Randy W. Lesh
YOU?
Author Swipe
View article: Optimizing and Validating Systemic DNA Damage Response Profiling to Predict Neoadjuvant Chemoradiation Response in Rectal Cancer
Optimizing and Validating Systemic DNA Damage Response Profiling to Predict Neoadjuvant Chemoradiation Response in Rectal Cancer Open
Purpose This study aimed to stratify patients with locally advanced rectal cancer (LARC) based on their response to neoadjuvant chemoradiation therapy (nCRT) using DNA damage response (DDR)-related proteins measured in peripheral blood mon…
View article: Predictors of and outcomes related to perioperative myocardial injury post‐tracheotomy
Predictors of and outcomes related to perioperative myocardial injury post‐tracheotomy Open
Introduction Perioperative myocardial injury (PMI) is associated with increased mortality. We describe risk factors for and outcomes of PMI in patients undergoing tracheotomy. Methods Retrospective study of patients undergoing tracheotomy …
View article: Thyroid Abscess: A Case Series and Literature Review
Thyroid Abscess: A Case Series and Literature Review Open
Objective In this retrospective case series, we chronicle six patients presenting with acute suppurative thyroiditis (AST) with progression to thyroid abscess in a single institution. Methods Patients ranged in age from 16 to 74 years of a…
View article: Prevalence of pathogenic variants in DNA damage response genes in patients undergoing cancer risk assessment and reporting a personal history of early-onset renal cancer
Prevalence of pathogenic variants in DNA damage response genes in patients undergoing cancer risk assessment and reporting a personal history of early-onset renal cancer Open
Purpose Pathogenic variants (PVs) in a number of genes are known to increase the risk of hereditary renal cancer (hRC). However, many early-onset RC (eoRC) patients undergoing genetic testing lack PVs in hRC genes; thus, their genetic risk…
View article: Functional analysis of rare variants in mismatch repair proteins augments results from computation-based predictive methods
Functional analysis of rare variants in mismatch repair proteins augments results from computation-based predictive methods Open
The cancer-predisposing Lynch Syndrome (LS) arises from germline mutations in DNA mismatch repair (MMR) genes, predominantly MLH1, MSH2, MSH6, and PMS2. A major challenge for clinical diagnosis of LS is the frequent identification of varia…