Randy Hurley
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View article: Clinical Profile and Outcome of Pancreatic Head Malignancies Among Patients at a Tertiary Referral Hospital – A Seven-year Retrospective Review
Clinical Profile and Outcome of Pancreatic Head Malignancies Among Patients at a Tertiary Referral Hospital – A Seven-year Retrospective Review Open
Background: Malignancies of the head of the pancreas pose a significant global challenge due to their late presentation and the disease's aggressive nature. Modifiable risk factors, such as obesity, cigarette smoking, and alcohol consumpti…
View article: 611 XTX202–01/02–001, Phase 1/2 first-in human study of XTX202, a masked, tumor-activated IL-2βγ, in patients with advanced solid tumors: results from phase 1
611 XTX202–01/02–001, Phase 1/2 first-in human study of XTX202, a masked, tumor-activated IL-2βγ, in patients with advanced solid tumors: results from phase 1 Open
Background Aldesleukin requires high systemic doses (8.4 million IU/kg equaling 0.518 mg/kg per weekly cycle) to achieve therapeutic benefit; however, such doses typically result in life-threatening toxicities. 'Non-α' interleukin-2 (IL-2)…