Randall K. Mann
YOU?
Author Swipe
View article: Del1 Is a Growth Factor for Skeletal Progenitor Cells in the Fracture Callus
Del1 Is a Growth Factor for Skeletal Progenitor Cells in the Fracture Callus Open
Failure to properly form bone or integrate surgical implants can lead to morbidity and additional surgical interventions in a significant proportion of orthopedic surgeries. While the role of skeletal stem cells (SSCs) in bone formation an…
View article: Neuronal delivery of Hedgehog directs spatial patterning of taste organ regeneration
Neuronal delivery of Hedgehog directs spatial patterning of taste organ regeneration Open
Significance The maintenance of taste sensory organs (taste buds) in the tongue has been known for 140 years to depend on sensory innervation from distant neurons by an unknown mechanism. We find that maintenance and regeneration of taste …
View article: Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols
Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols Open
Significance The Hedgehog protein signal (Hh), covalently modified by cholesterol, functions to coordinate embryonic tissue patterning and postembryonic tissue maintenance. Cholesterol and several of its side-chain oxidized derivatives als…
View article: Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5
Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5 Open
Binding of the Hedgehog (Hh) protein signal to its receptor, Patched, induces accumulation of the seven-pass transmembrane protein Smoothened (Smo) within the primary cilium and of the zinc finger transcription factor Gli2 at the ciliary t…