Explanipedia

An Elastocaloric Polymer with Ultra-High Solid-State Cooling via Defect Engineering Open

Zhaohan Yu, Duo Xu, Zumrat Usmanova, Chuwei Ye, Abhishek Swarnkar , et al. · 2025

Elastocaloric polymers, whose performance typically rely on phase transformation between amorphous chains and crystalline domains, offer a promising alternative to traditional refrigeration technologies. While engineering polymer-network a…

Enhanced inhibition of neuronal ferroptosis and regulation of microglial polarization with multifunctional traditional Chinese medicine active ingredients-based selenium nanoparticles for treating spinal cord injury Open

Luoqi Mai, Jinggong Liu, Huimei Wu, Hongshen Wang, Zhidong Lin , et al. · 2025

Self‐Enhancing Drug Pair‐Driven Selenium Nanotherapeutics Reverses Microglial Pyroptosis Through NLRP3/Caspase‐1 Pathway and Neuronal Apoptosis for Treatment of Spinal Cord Injury Open

Jinggong Liu, Luoqi Mai, Aaron C. Tan, Yanxin Du, Jieyi Luo , et al. · 2025

Spinal cord injury (SCI) constitutes a critical occurrence that results in the disruption of both motor and sensory functions. Oxidative stress‐induced apoptosis and pyroptosis have been identified as critical contributors to neuronal dama…

Impact of Topological Defects on Strain-Induced Crystallization in Elastocaloric Polymers Open

Shaoting Lin, Zhaohan Yu, Duo Xu, Zumrat Usmanova, Abhishek Swarnkar , et al. · 2025

Elastocaloric polymers, whose performance typically relies on phase transformation between amorphous chains and crystalline domains, offer a promising alternative to traditional refrigeration technologies due to their solid-state character…

Anisotropic hydrogel microelectrodes for intraspinal neural recordings in vivo Open

Sizhe Huang, Ruobai Xiao, Shaoting Lin, Z. Y. Wu, Lin Chen , et al. · 2025

Creating durable, motion-compliant neural interfaces is crucial for accessing dynamic tissues under in vivo conditions and linking neural activity with behaviors. Utilizing the self-alignment of nano-fillers in a polymeric matrix under rep…

Anisotropic Hydrogel Microelectrodes for Intraspinal Neural Recordings in vivo Open

Siyuan Rao, Sizhe Huang, Ruobai Xiao, Shaoting Lin, Eunji Hong , et al. · 2024

Creating durable, motion-compliant neural interfaces is crucial for accessing dynamic tissues under in vivo conditions and linking neural activity with behaviors. Utilizing the self-alignment of nano-fillers in a polymeric matrix under rep…

Control of polymers’ amorphous-crystalline transition enables miniaturization and multifunctional integration for hydrogel bioelectronics Open

Sizhe Huang, Xinyue Liu, Shaoting Lin, Christopher Glynn, Kayla Felix , et al. · 2024

Biologically Driven In Vivo Occlusion Design Provides a Reliable Experimental Glaucoma Model Open

Eunji Hong, Tian Feng, C. J. Glynn, Sophia Tsekov, Sizhe Huang , et al. · 2024

Fluid flow transport through the trabecular meshwork tissues is a major regulator of intraocular pressure (IOP) modulation in healthy and glaucomatous individuals. Microbead occlusion models of ocular hypertension regulate aqueous humor dr…

An Esterase-Activatable Nanoprodrug Mitigates Severe Spinal Cord Injury Via Alleviating Ferroptosis and Reprogramming Inflammatory Microenvironment Open

Jinggong Liu, Yanzhou Chang, Wen Zhou, Siyuan Rao, Hongshen Wang , et al. · 2024

Fatigue-resistant hydrogel optical fibers enable peripheral nerve optogenetics during locomotion Open

Xinyue Liu, Siyuan Rao, Weixuan Chen, Kayla Felix, Jiahua Ni , et al. · 2023

Control of Polymers’ Amorphous-crystalline Transition for Hydrogel Bioelectronics Miniaturization and Multifunctional Integration Open

Siyuan Rao, Sizhe Huang, Xinyue Liu, Shaoting Lin, C. J. Glynn , et al. · 2023

Bioelectronic devices made of soft elastic materials exhibit motion-adaptive properties suitable for brain-machine interfaces and for investigating complex neural circuits. While two-dimensional microfabrication strategies enable miniaturi…

A nanoscale inorganic coating strategy for stabilizing hydrogel neural probes <i>in vivo</i> Open

Sizhe Huang, Sabrina Urbina Villafranca, I. K. Mehta, Omri Yosfan, Eunji Hong , et al. · 2023

Hydrogels with adaptable optical and mechanical characteristics show considerable promise for light delivery in vivo with neuroengineering applications.

Non-Invasive Electroretinogram Recording with Simultaneous Optogenetics to Dissect Retinal Ganglion Cells Electrophysiological Dynamics Open

Eunji Hong, C. J. Glynn, Qianbin Wang, Siyuan Rao · 2022

Electroretinography (ERG) is a non-invasive electrophysiological recording technique that detects the electrical signaling of neuronal cells in the visual system. In conventional ERG recordings, the signals are considered a collective elec…

Traditional Chinese medicine active ingredients-based selenium nanoparticles regulate antioxidant selenoproteins for spinal cord injury treatment Open

Siyuan Rao, Yongpeng Lin, Rui Lin, Jinggong Liu, Hongshen Wang , et al. · 2022

Remotely controlled magnetic stimulation with localized chemical release Open

Siyuan Rao · 2021

Thoracic full-endoscopic unilateral laminotomy with bilateral decompression for treating ossification of the ligamentum flavum with myelopathy Open

Yong-Peng Lin, Rui Lin, Song Chen, Siyuan Rao, Shuai Zhao , et al. · 2021

TE-ULBD is safe and effective for thoracic OLF with the advantages of reduced trauma and bleeding, and faster recovery.

Material Engineering Platform for Next Generation of Neurobiological Interfaces Open

Siyuan Rao, Jingyi Qiu · 2021

ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTMaterial Engineering Platform for Next Generation of Neurobiological InterfacesSiyuan Rao*Siyuan RaoDepartment of Biomedical Engineering, University of Massachusetts Amherst, Amherst, Massachus…

Electromagnetic navigation-assisted percutaneous endoscopic foraminoplasty and discectomy for lumbar disc herniation: technical note and preliminary results Open

Yong-Peng Lin, Siyuan Rao, Bolai Chen, Binde Zhao, Tao Wen , et al. · 2020

Electromagnetic navigation system-assisted percutaneous full-endoscopic foraminoplasty and discectomy is a safe and effective method for treating LDH and this method has the advantage of short operative time and fluoroscopic times.

Magnetothermal Multiplexing for Selective Remote Control of Cell Signaling Open

Junsang Moon, Michael G. Christiansen, Siyuan Rao, Colin Marcus, David Bono , et al. · 2020

Magnetic nanoparticles have garnered sustained research interest for their promise in biomedical applications including diagnostic imaging, triggered drug release, cancer hyperthermia, and neural stimulation. Many of these applications mak…

In situ electrochemical generation of nitric oxide for neuronal modulation Open

Jimin Park, Kyoungsuk Jin, Atharva Sahasrabudhe, Po‐Han Chiang, Joseph Maalouf , et al. · 2020

Effect of Electromagnetic Navigation System Assisted Percutaneous Full-endoscopic Foraminoplasty and Discectomy on Lumbar Disc Herniation: A Randomized Controlled Trial Open

Yong-Peng Lin, Siyuan Rao, YongJin Li, Binde Zhao, Tao Wen , et al. · 2020

Background Electromagnetic navigation-guided technique is an exciting innovative procedure, which has been applied in neurosurgery, otolaryngology, oral and maxillofacial surgery, etc. However, no previous study of the application of elect…

Functionally Distinct Neuronal Ensembles within the Memory Engram Open

Xiaochen Sun, Max J. Bernstein, Meizhen Meng, Siyuan Rao, Andreas T. Sørensen , et al. · 2020

Flexible and stretchable nanowire-coated fibers for optoelectronic probing of spinal cord circuits Open

Chi Lu, Seongjun Park, Thomas J. Richner, Alexander Derry, Imogen Brown , et al. · 2017

Stretchable optoelectronic fibers interrogate spinal cord circuits during free behavior.

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