Ranran Lu
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View article: An Integrated Random Forest– and LASSO-Derived Nomogram for Predicting Postoperative Nosocomial Infections in Colorectal Cancer Patients
An Integrated Random Forest– and LASSO-Derived Nomogram for Predicting Postoperative Nosocomial Infections in Colorectal Cancer Patients Open
Objective We sought to delineate the independent risk factors underlying postoperative nosocomial infections in colorectal cancer patients and to construct and validate a nomogram for individualized risk prediction, thereby enabling early …
View article: Distinct deformation mechanisms of silicate glasses under nanoindentation: The critical role of structure
Distinct deformation mechanisms of silicate glasses under nanoindentation: The critical role of structure Open
We use large-scale molecular dynamics simulations to investigate the indentation response of three silica-based glasses with varying compositional complexities. Our primary goal is to clarify the roles of the typical network-modifying spec…
View article: No association between genetically predicted vitamin D levels and Parkinson’s disease
No association between genetically predicted vitamin D levels and Parkinson’s disease Open
Background Parkinson’s disease (PD) is a neurodegenerative disorder, primarily characterized by motor impairments. Vitamin D has several regulatory functions in nerve cell survival and gene expression via its receptors. Although research h…
View article: Nrf2 Deficiency Exacerbates Parkinson’s Disease by Aggravating NLRP3 Inflammasome Activation in MPTP-Induced Mouse Models and LPS-Induced BV2 Cells
Nrf2 Deficiency Exacerbates Parkinson’s Disease by Aggravating NLRP3 Inflammasome Activation in MPTP-Induced Mouse Models and LPS-Induced BV2 Cells Open
Inhibited Nrf2 activity can reduce the downstream antioxidant enzyme HO-1 and antioxidant levels, induce NLRP3 inflammasome activation and ASC protein assembly in microglia, and ultimately aggravate PD inflammatory response and dopamine ne…
View article: The two-component system TtrRS boosts Vibrio parahaemolyticus colonization by exploiting sulfur compounds in host gut
The two-component system TtrRS boosts Vibrio parahaemolyticus colonization by exploiting sulfur compounds in host gut Open
One of the greatest challenges encountered by enteric pathogens is responding to rapid changes of nutrient availability in host. However, the mechanisms by which pathogens sense gastrointestinal signals and exploit available host nutrients…
View article: Nanoindentation-induced evolution of atomic-level properties in silicate glass: Insights from molecular dynamics simulations
Nanoindentation-induced evolution of atomic-level properties in silicate glass: Insights from molecular dynamics simulations Open
Indentation has been widely used for investigating the mechanical behavior of glasses. However, how the various microscopic properties (such as atomic structure and mechanics) of glass evolve from the immediate contact with the indenter to…
View article: Interaction between autophagy and the NLRP3 inflammasome in Alzheimer’s and Parkinson’s disease
Interaction between autophagy and the NLRP3 inflammasome in Alzheimer’s and Parkinson’s disease Open
Autophagy degrades phagocytosed damaged organelles, misfolded proteins, and various pathogens through lysosomes as an essential way to maintain cellular homeostasis. Autophagy is a tightly regulated cellular self-degradation process that p…
View article: Beneficial Effects of Jujube Juice Fermented by Lactobacillus plantarum NXU19009 on Acute Alcoholic Liver Injury in Mice
Beneficial Effects of Jujube Juice Fermented by Lactobacillus plantarum NXU19009 on Acute Alcoholic Liver Injury in Mice Open
Red jujube (Ziziphus jujuba Mill.) is an important fruit that has the concomitant function of both medicine and food. It has been proven to be rich in various bioactive components. In the present study, jujube juice was fermented by Lactob…
View article: Identification of LuxR Family Regulators That Integrate Into Quorum Sensing Circuit in Vibrio parahaemolyticus
Identification of LuxR Family Regulators That Integrate Into Quorum Sensing Circuit in Vibrio parahaemolyticus Open
Vibrio parahaemolyticus is one of the most important food-borne pathogens that cause economic and public health problems worldwide. Quorum sensing (QS) is a way for the cell-cell communication between bacteria that controls a wide spectrum…