R.A. Youness
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View article: Macrophage migration inhibitory factor (MIF) and the tumor ecosystem: a tale of inflammation, immune escape, and tumor growth
Macrophage migration inhibitory factor (MIF) and the tumor ecosystem: a tale of inflammation, immune escape, and tumor growth Open
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with a pivotal role in immune regulation, inflammation, and tumorigenesis. Originally identified as a T cell-derived factor inhibiting macrophage migration, MIF has sin…
View article: Unravelling novel microbial players in the breast tissue of TNBC patients: a meta-analytic perspective
Unravelling novel microbial players in the breast tissue of TNBC patients: a meta-analytic perspective Open
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC), accounting for nearly 40% of BC-related deaths. Emerging evidence suggests that the breast tissue microbiome harbors distinct microbial communities;…
View article: Editorial: Advancements in multi-omics and bioinformatics for the management of solid malignancies
Editorial: Advancements in multi-omics and bioinformatics for the management of solid malignancies Open
View article: A comprehensive review on targeted therapies for triple negative breast cancer: an evidence-based treatment guideline
A comprehensive review on targeted therapies for triple negative breast cancer: an evidence-based treatment guideline Open
View article: Deciphering the mysteries of MEG3 LncRNA and its implications in genitourinary cancers
Deciphering the mysteries of MEG3 LncRNA and its implications in genitourinary cancers Open
Maternally expressed gene 3 (MEG3), a long non-coding RNA, plays a pivotal role in various biological processes, including tumorigenesis. Aberrant expression of MEG3 has been implicated in several cancers, including genitourinary malignanc…
View article: In-vitro immune-modulation of triple-negative breast cancer through targeting miR-30a-5p/MALAT1 axis using nano-PDT combinational approach
In-vitro immune-modulation of triple-negative breast cancer through targeting miR-30a-5p/MALAT1 axis using nano-PDT combinational approach Open
This study demonstrated that CLNPs and Ce-6-mediated PDT can modulate several key immunosuppressive factors and the miR-30a-5p/MALAT1 axis in TNBC cells. These findings provide a rationale for further in-vivo investigation of this multimod…
View article: 44P Potential combination of anti-CD-47 and natural compounds to harness calreticulin/CD47 immune checkpoint in triple-negative breast cancer patients
44P Potential combination of anti-CD-47 and natural compounds to harness calreticulin/CD47 immune checkpoint in triple-negative breast cancer patients Open
View article: MIAT: A pivotal oncogenic long noncoding RNA tunning the hallmarks of solid malignancies
MIAT: A pivotal oncogenic long noncoding RNA tunning the hallmarks of solid malignancies Open
View article: Extracellular vesicles: from intracellular trafficking molecules to fully fortified delivery vehicles for cancer therapeutics
Extracellular vesicles: from intracellular trafficking molecules to fully fortified delivery vehicles for cancer therapeutics Open
Extracellular vesicles (EVs) are emerging tools in cancer diagnosis, prognosis and therapeutics.
View article: MIAT, HEIH, and HOTAIR: A novel LncRNA signature in non-metastatic hepatocellular carcinoma patients
MIAT, HEIH, and HOTAIR: A novel LncRNA signature in non-metastatic hepatocellular carcinoma patients Open
View article: 26P Liquid biopsy-based percision immunotherapy: CCAT1 and HEIH lncRNAs identify young breast cancer patients likely to respond to PD-L1 blockade
26P Liquid biopsy-based percision immunotherapy: CCAT1 and HEIH lncRNAs identify young breast cancer patients likely to respond to PD-L1 blockade Open
View article: miR-17–5p/STAT3/H19: A novel regulatory axis tuning ULBP2 expression in young breast cancer patients
miR-17–5p/STAT3/H19: A novel regulatory axis tuning ULBP2 expression in young breast cancer patients Open
View article: OncomiR-181a promotes carcinogenesis by repressing the extracellular matrix proteoglycan decorin in hepatocellular carcinoma
OncomiR-181a promotes carcinogenesis by repressing the extracellular matrix proteoglycan decorin in hepatocellular carcinoma Open
To our knowledge, this is the first study to unveil the direct targeting of DCN by oncomiR-181a. We also highlighted that miR-181a affects targets related to cellular proliferation in HCC which may be partly mediated through inhibition of …
View article: A Comprehensive Insight and In Silico Analysis of CircRNAs in Hepatocellular Carcinoma: A Step toward ncRNA-Based Precision Medicine
A Comprehensive Insight and In Silico Analysis of CircRNAs in Hepatocellular Carcinoma: A Step toward ncRNA-Based Precision Medicine Open
Circular RNAs (circRNAs) are cardinal players in numerous physiological and pathological processes. CircRNAs play dual roles as tumor suppressors and oncogenes in different oncological contexts, including hepatocellular carcinoma (HCC). Th…
View article: A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma
A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma Open
View article: Pan-inhibition of the three H2S synthesizing enzymes restrains tumor progression and immunosuppression in breast cancer
Pan-inhibition of the three H2S synthesizing enzymes restrains tumor progression and immunosuppression in breast cancer Open
Background Hydrogen sulfide (H 2 S) is a significant endogenous mediator that has been implicated in the progression of various forms of cancer including breast cancer (BC). Cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE), and …
View article: Involvement of CircRNAs in regulating The “New Generation of Cancer Hallmarks”: A Special Depiction on Hepatocellular Carcinoma
Involvement of CircRNAs in regulating The “New Generation of Cancer Hallmarks”: A Special Depiction on Hepatocellular Carcinoma Open
The concept of 'Hallmarks of Cancer' is an approach of reducing the enormous complexity of cancer to a set of guiding principles. As the underlying mechanism of cancer are portrayed, we find that we gain insight and additional aspects of t…
View article: Hijacking 5-Fluorouracil Chemoresistance in Triple Negative Breast Cancer via microRNAs-Loaded Chitosan Nanoparticles
Hijacking 5-Fluorouracil Chemoresistance in Triple Negative Breast Cancer via microRNAs-Loaded Chitosan Nanoparticles Open
Chemotherapy is still the mainstay of treatment for triple-negative breast cancer (TNBC) patients. Yet only 20% of TNBC patients show a pathologic complete response (pCR) after neoadjuvant chemotherapy. 5-Fluorouracil (5-FU) is a stable co…
View article: 107P Inhibition of hydrogen sulfide biosynthesis influences mitochondrial biogenesis in breast cancer
107P Inhibition of hydrogen sulfide biosynthesis influences mitochondrial biogenesis in breast cancer Open
In humans, cystathionine-β-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST) biosynthesize Hydrogen Sulphide (H2S). The expression of these enzymes was found to be significantly upregulated i…
View article: 42P sONE and MEG3: Novel immunomodulatory tumor suppressor LncRNAs in HCV-induced hepatocellular carcinoma patients
42P sONE and MEG3: Novel immunomodulatory tumor suppressor LncRNAs in HCV-induced hepatocellular carcinoma patients Open
Hepatocellular carcinoma (HCC) is one of the most fatal solid malignancies. Recently, the emergence of immune checkpoint inhibitor (ICI) has revolutionized HCC therapeutic regimens. Galectins (Gal-) 1,3,9 have been casted as recent immune …
View article: MIAT LncRNA: A multifunctional key player in non-oncological pathological conditions
MIAT LncRNA: A multifunctional key player in non-oncological pathological conditions Open
The discovery of non-coding RNAs (ncRNAs) has unveiled a wide range of transcripts that do not encode proteins but play key roles in several cellular and molecular processes. Long noncoding RNAs (lncRNAs) are specific class of ncRNAs that …
View article: Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review
Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review Open
Recently, myriad studies have defined the versatile abilities of gasotransmitters and their synthesizing enzymes to play a “Maestro” role in orchestrating several oncological and non-oncological circuits and, thus, nominated them as possib…
View article: Puzzling out the role of MIAT LncRNA in hepatocellular carcinoma
Puzzling out the role of MIAT LncRNA in hepatocellular carcinoma Open
View article: Revolutionizing cancer therapy: nanoformulation of miRNA-34 – enhancing delivery and efficacy for various cancer immunotherapies: a review
Revolutionizing cancer therapy: nanoformulation of miRNA-34 – enhancing delivery and efficacy for various cancer immunotherapies: a review Open
Despite recent advancements in cancer therapies, challenges such as severe toxic effects, non-selective targeting, resistance to chemotherapy and radiotherapy, and recurrence of metastatic tumors persist.
View article: Emerging tendencies for the nano-delivery of gambogic acid: a promising approach in oncotherapy
Emerging tendencies for the nano-delivery of gambogic acid: a promising approach in oncotherapy Open
Despite the advancements in cancer therapies during the past few years, chemo/photo resistance, severe toxic effects, recurrence of metastatic tumors, and non-selective targeting remain incomprehensible.
View article: Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology
Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology Open
The host immune system status remains an unresolved mystery among several malignancies. An immune-compromised state or smart immune-surveillance tactics orchestrated by cancer cells are the primary cause of cancer invasion and metastasis. …
View article: 175P MicroRNA-548c: An immune-activator microRNA at the tumor microenvironment and immune milieu of breast cancer
175P MicroRNA-548c: An immune-activator microRNA at the tumor microenvironment and immune milieu of breast cancer Open
Cancer cells evade the human immune system by manipulating the tumor-immune microenvironment (TIME) via suppressing the immuno-activator and promoting the immune-suppressive mediators. Hence, targeting immuno-modulatory factors became an i…
View article: Emerging Role of Circular RNAs in Hepatocellular Carcinoma Immunotherapy
Emerging Role of Circular RNAs in Hepatocellular Carcinoma Immunotherapy Open
Hepatocellular carcinoma (HCC) is a highly fatal malignancy with limited therapeutic options and high recurrence rates. Recently, immunotherapeutic agents such as immune checkpoint inhibitors (ICIs) have emerged as a new paradigm shift in …
View article: A Snapshot of Photoresponsive Liposomes in Cancer Chemotherapy and Immunotherapy: Opportunities and Challenges
A Snapshot of Photoresponsive Liposomes in Cancer Chemotherapy and Immunotherapy: Opportunities and Challenges Open
To provide precise medical regimens, photonics technologies have been involved in the field of nanomedicine. Phototriggered liposomes have been cast as promising nanosystems that achieve controlled release of payloads in several pathologic…
View article: Dual targeting of H2S synthesizing enzymes; cystathionine β-synthase and cystathionine γ-lyase by miR-939-5p effectively curbs triple negative breast cancer
Dual targeting of H2S synthesizing enzymes; cystathionine β-synthase and cystathionine γ-lyase by miR-939-5p effectively curbs triple negative breast cancer Open
This study sheds light on the reciprocal relationship between CBS and CSE and on the importance of their dual targeting, particularly in TNBC. It also postulates miR-939-5p as a potent dual repressor for CBS and CSE overcoming their redund…