Rapee Trichavaroj
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View article: Vaccine Induced Seroreactivity Following Administration of ALVAC-HIV/AIDSVAX®B/E Identified by Common Anti-HIV Test Kits and Algorithms in Thailand
Vaccine Induced Seroreactivity Following Administration of ALVAC-HIV/AIDSVAX®B/E Identified by Common Anti-HIV Test Kits and Algorithms in Thailand Open
Vaccine-induced seroreactivity (VISR) was evaluated in RV306 and was shown to vary markedly (0–32.5%) among 6 HIV diagnostic tests and 84 algorithms. Our data show that selecting the SD Bioline HIV-1/2 assay and algorithms which exclude th…
View article: No significant drug−drug interaction between oral TAF‐based PrEP and feminizing hormone therapy among transgender women in Thailand: the iFACT‐3 study
No significant drug−drug interaction between oral TAF‐based PrEP and feminizing hormone therapy among transgender women in Thailand: the iFACT‐3 study Open
Introduction Concerns regarding potential drug−drug interaction (DDI) between feminizing hormone therapy (FHT) and HIV pre‐exposure prophylaxis (PrEP) may hinder PrEP use among transgender women. We assessed the potential DDI between FHT a…
View article: Exploring potential drug−drug interactions between masculinizing hormone therapy and oral pre‐exposure prophylaxis (F/TDF and F/TAF) among transgender men (iMACT study): a randomized, open‐label pharmacokinetic study in Thailand
Exploring potential drug−drug interactions between masculinizing hormone therapy and oral pre‐exposure prophylaxis (F/TDF and F/TAF) among transgender men (iMACT study): a randomized, open‐label pharmacokinetic study in Thailand Open
Introduction Concerns regarding potential drug−drug interactions (DDIs) between hormone therapy and pre‐exposure prophylaxis (PrEP) may hinder PrEP use among transgender persons. Transgender men have often been overlooked in biomedical HIV…
View article: Initial productive and latent HIV infections originate in vivo by infection of resting T cells
Initial productive and latent HIV infections originate in vivo by infection of resting T cells Open
Productively infected cells are generally thought to arise from HIV infection of activated CD4+ T cells, and these infected activated cells are thought to be a recurring source of latently infected cells when a portion of the population tr…
View article: Productive and latent HIV infections originate in resting CD4<sup>+</sup>T cells
Productive and latent HIV infections originate in resting CD4<sup>+</sup>T cells Open
Summary Productively and latently HIV-infected cells are the source of virus that respectively establishes and sustains systemic infections and the reservoir in which HIV persists and rebounds when anti-retroviral therapy (ART) is interrup…
View article: Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection
Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection Open
Starting antiretroviral therapy (ART) in Fiebig 1 acute HIV infection limits the size of viral reservoirs in lymphoid tissues, but does not impact time to virus rebound during a treatment interruption. To better understand why the reduced …
View article: Brief Report: Prevalence Trend of Transmitted Drug Resistance in a Prospective Cohort of Thai People With Acute HIV Infection
Brief Report: Prevalence Trend of Transmitted Drug Resistance in a Prospective Cohort of Thai People With Acute HIV Infection Open
Background: The greater availability of different antiretroviral therapy regimens in developing countries may influence the emergence of transmitted drug resistance (TDR). People with acute HIV infection (AHI) represent the best opportunit…
View article: Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection
Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection Open
We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with F…
View article: Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection
Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection Open
Although a large pool of cells is infected during acute HIV infection, most of these early targets are rapidly cleared upon ART initiation.
View article: Late boosting of the RV144 regimen with AIDSVAX B/E and ALVAC-HIV in HIV-uninfected Thai volunteers: a double-blind, randomised controlled trial
Late boosting of the RV144 regimen with AIDSVAX B/E and ALVAC-HIV in HIV-uninfected Thai volunteers: a double-blind, randomised controlled trial Open
View article: Plasmacytoid dendritic cells sense HIV replication before detectable viremia following treatment interruption
Plasmacytoid dendritic cells sense HIV replication before detectable viremia following treatment interruption Open
Plasmacytoid dendritic cells (pDCs) are robust producers of IFNα and one of the first immune cells to respond to SIV infection. To elucidate responses to early HIV-1 replication, we studied blood pDCs in 29 HIV-infected participants who in…
View article: Liver function test abnormalities in a longitudinal cohort of Thai individuals treated since acute HIV infection
Liver function test abnormalities in a longitudinal cohort of Thai individuals treated since acute HIV infection Open
Introduction Liver disease is a common cause of non‐AIDS morbidity and mortality in people living with HIV (PLHIV), but the prevalence and significance of liver function test (LFT) abnormalities in early HIV infection is unknown. This stud…
View article: Viral Blips After Treatment Initiation During Acute Human Immunodeficiency Virus Infection
Viral Blips After Treatment Initiation During Acute Human Immunodeficiency Virus Infection Open
Transient viral blips ≥20 copies/mL were observed in 16.9% of acutely treated adults with HIV. Blip incidence increased from 0.0 (95% CI, 0.0–2.9)/100 person-years after ART in Fiebig I to 15.9 (7.6–29.2) in Fiebig V. Increasing viral load…
View article: Impact of Acute HIV Infection and Early Antiretroviral Therapy on the Human Gut Microbiome
Impact of Acute HIV Infection and Early Antiretroviral Therapy on the Human Gut Microbiome Open
Background Intestinal microbial dysbiosis is evident in chronic HIV-infected individuals and may underlie inflammation that persists even during antiretroviral therapy (ART). It remains unclear, however, how early after HIV infection gut d…
View article: Switch to dolutegravir is well tolerated in Thais with <scp>HIV</scp> infection
Switch to dolutegravir is well tolerated in Thais with <span>HIV</span> infection Open
Introduction Dolutegravir ( DTG ) is recommended as part of first‐line antiretroviral therapy ( ART ) for people living with HIV (PLHIV). We sought to determine the rate of adverse events ( AE s) and discontinuations among Thais treated du…
View article: Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial
Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial Open
View article: Transmission dynamics among participants initiating antiretroviral therapy upon diagnosis of early acute HIV-1 infection in Thailand
Transmission dynamics among participants initiating antiretroviral therapy upon diagnosis of early acute HIV-1 infection in Thailand Open
Despite high rates of viral suppression following diagnosis and treatment of AHI within a cohort of young Thai MSM, HIV-1 transmission continued, reflecting the need to expand awareness and treatment access to the entire MSM population.
View article: Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection Open
View article: Normalization of Soluble CD163 Levels After Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities
Normalization of Soluble CD163 Levels After Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities Open
Initiation of cART early during acute HIV infection (ie, during Fiebig stage I/II) may decrease inflammation, preventing shedding of CD163, which in turn might lower the risk of brain injury.
View article: Acute Retroviral Syndrome Is Associated With High Viral Burden, CD4 Depletion, and Immune Activation in Systemic and Tissue Compartments
Acute Retroviral Syndrome Is Associated With High Viral Burden, CD4 Depletion, and Immune Activation in Systemic and Tissue Compartments Open
ARS was associated with high viral burden, CD4 depletion, and immune activation across multiple body compartments during AHI and prior to ART. Persistent inflammation despite suppressive ART could contribute to increased morbidity in indiv…
View article: Identification of Acute HIV-1 Infection by Hologic Aptima HIV-1 RNA Qualitative Assay
Identification of Acute HIV-1 Infection by Hologic Aptima HIV-1 RNA Qualitative Assay Open
The Hologic Aptima HIV-1 Qualitative RNA assay was used in a rigorous screening approach designed to identify individuals at the earliest stage of HIV-1 infection for enrollment into subsequent studies of cellular and viral events in early…
View article: Viral kinetics in untreated versus treated acute HIV infection in prospective cohort studies in Thailand
Viral kinetics in untreated versus treated acute HIV infection in prospective cohort studies in Thailand Open
Introduction : The extent of viral replication during acute HIV infection (AHI) influences HIV disease progression. However, information comparing viral load (VL) kinetics with and without antiretroviral therapy (ART) in AHI is limited. Th…
View article: Altered Memory Circulating T Follicular Helper-B Cell Interaction in Early Acute HIV Infection
Altered Memory Circulating T Follicular Helper-B Cell Interaction in Early Acute HIV Infection Open
The RV254 cohort of HIV-infected very early acute (4thG stage 1 and 2) (stage 1/2) and late acute (4thG stage 3) (stage 3) individuals was used to study T helper- B cell responses in acute HIV infection and the impact of early antiretrovir…
View article: Declining trend in transmitted drug resistance detected in a prospective cohort study of acute HIV infection in Bangkok, Thailand
Declining trend in transmitted drug resistance detected in a prospective cohort study of acute HIV infection in Bangkok, Thailand Open
Introduction As availability of antiretroviral therapy expands in developing countries, the risk for transmission of drug‐resistant HIV also increases. Patients with acute HIV infection (AHI) provide an opportunity for real‐time monitoring…
View article: Virological and immunological characteristics of HIV-infected individuals at the earliest stage of infection
Virological and immunological characteristics of HIV-infected individuals at the earliest stage of infection Open
View article: Markers of HIV reservoir size and immune activation after treatment in acute HIV infection with and without raltegravir and maraviroc intensification
Markers of HIV reservoir size and immune activation after treatment in acute HIV infection with and without raltegravir and maraviroc intensification Open
Intensification of standard HAART with raltegravir and maraviroc was not associated with either statistically significant reductions of markers of HIV reservoir size in blood and sigmoid colon or markers of immune activation in blood.
View article: Anogenital HIV RNA in Thai men who have sex with men in Bangkok during acute HIV infection and after randomization to standard vs. intensified antiretroviral regimens
Anogenital HIV RNA in Thai men who have sex with men in Bangkok during acute HIV infection and after randomization to standard vs. intensified antiretroviral regimens Open
Introduction HIV transmission risk is highest during acute HIV infection (AHI). We evaluated HIV RNA in the anogenital compartment in men who have sex with men (MSM) during AHI and compared time to undetectable HIV RNA after three‐drug ver…