL1 in Viral Infection and Associated Diseases Open
CX3CL1, also named fractalkine or neurotactin, the only known member of the CX3C chemokine family that can chemoattract several immune cells. CX3CL1 exists in both membrane-anchored and soluble forms, each mediating distinct biological act…
View article: Current and Future Treatments of Pancreatic Cancer
Current and Future Treatments of Pancreatic Cancer Open
Pancreatic cancer (PC) is among the most common tumors in the world. Its incidence rate increases with age. More than half of all pancreatic cancer deaths occur in developed regions. The overall prognosis of pancreatic cancer is pretty bad…
View article: Ad5-nCoV Vaccination Could Induce HLA-E Restricted CD8+ T Cell Responses Specific for Epitopes on Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein
Ad5-nCoV Vaccination Could Induce HLA-E Restricted CD8+ T Cell Responses Specific for Epitopes on Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Open
We evaluated cellular immune responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in an immunized population based on HLA-E-restricted CD8+ T cell epitope identification. HLA-E-restricted SARS-CoV-2 CD…
View article: ADAR1 protects pulmonary macrophages from sepsis-induced pyroptosis and lung injury through miR-21/A20 signaling
ADAR1 protects pulmonary macrophages from sepsis-induced pyroptosis and lung injury through miR-21/A20 signaling Open
Acute lung injury is a serious complication of sepsis with high morbidity and mortality. Pyroptosis is a proinflammatory form of programmed cell death that leads to immune dysregulation and organ dysfunction during sepsis. We previously fo…
View article: ADAR1 Inhibits Macrophage Apoptosis and Alleviates Sepsis-induced Liver Injury Through miR-122/BCL2A1 Signaling
ADAR1 Inhibits Macrophage Apoptosis and Alleviates Sepsis-induced Liver Injury Through miR-122/BCL2A1 Signaling Open
The findings show that ADAR1 alleviates macrophage apoptosis and sepsis-induced liver damage through the miR-122/BCL2A1 signaling pathway. The study provides novel insights into the development of therapeutic interventions in sepsis.
View article: Identification of hub genes and potential inhibitory compounds in the process of liver transplantation through transcriptome sequencing
Identification of hub genes and potential inhibitory compounds in the process of liver transplantation through transcriptome sequencing Open
Liver transplantation (LT) is the best choice for patients with end-stage liver diseases. In order to better understand pathophysiological alterations in LT, we aimed to identify potential hub genes and inhibitory compounds involved in the…
View article: CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions
CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions Open
Regulatory T (Treg) cells exhibit immunosuppressive phenotypes and particular metabolic patterns with certain degrees of plasticity. Previous studies of the effects of the co-stimulatory molecule CD226 on Treg cells are controversial. Here…
View article: Increased blood CD226 <sup>-</sup> inflammatory monocytes with low antigen presenting potential correlate positively with severity of hemorrhagic fever with renal syndrome
Increased blood CD226 <sup>-</sup> inflammatory monocytes with low antigen presenting potential correlate positively with severity of hemorrhagic fever with renal syndrome Open
CD226- iMOs increased during HTNV infection and the decrease in CD226 hampered the expression of HLA-DR/DP/DQ and CD80, which may promote the immune escape of HTNV and exacerbate clinical symptoms.
View article: <scp>CD226</scp> deficiency exacerbated intestinal immune dysregulation in mice with dinitrochlorobenzene‐induced atopic dermatitis
<span>CD226</span> deficiency exacerbated intestinal immune dysregulation in mice with dinitrochlorobenzene‐induced atopic dermatitis Open
Intestinal mucosal immunity plays a pivotal role in host defence. In this study, we found that cluster of differentiation 226 (CD226) gene knockout (KO) led to more severe atopic dermatitis (AD)‐related skin pathologies and bowel abnormali…
View article: Ad5-nCoV vaccination could induce HLA-E restricted CD8 + T cell responses specific for epitopes on severe acute respiratory syndrome coronavirus 2 spike protein
Ad5-nCoV vaccination could induce HLA-E restricted CD8 + T cell responses specific for epitopes on severe acute respiratory syndrome coronavirus 2 spike protein Open
Objectives: To evaluate cellular immune responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines immunization in population based on HLA-E-restricted CD8 T cell epitopes identification. Methods: HLA-E-rest…
View article: Alteration of gut microbiota after heat acclimation may reduce organ damage by regulating immune factors during heat stress
Alteration of gut microbiota after heat acclimation may reduce organ damage by regulating immune factors during heat stress Open
Introduction Heat-related illnesses can lead to morbidity, which are anticipated to increase frequency with predictions of increased global surface temperatures and extreme weather events. Although heat acclimation training (HAT) could pre…
View article: Identification of CaMK4 as a sex-difference-related gene in knee osteoarthritis
Identification of CaMK4 as a sex-difference-related gene in knee osteoarthritis Open
CaMK4 is a key sex-related gene influencing the progression and pathogenesis of OA and may be considered as a new target for OA treatment.
View article: Increased blood CD226<sup>-</sup> inflammatory monocytes with low antigen presenting potential correlate positively with severity of hemorrhagic fever with renal syndrome
Increased blood CD226<sup>-</sup> inflammatory monocytes with low antigen presenting potential correlate positively with severity of hemorrhagic fever with renal syndrome Open
Hantaan virus (HTNV) infection can cause severe hemorrhagic fever with renal syndrome (HFRS). Inflammatory monocytes (iMOs) are involved in early antiviral responses. Previous studies have found that blood iMOs numbers increase in the acut…
View article: IL-15 induced bystander activation of CD8+ T cells may mediate endothelium injury through NKG2D in Hantaan virus infection
IL-15 induced bystander activation of CD8+ T cells may mediate endothelium injury through NKG2D in Hantaan virus infection Open
Introduction Hantaan virus (HTNV) can cause endothelium injury in hemorrhagic fever with renal syndrome (HFRS) patients. Bystander activation of CD8+ T cells by virus infection has been shown that was involved in host injury, but it is unc…