Randy S. Haun
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View article: High-Fidelity CRISPR-Cas12a–Based Apolipoprotein L1 Genotyping
High-Fidelity CRISPR-Cas12a–Based Apolipoprotein L1 Genotyping Open
Key Points A protospacer adjacent motif sequence is not required for CRISPR-Cas12a–mediated cis-cleavage of apolipoprotein L1 risk allele sequences. Discrimination of both single-nucleotide and insertion/deletion variants can be accurately…
View article: APOL1 Risk Variants and Acute Kidney Injury in Black Americans with COVID-19
APOL1 Risk Variants and Acute Kidney Injury in Black Americans with COVID-19 Open
Background and objectives Black Americans have a higher incidence of kidney disease compared with populations that do not have recent African ancestry. Two risk variants in the APOL1 are responsible for a portion of this higher risk. We so…