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View article: Emerging PET Imaging Agents and Targeted Radioligand Therapy: A Review of Clinical Applications and Trials
Emerging PET Imaging Agents and Targeted Radioligand Therapy: A Review of Clinical Applications and Trials Open
Targeted radioligand therapy (RLT) is an emerging field in anticancer therapeutics with great potential across tumor types and stages of disease. While much progress has focused on agents targeting somatostatin receptors and prostate-speci…
View article: Mixed histiocytic neoplasms: A multicentre series revealing diverse somatic mutations and responses to targeted therapy
Mixed histiocytic neoplasms: A multicentre series revealing diverse somatic mutations and responses to targeted therapy Open
Summary Histiocytic neoplasms are diverse clonal haematopoietic disorders, and clinical disease is mediated by tumorous infiltration as well as uncontrolled systemic inflammation. Individual subtypes include Langerhans cell histiocytosis (…
View article: First-in-Human Evaluation of Site-Specifically Labeled<sup>89</sup>Zr-Pertuzumab in Patients with HER2-Positive Breast Cancer
First-in-Human Evaluation of Site-Specifically Labeled<sup>89</sup>Zr-Pertuzumab in Patients with HER2-Positive Breast Cancer Open
Radioimmunoconjugates targeting human epidermal growth factor receptor 2 (HER2) have shown potential to noninvasively visualize HER2-positive tumors. However, the stochastic approach that has been traditionally used to radiolabel these ant…
View article: Advances in CAR T Cell Therapy for Non-Small Cell Lung Cancer
Advances in CAR T Cell Therapy for Non-Small Cell Lung Cancer Open
Since its first approval by the FDA in 2017, tremendous progress has been made in chimeric antigen receptor (CAR) T cell therapy, the adoptive transfer of engineered, CAR-expressing T lymphocyte. CAR T cells are all composed of three main …
View article: Artificial Intelligence and Radiomics: Clinical Applications for Patients with Advanced Melanoma Treated with Immunotherapy
Artificial Intelligence and Radiomics: Clinical Applications for Patients with Advanced Melanoma Treated with Immunotherapy Open
Immunotherapy has greatly improved the outcomes of patients with metastatic melanoma. However, it has also led to new patterns of response and progression, creating an unmet need for better biomarkers to identify patients likely to achieve…
View article: PET/CT and SPECT/CT Imaging of HER2-Positive Breast Cancer
PET/CT and SPECT/CT Imaging of HER2-Positive Breast Cancer Open
HER2 (Human Epidermal Growth Factor Receptor 2)-positive breast cancer is characterized by amplification of the HER2 gene and is associated with more aggressive tumor growth, increased risk of metastasis, and poorer prognosis when compared…
View article: Advances in PET/CT Imaging for Breast Cancer
Advances in PET/CT Imaging for Breast Cancer Open
One out of eight women will be affected by breast cancer during her lifetime. Imaging plays a key role in breast cancer detection and management, providing physicians with information about tumor location, heterogeneity, and dissemination.…
View article: Novel Targets, Novel Treatments: The Changing Landscape of Non-Small Cell Lung Cancer
Novel Targets, Novel Treatments: The Changing Landscape of Non-Small Cell Lung Cancer Open
Treatment of non-small cell lung cancer (NSCLC) has undergone a paradigm shift. Once a disease with limited potential therapies, treatment options for patients have exploded with the availability of molecular testing to direct management a…
View article: More than Just Skin-Deep: A Review of Imaging’s Role in Guiding CAR T-Cell Therapy for Advanced Melanoma
More than Just Skin-Deep: A Review of Imaging’s Role in Guiding CAR T-Cell Therapy for Advanced Melanoma Open
Advanced melanoma is one of the deadliest cancers, owing to its invasiveness and its propensity to develop resistance to therapy. Surgery remains the first-line treatment for early-stage tumors but is often not an option for advanced-stage…
View article: Durvalumab and PET-Directed Chemoradiation in Locally Advanced Esophageal Adenocarcinoma
Durvalumab and PET-Directed Chemoradiation in Locally Advanced Esophageal Adenocarcinoma Open
Objective: To determine the safety and efficacy of adding the anti-PD-L1 antibody durvalumab to induction FOLFOX and preoperative chemotherapy in locally advanced esophageal adenocarcinoma. Background: Neoadjuvant induction FOLFOX followed…
View article: Machine Learning-derived Clinical Decision Algorithm for the Diagnosis of Hyperfunctioning Parathyroid Glands in Patients with Primary Hyperparathyroidism
Machine Learning-derived Clinical Decision Algorithm for the Diagnosis of Hyperfunctioning Parathyroid Glands in Patients with Primary Hyperparathyroidism Open
Purpose In patients with primary hyperparathyroidism (PHPT), planning for parathyroid surgery currently relies on the synthesis of clinical, laboratory, and imaging data by the clinician. Machine learning may assist in analyzing and integr…
View article: Real-Time Split-Dose PET/CT-Guided Ablation Improves Colorectal Liver Metastasis Detection and Ablation Zone Margin Assessments without the Need for Repeated Contrast Injection
Real-Time Split-Dose PET/CT-Guided Ablation Improves Colorectal Liver Metastasis Detection and Ablation Zone Margin Assessments without the Need for Repeated Contrast Injection Open
Background: Real-time split-dose PET can identify the targeted colorectal liver metastasis (CLM) and eliminate the need for repeated contrast administration before and during thermal ablation (TA). This study aimed to assess the added valu…
View article: Initial Results of<sup>68</sup>Ga-FAPI-46 PET/MRI to Assess Response to Neoadjuvant Chemotherapy in Breast Cancer
Initial Results of<sup>68</sup>Ga-FAPI-46 PET/MRI to Assess Response to Neoadjuvant Chemotherapy in Breast Cancer Open
Improving imaging-based response after neoadjuvant chemotherapy (NAC) in breast cancer assessment could obviate histologic confirmation of pathologic complete response (pCR) and facilitate deescalation of chemotherapy or surgery. Fibroblas…
View article: Artificial intelligence and radiomics: fundamentals, applications, and challenges in immunotherapy
Artificial intelligence and radiomics: fundamentals, applications, and challenges in immunotherapy Open
Immunotherapy offers the potential for durable clinical benefit but calls into question the association between tumor size and outcome that currently forms the basis for imaging-guided treatment. Artificial intelligence (AI) and radiomics …
View article: Can 18F-FDG PET/CT Radiomics Features Predict Clinical Outcomes in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma?
Can 18F-FDG PET/CT Radiomics Features Predict Clinical Outcomes in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma? Open
This study aimed to assess the usefulness of radiomics features of 18F-FDG PET/CT in patients with locally advanced esophageal cancers (ESCC) in predicting outcomes such as clinical tumor (cT) and nodal (cN) categories, PET response to ind…
View article: Editorial: Breakthrough in Imaging-Guided Precision Medicine in Oncology
Editorial: Breakthrough in Imaging-Guided Precision Medicine in Oncology Open
EDITORIAL article Front. Oncol., 18 May 2022Sec. Cancer Imaging and Image-directed Interventions Volume 12 - 2022 | https://doi.org/10.3389/fonc.2022.908561
View article: Translating Molecules into Imaging—The Development of New PET Tracers for Patients with Melanoma
Translating Molecules into Imaging—The Development of New PET Tracers for Patients with Melanoma Open
Melanoma is a deadly disease that often exhibits relentless progression and can have both early and late metastases. Recent advances in immunotherapy and targeted therapy have dramatically increased patient survival for patients with melan…
View article: <sup>18</sup>F-FDG PET/CT for Posttreatment Surveillance Imaging of Patients with Stage III Merkel Cell Carcinoma
<sup>18</sup>F-FDG PET/CT for Posttreatment Surveillance Imaging of Patients with Stage III Merkel Cell Carcinoma Open
The purpose of this study was to investigate the diagnostic and prognostic value of 18F-FDG PET/CT for surveillance imaging in patients treated for stage III Merkel cell carcinoma (MCC). Methods: This retrospective study included 61 consec…
View article: Reply:
Reply: Open
We want to thank Drs Kadam and Dua for their thoughtful and interesting commentary on our article in a Letter to the Editor. We acknowledge that are different methods to evaluate the carotid artery (CA) position and define anatomic variati…
View article: Bronchial or Pulmonary Artery Chemoembolization for Unresectable and Unablatable Lung Metastases: A Phase I Clinical Trial
Bronchial or Pulmonary Artery Chemoembolization for Unresectable and Unablatable Lung Metastases: A Phase I Clinical Trial Open
Background Lung chemoembolization is an emerging treatment option for lung tumors, but the optimal embolic, drug, and technique are unknown. Purpose To determine the technical success rate and safety of bronchial or pulmonary artery chemoe…
View article: The Role of Cost-Effectiveness Analysis in Patient-Centered Cancer Care in the Era of Precision Medicine
The Role of Cost-Effectiveness Analysis in Patient-Centered Cancer Care in the Era of Precision Medicine Open
Over the last few decades, changes in diagnostic and treatment paradigms have greatly advanced cancer care and improved outcomes [...]
View article: Updated Trends in Imaging Practices for Pancreatic Neuroendocrine Tumors (PNETs): A Systematic Review and Meta-Analysis to Pave the Way for Standardization in the New Era of Big Data and Artificial Intelligence
Updated Trends in Imaging Practices for Pancreatic Neuroendocrine Tumors (PNETs): A Systematic Review and Meta-Analysis to Pave the Way for Standardization in the New Era of Big Data and Artificial Intelligence Open
Purpose Medical imaging plays a central and decisive role in guiding the management of patients with pancreatic neuroendocrine tumors (PNETs). Our aim was to synthesize all recent literature of PNETs, enabling a comparison of all imaging p…