Ranju Kharel Sitaula
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View article: Red Eye with Red Content in the Anterior Chamber: A Case Report of Buerger’s Disease
Red Eye with Red Content in the Anterior Chamber: A Case Report of Buerger’s Disease Open
Ocular involvement in Buerger’s disease is rare, with acute anterior uveitis (AAU) and hyphema being uncommon manifestations. We report a case of a 40-year-old male with Buerger’s disease presenting with AAU and hyphema. The patient presen…
View article: Unbiased metagenomic next generation sequencing to investigate possible infective etiologies of 2021 SHAPU outbreak in Nepal
Unbiased metagenomic next generation sequencing to investigate possible infective etiologies of 2021 SHAPU outbreak in Nepal Open
Background Seasonal Hyperacute Panuveitis (SHAPU) is a rare, rapidly progressive ocular disease that leads to severe vision loss. Its etiology remains uncertain and observed seasonal outbreaks have been temporally linked to white moths. Se…
View article: Landscape Heterogeneity and Changing Bioclimatic Parameters Link to Potential Expansion of <i>Gazalina chrysolopha</i> (Lepidoptera; Notodontidae) in Nepal: A Possible Bioagent for Seasonal Hyperacute Panuveitis ( <scp>SHAPU</scp> ) in South Asia
Landscape Heterogeneity and Changing Bioclimatic Parameters Link to Potential Expansion of <i>Gazalina chrysolopha</i> (Lepidoptera; Notodontidae) in Nepal: A Possible Bioagent for Seasonal Hyperacute Panuveitis ( <span>SHAPU</span> ) in South Asia Open
Seasonal hyperacute panuveitis (SHAPU) is an eye disease primarily reported in Nepal, especially in mid‐hill regions of central and western parts. Several clinical and entomological studies have identified Gazalina chrysolopha as the possi…
View article: Common data elements for observational studies in ocular toxoplasmosis: a Delphi consensus
Common data elements for observational studies in ocular toxoplasmosis: a Delphi consensus Open
View article: Evaluation of ganglion cell complex in patients taking hydroxychloroquine
Evaluation of ganglion cell complex in patients taking hydroxychloroquine Open
Background To evaluate the ganglion cell complex thickness in patients taking oral hydroxychloroquine. Methods In this hospital-based, cross-sectional, non-interventional, comparative study, 87 eyes of 87 patients taking hydroxychloroquine…
View article: Seasonal Hyperacute Panuveitis from the highest reported altitude: co-occurrence with scleritis – an unusual presentation
Seasonal Hyperacute Panuveitis from the highest reported altitude: co-occurrence with scleritis – an unusual presentation Open
SHAPU primarily affects the uveal tissue, but its spread of uveal inflammation to the scleral tissue must be borne in mind. This SHAPU case from a high altitude with intense ocular pain suggests new aspects of SHAPU's pathophysiology, cont…
View article: Programme for ocular inflammation & infection translational research (PROTON) registry: Cross-sectional analysis of baseline patient characteristics
Programme for ocular inflammation & infection translational research (PROTON) registry: Cross-sectional analysis of baseline patient characteristics Open
The PROTON registry provides valuable insights into the global spectrum of OID, with a substantial representation of infectious causes. This real-world evidence highlights the key prevalence of visual impairment and underscores the importa…
View article: Advanced diagnostic approaches for SHAPU: Metagenomic sequencing and interleukin analysis
Advanced diagnostic approaches for SHAPU: Metagenomic sequencing and interleukin analysis Open
Seasonal Hyperacute Panuveitis (SHAPU) is an ocular emergency where the genesis between infective and immunological is under investigation. This is the first report in the literature that attempts to explore the unidentified cause using ne…
View article: Beauty of Black and White: Autofluorescence-aided Differentiation of Serpiginous Choroiditis from Tubercular Serpiginous-Like Choroiditis
Beauty of Black and White: Autofluorescence-aided Differentiation of Serpiginous Choroiditis from Tubercular Serpiginous-Like Choroiditis Open
Introduction: FAF is non-invasive, and important adjunctive tool to evaluate the progression of lesions in patients with SC. FAF can even help distinguish probable etiology by specific pattern recognition. The current index study analyzed …
View article: Choroidal Thickness Measurement in Systemic Lupus Erythematosus Patients with or Without Ocular Manifestation
Choroidal Thickness Measurement in Systemic Lupus Erythematosus Patients with or Without Ocular Manifestation Open
Background: Systemic Lupus Erythematosus is a multi-systemic disease that has a high morbidity rate. Choroids usually have a distinct structural makeup in different systemic disorders which makes it easier to be used as a potential tool fo…
View article: Investigation of the causative pathogen in the 2023 conjunctivitis outbreak of Nepal using unbiased metagenomic next generation sequencing
Investigation of the causative pathogen in the 2023 conjunctivitis outbreak of Nepal using unbiased metagenomic next generation sequencing Open
In mid-2023, Nepal experienced a significant outbreak of conjunctivitis, affecting over 60% of outpatients in eye hospitals and prompting school closures. The outbreak, peaking in August, predominantly impacted children and individuals wit…
View article: Bruchs Membrane Opening Area Measurement in Healthy Nepalese Eyes
Bruchs Membrane Opening Area Measurement in Healthy Nepalese Eyes Open
Background: Bruch’s membrane opening area is the circular area around the disc of Bruch’s membrane, which is devoid of Bruch’s membrane and can be assessed by capturing the retinal imaging system by Spectral-domain optical coherence tomogr…
View article: Changes in Central Corneal Thickness, Corrected Intraocular Pressure, and Iridocorneal Angle in Unilateral Acute Anterior Uveitis
Changes in Central Corneal Thickness, Corrected Intraocular Pressure, and Iridocorneal Angle in Unilateral Acute Anterior Uveitis Open
Introduction: The release of inflammatory mediators in the anterior chamber can lead to the structural alteration of the corneal and uveal tissue. Objectives: To compare the changes in Central Corneal Thickness (CCT), corrected Intraocular…
View article: Case Report of Foveolitis with Optic Neuritis: A Barely encountered Ophthalmic Manifestation of Dengue
Case Report of Foveolitis with Optic Neuritis: A Barely encountered Ophthalmic Manifestation of Dengue Open
Dengue fever is a tropical disease which is endemic in tropical/subtropical nations like Nepal. Bilateral optic neuritis with unilateral foveolitis is an unusual dengue-related ophthalmic complication. We here present to you a case of bila…
View article: Systemic lupus erythematosus (SLE) associated uveitis in India – A case series
Systemic lupus erythematosus (SLE) associated uveitis in India – A case series Open
Purpose: To report the uveitic manifestations of patients with systemic lupus erythematosus (SLE). Methods: This was a retrospective analysis of all SLE cases with ocular manifestations seen by a single ophthalmologist between 2015 and Dec…
View article: Ocular Manifestations in Patients with Extrapulmonary Tuberculosis
Ocular Manifestations in Patients with Extrapulmonary Tuberculosis Open
Introduction : The study was done to find out the ocular manifestation in patients with extrapulmonary tuberculosis visiting a tertiary eye centre. Methods: A hospital based descriptive observational study was done among newly diagnosed ex…
View article: The Risk Factors of Seasonal Hyperacute Panuveitis
The Risk Factors of Seasonal Hyperacute Panuveitis Open
Background: Seasonal Hyperacute Panuveitis (SHAPU) is an eye disease of unclear aetiology occurring cyclically during the autumn in odd years in Nepal causing blindness within a week. This study is the first of its type to investigate the …
View article: Endogenous endophthalmitis in post-COVID-19 patients: a case report
Endogenous endophthalmitis in post-COVID-19 patients: a case report Open
Introduction and importance: Ocular involvement in coronavirus disease 2019 (COVID-19) can be due to direct viral invasion or indirectly due to an immunosuppressed state. Prolonged hospitalization also makes them susceptible to various sec…
View article: Frosted branched angiitis due to viral meningo-encephalitis and ocular toxoplasmosis; a rare case report from Nepal
Frosted branched angiitis due to viral meningo-encephalitis and ocular toxoplasmosis; a rare case report from Nepal Open
Introduction: Frosted branched angiitis (FBA) is characteristic florid translucent retinal perivascular sheathing of both arterioles and venules in association with variable uveitis and vasculitis affecting the entire retina. The vascular …
View article: Case report peripheral ulcerative keratitis with nodular scleritis, presents as the primary manifestation of granulomatosis with polyangiitis
Case report peripheral ulcerative keratitis with nodular scleritis, presents as the primary manifestation of granulomatosis with polyangiitis Open
Introduction and importance: Granulomatosis with polyangiitis (GPA) is an ANCA-associated autoimmune disorder that typically affects small and/or medium-sized blood vessels. Being a life-threatening disease, with timely suspicion, targeted…
View article: The pattern of sarcoid uveitis at a tertiary care center in Nepal
The pattern of sarcoid uveitis at a tertiary care center in Nepal Open
Introduction: Sarcoidosis is an idiopathic, multisystemic granulomatous disorder involving the eye with various ocular presentations, the most common being sarcoid uveitis. The diagnosis was based on typical clinical features, chest radiog…
View article: A case of oculocutaneous sarcoidosis
A case of oculocutaneous sarcoidosis Open
View article: Rise of biologics in noninfectious uveitis: a retrospective cohort study from Nepal
Rise of biologics in noninfectious uveitis: a retrospective cohort study from Nepal Open
Background: Uveitis is a sight-threatening disease that poses a heavy burden on the quality of life. The treatment of uveitis has been revolutionized in the past two decades. Most remarkable among these is the emergence of biologics, which…
View article: Role of multimodal imaging in differentiating unilateral APMPPE from unilateral Harada disease – a case report
Role of multimodal imaging in differentiating unilateral APMPPE from unilateral Harada disease – a case report Open
Introduction and importance: Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is classified as a part of the spectrum of the white dot syndromes affecting the inner choroid and the outer retina. It is usually bilateral an…
View article: The role of a multicentre data repository in ocular inflammation: The Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS)
The role of a multicentre data repository in ocular inflammation: The Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) Open
View article: Ocular toxicity among patients taking anti-tubercular treatment
Ocular toxicity among patients taking anti-tubercular treatment Open
Introduction: Tuberculosis remains a major public health problem in Nepal and anti-tubercular drugs used for the treatment of pulmonary and extrapulmonary tuberculosis can be associated with ocular toxicity. This prospective study aimed to…
View article: Scleritis as the harbinger of Granulomatosis with polyangiitis
Scleritis as the harbinger of Granulomatosis with polyangiitis Open
Scleritis could be manifesting feature of GPA so cautious history taking and evaluation is important. Management often requires multidisciplinary care and ocular features could be the reference guidelines to adjust dose of systemic medicat…
View article: Visual Impact of Digital Classroom among Students Attending Online Education.
Visual Impact of Digital Classroom among Students Attending Online Education. Open
Ocular symptoms and digital eye strain related to the excessive use of digital devices have increased due to the increased duration of online classes. Awareness about the prevention and measures to reduce the adverse effects should be stre…
View article: Tubercular Harada disease – An unreported uveitic entity
Tubercular Harada disease – An unreported uveitic entity Open
Mycobacterium could have triggered the onset of Harada disease in TB endemic country like Nepal leading to simultaneous presentation of Tubercular Harada Disease.
View article: Does outer retinal layer thickness correlate with the central visual field indices in early dry age-related macular degeneration?
Does outer retinal layer thickness correlate with the central visual field indices in early dry age-related macular degeneration? Open
PURPOSE: Age-related macular degeneration (ARMD) is the leading cause of irreversible blindness worldwide and Nepal is one among them. We aimed to determine the relationship between outer retinal layer thickness parameters with central vis…