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View article: Senescence controls prostatic neoplasia driven by Pten loss
Senescence controls prostatic neoplasia driven by Pten loss Open
We report that Pten (phosphatase and tensin homologue) ablation in prostatic epithelial cells of adult mice promotes cell proliferation to generate prostatic intraepithelial neoplasia. Moreover, our results demonstrate that proliferating P…
View article: Characterization of Pten and Trp53 deficient prostatic tumors in mice
Characterization of Pten and Trp53 deficient prostatic tumors in mice Open
Prostate cancer (PCa) is a leading cause of male cancer death worldwide. While most locally PCa are curable, metastatic tumors initially respond to androgen deprivation therapy but ultimately relapse to castration-resistant prostate cancer…
View article: <i>PTEN</i> deletion in luminal cells of mature prostate induces replication stress and senescence in vivo
<i>PTEN</i> deletion in luminal cells of mature prostate induces replication stress and senescence in vivo Open
Genetic ablation of the tumor suppressor PTEN in prostatic epithelial cells (PECs) induces cell senescence. However, unlike oncogene-induced senescence, no hyperproliferation phase and no signs of DNA damage response (DDR) were observed in…