Randall H. Goldsmith
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View article: Single-Particle Photothermal Microscopy Using On-Chip Silicon Nitride Microring Resonators
Single-Particle Photothermal Microscopy Using On-Chip Silicon Nitride Microring Resonators Open
Optical microresonators confine light in time and space, enabling high sensitivity for the detection of small thermal perturbations. We utilized these properties and investigated on-chip integrated silicon nitride microring resonators (MRR…
View article: Molecule by Molecule Characterization of a Polymer Molecular Mass Distribution via Mass Photometry
Molecule by Molecule Characterization of a Polymer Molecular Mass Distribution via Mass Photometry Open
Polymer analysis tools form the backbone of modern polymer technology. However, traditional tools like size exclusion chromatography (SEC) coupled with online detectors fractionate based on hydrodynamic volume. This analysis assumes that a…
View article: Imaging of Lithium Ion Release from Individual Cathode Particles Shows Evidence for Diversity of Intraparticle Contacts
Imaging of Lithium Ion Release from Individual Cathode Particles Shows Evidence for Diversity of Intraparticle Contacts Open
The ability to observe nanoscale transport of lithium ions in battery functional components with high spatial and temporal resolution can offer a powerful source of mechanistic insight. While existing methods can provide dynamics for singl…
View article: Evidence of a Three-State Mechanism in DNA Hairpin Folding
Evidence of a Three-State Mechanism in DNA Hairpin Folding Open
DNA hairpins are a model system for biomolecule folding as well as key structures in biology and nanotechnology. However, limitations in traditional solution-phase spectroscopy shorten the window of observable kinetics and cannot account f…
View article: Circularly Polarized Stimulated Emission from a Chiral Cavity Based on Apparent Circular Dichroism Organic Thin Films
Circularly Polarized Stimulated Emission from a Chiral Cavity Based on Apparent Circular Dichroism Organic Thin Films Open
The lack of intrinsic mirror symmetry in cavity mirrors poses a significant challenge for most organic chiral materials in generating circularly polarized (CP) lasers. However, nonreciprocal chiroptical materials, such as recently develope…
View article: Circularly Polarized Stimulated Emission from a Chiral Cavity Based on Apparent Circular Dichroism Organic Thin-Films
Circularly Polarized Stimulated Emission from a Chiral Cavity Based on Apparent Circular Dichroism Organic Thin-Films Open
The lack of intrinsic mirror symmetry in cavity mirrors poses a significant challenge for most organic chiral materials in generating circularly polarized (CP) lasers. How ever, nonreciprocal chiroptical materials, such as the recently dev…
View article: Evidence of a Three-State Mechanism in DNA Hairpins Folding
Evidence of a Three-State Mechanism in DNA Hairpins Folding Open
DNA hairpins are a model system for biomolecule folding as well as key structures in biology and nanotechnology. However, limitations in traditional solution-phase spectroscopy shorten the window of observable kinetics and cannot account f…
View article: Lipid bilayers determine allostery but not intrinsic affinity of cAMP binding to pacemaker channels
Lipid bilayers determine allostery but not intrinsic affinity of cAMP binding to pacemaker channels Open
Cyclic adenosine monophosphate (cAMP), a second messenger, binds to hyperpolarization and cyclic nucleotide-gated (HCN) ion channels and regulates the automaticity of pacemaking activity. While cellular studies suggest that cAMP binding to…
View article: Backscatter absorption spectroscopy for process monitoring in powder bed fusion
Backscatter absorption spectroscopy for process monitoring in powder bed fusion Open
Laser powder bed fusion is a metal 3D printing technology that involves melting and solidifying a metal powder using a process laser or electron beam. The interaction of metal vapors with the melt pool is known to cause manufacturing defec…
View article: Differential Absorption of Circularly Polarized Light by a Centrosymmetric Inorganic Crystal
Differential Absorption of Circularly Polarized Light by a Centrosymmetric Inorganic Crystal Open
Properties of crystalline inorganic materials are governed by universal structure–property relationships derived from their crystal symmetry, leading to paradigmatic rules on what they can and cannot do. A long-held structure–property rela…
View article: Spectroscopy in Nanoscopic Cavities: Models and Recent Experiments
Spectroscopy in Nanoscopic Cavities: Models and Recent Experiments Open
The ability of nanophotonic cavities to confine and store light to nanoscale dimensions has important implications for enhancing molecular, excitonic, phononic, and plasmonic optical responses. Spectroscopic signatures of processes that ar…
View article: Quantifying Microsecond Solution-Phase Conformational Dynamics of a DNA Hairpin at the Single-Molecule Level
Quantifying Microsecond Solution-Phase Conformational Dynamics of a DNA Hairpin at the Single-Molecule Level Open
Quantifying the rapid conformational dynamics of biological systems is fundamental to understanding the mechanism. However, biomolecules are complex, often containing static and dynamic heterogeneity, thus motivating the use of single-mole…
View article: High-power Raman lasing and efficient anti-Stokes generation in mm-sized glass disk resonators
High-power Raman lasing and efficient anti-Stokes generation in mm-sized glass disk resonators Open
We have previously experimentally observed high power Stokes and second-order Stokes output from a mm-sized CaF2 disk using stimulated Raman scattering. A pump laser at a wavelength of 1.06 μm was coupled via a tapered fiber to the whisper…
View article: High-power Raman lasing and efficient anti-Stokes generation in mm-sized glass disk resonators
High-power Raman lasing and efficient anti-Stokes generation in mm-sized glass disk resonators Open
We have previously experimentally observed high power Stokes and second-order Stokes output from a mm-sized CaF2 disk using stimulated Raman scattering. A pump laser at a wavelength of 1.06 μm was coupled via a tapered fiber to the whisper…
View article: Backscatter absorption spectroscopy for process monitoring in powder bed fusion
Backscatter absorption spectroscopy for process monitoring in powder bed fusion Open
Laser powder bed fusion is a metal 3D printing technology that involves melting and solidifying a metal powder using a process laser or electron beam. The interaction of metal vapors with the melt pool is known to cause manufacturing defec…
View article: The Role of Experimental Noise in a Hybrid Classical-Molecular Computer to Solve Combinatorial Optimization Problems
The Role of Experimental Noise in a Hybrid Classical-Molecular Computer to Solve Combinatorial Optimization Problems Open
Chemical and molecular-based computers may be promising alternatives to modern silicon-based computers. In particular, hybrid systems, where tasks are split between a chemical medium and traditional silicon components, may provide access a…
View article: A Chiral Microcavity based on Apparent Circular Dichroism
A Chiral Microcavity based on Apparent Circular Dichroism Open
Breaking the symmetry between left-handed and right-handed chiral optical modes in planar Fabry–Pérot (FP) microcavities would enable a variety of chiral light-matter phenomena, with applications in spintronics, polaritonics, and chiral la…
View article: Strategies for Overcoming the Single-Molecule Concentration Barrier
Strategies for Overcoming the Single-Molecule Concentration Barrier Open
Fluorescence-based single-molecule approaches have helped revolutionize our understanding of chemical and biological mechanisms. Unfortunately, these methods are only suitable at low concentrations of fluorescent molecules so that single f…
View article: Label-free observation of individual solution phase molecules
Label-free observation of individual solution phase molecules Open
The vast majority of chemistry and biology occurs in solution, and new label-free analytical techniques that can help resolve solution-phase complexity at the single-molecule level can provide new microscopic perspectives of unprecedented …
View article: Thermodynamic coupling of reactions via few-molecule vibrational polaritons
Thermodynamic coupling of reactions via few-molecule vibrational polaritons Open
Interaction between light and molecular vibrations leads to hybrid light-matter states called vibrational polaritons. Even though many intriguing phenomena have been predicted for single-molecule vibrational strong coupling (VSC), several …
View article: A path towards single molecule vibrational strong coupling in a Fabry–Pérot microcavity
A path towards single molecule vibrational strong coupling in a Fabry–Pérot microcavity Open
Few-molecule vibrational strong coupling in a microcavity using cavity optomechanics and its application as cavity-mediated thermodynamic coupling of chemical reactions.
View article: Active Control of Plasmonic–Photonic Interactions in a Microbubble Cavity
Active Control of Plasmonic–Photonic Interactions in a Microbubble Cavity Open
Active control of light-matter interactions using nanophotonic structures is critical for new modalities for solar energy production, cavity quantum electrodynamics (QED), and sensing, particularly at the single-particle level, where it un…
View article: Chiral polaritons based on achiral Fabry-Perot cavities using apparent circular dichroism
Chiral polaritons based on achiral Fabry-Perot cavities using apparent circular dichroism Open
Polariton states with high levels of chiral dissymmetry offer exciting prospects for quantum information, sensing, and lasing applications. Such dissymmetry must emanate from either the involved optical resonators or the quantum emitters. …
View article: Compounding a High-Permittivity Thermoplastic Material and Its Applicability in Manufacturing of Microwave Photonic Crystals
Compounding a High-Permittivity Thermoplastic Material and Its Applicability in Manufacturing of Microwave Photonic Crystals Open
Additive Manufacturing (AM) techniques allow the production of complex geometries unattainable through other traditional technologies. This advantage lends itself well to rapidly iterating and improving upon the design of microwave photoni…
View article: Strong and long-range radiative interaction between resonant transitions
Strong and long-range radiative interaction between resonant transitions Open
Enhancing the radiative interaction between quantum electronic transitions is of general interest. There are two important properties of radiative interaction: the range and the strength. There has been a trade-off between the range and th…