Randy Foo
YOU?
Author Swipe
View article: Heat stress response in the cave nectar bat Eonycteris spelaea differs from that of Mus musculus
Heat stress response in the cave nectar bat Eonycteris spelaea differs from that of Mus musculus Open
Bats as the only flying mammals incur a high metabolic cost during extended powered flight, which results in febrile-like temperatures without injury. Herein, we investigate the in vivo heat shock response (HSR) in the cave nectar bat Eony…
View article: Cardiac Adaptations in the Cave Nectar Bat <i>Eonycteris spelaea</i> : Insights into Metabolic Resilience and Stress Response
Cardiac Adaptations in the Cave Nectar Bat <i>Eonycteris spelaea</i> : Insights into Metabolic Resilience and Stress Response Open
Aims Bats are unique mammals with remarkable adaptations, including powered flight, which demands significant energy expenditure. While previous studies have documented basic structural characteristics of bat hearts, a comprehensive unders…
View article: P-364. Outbreak of <i>bla-</i>OXA-48 in the eastern part of Singapore
P-364. Outbreak of <i>bla-</i>OXA-48 in the eastern part of Singapore Open
Background Changi General hospital (CGH) is a 1000 bed acute hospital that mainly serves the general population in the eastern region of Singapore and community. At the beginning of October 2023 till March 2024, we observed an increase in …
View article: Application of a bespoke monoclonal antibody panel to characterize immune cell populations in cave nectar bats
Application of a bespoke monoclonal antibody panel to characterize immune cell populations in cave nectar bats Open
Among their many unique biological features, bats are increasingly recognized as a key reservoir of many emerging viruses that cause massive morbidity and mortality in humans. Bats are capable of harboring many of these deadly viruses with…
View article: Applications of VirScan to broad serological profiling of bat reservoirs for emerging zoonoses
Applications of VirScan to broad serological profiling of bat reservoirs for emerging zoonoses Open
Introduction Bats are important providers of ecosystem services such as pollination, seed dispersal, and insect control but also act as natural reservoirs for virulent zoonotic viruses. Bats host multiple viruses that cause life-threatenin…
View article: Mast cell activation in lungs during SARS-CoV-2 infection associated with lung pathology and severe COVID-19
Mast cell activation in lungs during SARS-CoV-2 infection associated with lung pathology and severe COVID-19 Open
Lung inflammation is a hallmark of Coronavirus disease 2019 (COVID-19) in patients who are severely ill, and the pathophysiology of disease is thought to be immune mediated. Mast cells (MCs) are polyfunctional immune cells present in the a…
View article: Genomic Characterization of a Relative of Mumps Virus in Lesser Dawn Bats of Southeast Asia
Genomic Characterization of a Relative of Mumps Virus in Lesser Dawn Bats of Southeast Asia Open
The importance of genomic surveillance on emerging diseases continues to be highlighted with the ongoing SARS-CoV-2 pandemic. Here, we present an analysis of a new bat-borne mumps virus (MuV) in a captive colony of lesser dawn bats (Eonyct…
View article: Generation of self-replicating airway organoids from the cave nectar bat <i>Eonycteris spelaea</i> as a model system for studying host–pathogen interactions in the bat airway epithelium
Generation of self-replicating airway organoids from the cave nectar bat <i>Eonycteris spelaea</i> as a model system for studying host–pathogen interactions in the bat airway epithelium Open
Bats are reservoir hosts for various zoonotic viruses with pandemdic potential in humans and livestock. In vitro systems for studying bat host-pathogen interactions are of significant interest. Here, we establish protocols to generate bat …
View article: Establishment of a Captive Cave Nectar Bat (<i>Eonycteris spelaea</i>) Breeding Colony in Singapore
Establishment of a Captive Cave Nectar Bat (<i>Eonycteris spelaea</i>) Breeding Colony in Singapore Open
Bats are known natural reservoirs of several highly pathogenic zoonotic viruses, including Hendra virus, Nipah virus, rabies virus, SARS-like coronaviruses, and suspected ancestral reservoirs of SARS-CoV-2 responsible for the ongoing COVID…
View article: Generation of self-replicating airway organoids from the cave nectar bat <i>Eonycteris spelaea</i> as a model system for studying host–pathogen interactions in the bat airway epithelium
Generation of self-replicating airway organoids from the cave nectar bat <i>Eonycteris spelaea</i> as a model system for studying host–pathogen interactions in the bat airway epithelium Open
Bats are reservoir hosts for various zoonotic viruses with pandemdic potential in humans and livestock. In vitro systems for studying bat host–pathogen interactions are of significant interest. Here, we establish protocols to generate bat …
View article: Signatures of mast cell activation are associated with severe COVID-19
Signatures of mast cell activation are associated with severe COVID-19 Open
Lung inflammation is a hallmark of Coronavirus disease 2019 (COVID-19) in severely ill patients and the pathophysiology of disease is thought to be immune-mediated. Mast cells (MCs) are polyfunctional immune cells present in the airways, w…
View article: A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19
A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19 Open
An accurate depiction of the convalescent COVID-19 immunome will help delineate the immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized the immune architecture in patients recovering f…
View article: Culture, expansion, and flow-cytometry-based functional analysis of pteropid bat MR1-restricted unconventional T cells
Culture, expansion, and flow-cytometry-based functional analysis of pteropid bat MR1-restricted unconventional T cells Open
Bats harbor viruses of global public health significance. Understanding bat immune systems may provide intervention strategies to prevent zoonotic disease transmission and identify therapeutic targets. This protocol describes how to cultur…
View article: Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity
Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity Open
Background Key knowledge gaps remain in the understanding of viral dynamics and immune response of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Methods We evaluated these characteristics and established their ass…
View article: Novel Insights for Biosurveillance of Bat-Borne Viruses
Novel Insights for Biosurveillance of Bat-Borne Viruses Open
Bats are rich reservoirs of viruses, including several high consequence zoonoses. In this study, high throughput sequencing was used to characterize the virome through a longitudinal study of a captive colony of lesser dawn bats, species E…
View article: Detection of Recombinant Rousettus Bat Coronavirus GCCDC1 in Lesser Dawn Bats (Eonycteris spelaea) in Singapore
Detection of Recombinant Rousettus Bat Coronavirus GCCDC1 in Lesser Dawn Bats (Eonycteris spelaea) in Singapore Open
Rousettus bat coronavirus GCCDC1 (RoBat-CoV GCCDC1) is a cross-family recombinant coronavirus that has previously only been reported in wild-caught bats in Yúnnan, China. We report the persistence of a related strain in a captive colony of…
View article: Immunophenotyping monocytes, macrophages and granulocytes in the Pteropodid bat Eonycteris spelaea
Immunophenotyping monocytes, macrophages and granulocytes in the Pteropodid bat Eonycteris spelaea Open
Bats are asymptomatic reservoir hosts for several highly pathogenic viruses. Understanding this enigmatic relationship between bats and emerging zoonotic viruses requires tools and approaches which enable the comparative study of bat immun…
View article: The temporal RNA virome patterns of a lesser dawn bat (Eonycteris spelaea) colony revealed by deep sequencing
The temporal RNA virome patterns of a lesser dawn bat (Eonycteris spelaea) colony revealed by deep sequencing Open
The virosphere is largely unexplored and the majority of viruses are yet to be represented in public sequence databases. Bats are rich reservoirs of viruses, including several zoonoses. In this study, high throughput sequencing (HTS) of vi…
View article: Serological differentiation between COVID-19 and SARS infections
Serological differentiation between COVID-19 and SARS infections Open
In response to the coronavirus disease 2019 (COVID-19) outbreak, caused by SARS-CoV-2, multiple diagnostic tests are required for acute disease diagnosis, contact tracing, monitoring asymptomatic infection rates and assessing herd immunity…
View article: Bat-mouse bone marrow chimera: a novel animal model for dissecting the uniqueness of the bat immune system
Bat-mouse bone marrow chimera: a novel animal model for dissecting the uniqueness of the bat immune system Open
Bats are an important animal model with long lifespans, low incidences of tumorigenesis and an ability to asymptomatically harbour pathogens. Currently, in vivo studies of bats are hampered due to their low reproduction rates. To overcome …