Ranran Tang
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View article: GENEasso: a curated resource of credible disease–gene associations across complex diseases from GWAS summary statistics
GENEasso: a curated resource of credible disease–gene associations across complex diseases from GWAS summary statistics Open
Gene-based association analysis has become a powerful strategy to improve the biological interpretability of genome-wide association studies (GWAS) by aggregating variant-level signals at the gene level. Although several transcriptome-wide…
View article: CROT overactivation within peroxisomes confers chemoresistance to non-small cell lung cancer by targeting fatty acid oxidation-Nrf2-ferroptosis resistance axis
CROT overactivation within peroxisomes confers chemoresistance to non-small cell lung cancer by targeting fatty acid oxidation-Nrf2-ferroptosis resistance axis Open
A key factor that limits the therapeutic benefits for non-small cell lung cancer (NSCLC) patients is chemoresistance. Even so, a detailed understanding of the process involved in chemoresistance acquisition and development at molecular lev…
View article: Correction: Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits
Correction: Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits Open
identified errors in Figure 3c and Figure 5e.The merged image of VE group in sk-mel-28 cells (Fig. 3C) and the image of DMSO + NC group in A375 cells (Fig. 5E) has been mistakenly uploaded, respectively.
View article: KMT2A facilitates the epithelial-to-mesenchymal transition and the progression of ovarian cancer
KMT2A facilitates the epithelial-to-mesenchymal transition and the progression of ovarian cancer Open
Background Epithelial-mesenchymal transition (EMT) plays critical roles in cancer progression and metastasis. Thus, the exploration of the molecular mechanism regulating EMT would provide potential opportunities for the therapy of metastat…
View article: <scp>LINC00629</scp>, a <scp>HOXB4</scp>‐downregulated long noncoding <scp>RNA</scp>, inhibits glycolysis and ovarian cancer progression by destabilizing <scp>c‐Myc</scp>
<span>LINC00629</span>, a <span>HOXB4</span>‐downregulated long noncoding <span>RNA</span>, inhibits glycolysis and ovarian cancer progression by destabilizing <span>c‐Myc</span> Open
Ovarian cancer (OC) cells typically reprogram their metabolism to promote rapid proliferation. However, the role of long noncoding RNAs (lncRNAs) in the metabolic reprogramming of ovarian cancer, especially in glucose metabolic reprogrammi…
View article: Sulfur-regulated metal–support interaction boosting the hydrogen evolution performance of Ru clusters in seawater at industrial current densities
Sulfur-regulated metal–support interaction boosting the hydrogen evolution performance of Ru clusters in seawater at industrial current densities Open
Ru nanocluster-anchored sulfur and nitrogen co-doped carbon hollow spheres exhibit high hydrogen evolution reaction performance in alkaline real seawater.
View article: Rational Design of Heterostructured Ru Cluster‐Based Catalyst for pH Universal Hydrogen Evolution Reaction and High‐Performance Zn‐H<sub>2</sub>O Battery
Rational Design of Heterostructured Ru Cluster‐Based Catalyst for pH Universal Hydrogen Evolution Reaction and High‐Performance Zn‐H<sub>2</sub>O Battery Open
Ruthenium (Ru) is an ideal substitute to commercial Pt/C for hydrogen evolution reaction (HER). Reducing the size of Ru to clusters can greatly increase the utilization of atoms, however, over‐strong RuH binding will be brought about. Add…
View article: A Novel Autophagy-related Genes Signature Regulates the Differentiation Trajectory and Immune Landscape of Glioblastoma
A Novel Autophagy-related Genes Signature Regulates the Differentiation Trajectory and Immune Landscape of Glioblastoma Open
The regulatory role of autophagy-related genes (ARGs) on the differentiation trajectory and immune landscape of glioblastoma remained obscure. This research identified 11 ARGs differentially expressed in glioblastomas; LASSO and Binomial r…
View article: The function and possible mechanism of lncRNA LINC00881 in regulating fetal growth restriction
The function and possible mechanism of lncRNA LINC00881 in regulating fetal growth restriction Open
Background: Long noncoding RNAs (lncRNAs) were found to play important roles in the pathogenesis of FGR. Herein, we aimed to elucidate the role of LINC00881 in regulating various biological events of FGR. Methods: LINC00881 expression leve…
View article: Comprehensive Analysis of lncRNA and miRNA Regulatory Network Reveals Potential Prognostic Non-coding RNA Involved in Breast Cancer Progression
Comprehensive Analysis of lncRNA and miRNA Regulatory Network Reveals Potential Prognostic Non-coding RNA Involved in Breast Cancer Progression Open
Breast cancer is one of the most common malignant tumors in women and is the second leading cause of cancer deaths among women. The tumorigenesis and progression of breast cancer are not well understood. The existing researches have indica…
View article: RETRACTED: LBX2‐AS1 promotes ovarian cancer progression by facilitating E2F2 gene expression via miR‐455‐5p and miR‐491‐5p sponging
RETRACTED: LBX2‐AS1 promotes ovarian cancer progression by facilitating E2F2 gene expression via miR‐455‐5p and miR‐491‐5p sponging Open
LBX2‐AS1 is a long non‐coding RNA that facilitates the development of gastrointestinal cancers and lung cancer, but its participation in ovarian cancer development remained uninvestigated. Clinical data retrieved from TCGA ovarian cancer d…
View article: Melatonin synergizes BRAF‐targeting agent dabrafenib for the treatment of anaplastic thyroid cancer by inhibiting AKT/hTERT signalling
Melatonin synergizes BRAF‐targeting agent dabrafenib for the treatment of anaplastic thyroid cancer by inhibiting AKT/hTERT signalling Open
As a selective inhibitor of BRAF kinase, dabrafenib has shown potent anti‐tumour activities in patients with BRAFV600E mutant anaplastic thyroid cancer. However, the resistance of thyroid cancer cells to dabrafenib limited its therapeutic …
View article: LBX2-AS1 Promotes Ovarian Cancer Progression by Facilitating E2F2 Gene Expression via MIR-455-5P and MIR-491-5P Sponging
LBX2-AS1 Promotes Ovarian Cancer Progression by Facilitating E2F2 Gene Expression via MIR-455-5P and MIR-491-5P Sponging Open
Background: LBX2-AS1 is a long noncoding RNA that facilitates the development of gastrointestinal cancers and lung cancer, but its participation in ovarian cancer development remained uninvestigated. Methods: Clinical data retrieved from T…
View article: A comprehensive analysis of IDO1 expression with tumour‐infiltrating immune cells and mutation burden in gynaecologic and breast cancers
A comprehensive analysis of IDO1 expression with tumour‐infiltrating immune cells and mutation burden in gynaecologic and breast cancers Open
Gynaecologic and breast cancers share some similarities at the molecular level. The aims of our study are to highlight the similarities and differences about IDO1, an important immune‐related gene in female cancers. The NGS data from TCGA …
View article: Effects of Aberrant miR-384-5p Expression on Learning and Memory in a Rat Model of Attention Deficit Hyperactivity Disorder
Effects of Aberrant miR-384-5p Expression on Learning and Memory in a Rat Model of Attention Deficit Hyperactivity Disorder Open
Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric disorder characterized by inattention, hyperactivity, and impulsivity. It may be accompanied by learning difficulties and working memory deficits. Few studies hav…
View article: GAS5, a FoxO1-actived long noncoding RNA, promotes propofol-induced oral squamous cell carcinoma apoptosis by regulating the miR-1297-GSK3β axis
GAS5, a FoxO1-actived long noncoding RNA, promotes propofol-induced oral squamous cell carcinoma apoptosis by regulating the miR-1297-GSK3β axis Open
Propofol, an intravenous anaesthetic agent, has been found to exhibit antitumour effects in various kinds of cancer cells. However, the potential roles and regulatory mechanisms of propofol in oral squamous cell carcinoma (OSCC) remain unk…
View article: A Multifunctional Biodegradable Nanocomposite for Cancer Theranostics
A Multifunctional Biodegradable Nanocomposite for Cancer Theranostics Open
Theranostic formulations, integrating both diagnostic and therapeutic functions into a single platform, hold great potential for precision medicines. In this work, a biodegradable theranostic based on hollow mesoporous organosilica nanopar…
View article: Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits
Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits Open
Background As the selective inhibitor of BRAF kinase, vemurafenib exhibits effective antitumor activities in patients with V600 BRAF mutant melanomas. However, acquired drug resistance invariably develops after its initial treatment. Metho…
View article: BPTF cooperates with p50 NF-κB to promote COX-2 expression and tumor cell growth in lung cancer.
BPTF cooperates with p50 NF-κB to promote COX-2 expression and tumor cell growth in lung cancer. Open
Cyclooxygenase-2 (COX-2) is overexpressed in most human cancers, but its precise regulatory mechanism in cancer cells remains unclear. The aims of this study are to discover and identify the new regulatory factors which bind to the COX-2 p…
View article: MicroRNA-3666 inhibits lung cancer cell proliferation, migration, and invasiveness by targeting BPTF
MicroRNA-3666 inhibits lung cancer cell proliferation, migration, and invasiveness by targeting BPTF Open
A previous study by our group indicted that overexpression of bromodomain PHD-finger transcription factor (BPTF) occurs in lung adenocarcinoma, and is closely associated with advanced clinical stage, higher numbers of metastatic lymph node…
View article: Downregulation of NMI promotes tumor growth and predicts poor prognosis in human lung adenocarcinomas
Downregulation of NMI promotes tumor growth and predicts poor prognosis in human lung adenocarcinomas Open
Our study showed that NMI suppressed tumor growth by inhibiting PI3K/AKT, MMP2/MMP9, COX-2/PGE2 signaling pathways and p300-mediated NF-κB acetylation, and predicted a favorable prognosis in human lung adenocarcinomas, suggesting that NMI …
View article: KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway
KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway Open
Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as a potential target, which promoted the growth of human melan…
View article: NMI inhibits cancer stem cell traits by downregulating hTERT in breast cancer
NMI inhibits cancer stem cell traits by downregulating hTERT in breast cancer Open
N-myc and STAT interactor (NMI) has been proved to bind to different transcription factors to regulate a variety of signaling mechanisms including DNA damage, cell cycle and epithelial–mesenchymal transition. However, the role of NMI in th…
View article: Genetic factors associated with risk of metabolic syndrome and hepatocellular carcinoma
Genetic factors associated with risk of metabolic syndrome and hepatocellular carcinoma Open
Although the metabolic syndrome is a commonplace topic, its potential threats to public health is a problem that cannot be neglected. As the living conditions improved significantly over the past few years, the morbidity of metabolic syndr…
View article: YBX1 regulates tumor growth via CDC25a pathway in human lung adenocarcinoma
YBX1 regulates tumor growth via CDC25a pathway in human lung adenocarcinoma Open
Y-box binding protein 1 (YBX1) is involved in the multi-tumor occurrence and development. However, the regulation of YBX1 in lung tumorigenesis and the underlying mechanisms, especially its relationship with CDC25a, was remains unclear. In…