Raphael Jakubovic
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View article: Surgical Resection With Radiation Treatment Planning of Spinal Tumors
Surgical Resection With Radiation Treatment Planning of Spinal Tumors Open
Background: The clinical paradigm for spinal tumors with epidural involvement is challenging considering the rigid dose tolerance of the spinal cord. One effective approach involves open surgery for tumor resection, follow…
View article: Aluminum and strontium in calcium supplements and antacids: A concern to hemodialysis patients?
Aluminum and strontium in calcium supplements and antacids: A concern to hemodialysis patients? Open
Trace elements, most notably aluminium and strontium, have been noted for their role in the development of secondary bone disorders in haemodialysis patients. Due to the large dosages of calcium required for the maintenance of dialysis pat…
View article: Non-tumor perfusion changes following stereotactic radiosurgery to brain metastases
Non-tumor perfusion changes following stereotactic radiosurgery to brain metastases Open
Purpose: To evaluate early perfusion changes in normal tissue following stereotactic radiosurgery (SRS). Methods: Nineteen patients harboring twenty-two brain metastases treated with SRS were imaged with dynamic susceptibility magnetic res…
View article: Feasibility Of Radiation Dose Planning Guided Surgical Resection In Spinal Tumours
Feasibility Of Radiation Dose Planning Guided Surgical Resection In Spinal Tumours Open
The objective of high dose stereotactic radiotherapy regardless of application is to treat the malignancy while minimizing the radiation dose to the surrounding healthy tissue. In the context of spinal tumours this paradigm is difficult si…
View article: Dosimetric benefits of gantry‐static couch‐motion (GsCM) technique for breast boost radiation therapy: Reduced dose to organs‐at‐risk and improved dosimetric indices
Dosimetric benefits of gantry‐static couch‐motion (GsCM) technique for breast boost radiation therapy: Reduced dose to organs‐at‐risk and improved dosimetric indices Open
To evaluate the clinical feasibility and dosimetric benefits of a novel gantry‐static couch‐motion (GsCM) technique for external beam photon boost treatment of lumpectomy cavity in patients with early‐stage breast cancer in comparison to t…
View article: Quantification of computational geometric congruence in surface-based registration for spinal intra-operative three-dimensional navigation
Quantification of computational geometric congruence in surface-based registration for spinal intra-operative three-dimensional navigation Open
Geometric congruence is most evident at C1 and the subaxial cervical spine, warranting greater vigilance in navigation accuracy verification. At all levels, inclusion of the base of the spinous process in unilateral registration decreases …
View article: Optical Topographic Imaging for Spinal Intraoperative 3-Dimensional Navigation in the Cervical Spine
Optical Topographic Imaging for Spinal Intraoperative 3-Dimensional Navigation in the Cervical Spine Open
Summary of Background Data: Computer-assisted 3-dimensional navigation may guide spinal instrumentation. Optical topographic imaging (OTI) is a novel navigation technique offering comparable accuracy and significantly faster registration w…
View article: Dosimetric Advantages of Volumetric Modulated Arc Therapy Based Coronal Arc Delivery Technique in Brain Stereotactic Radiosurgery: A Feasibility Study
Dosimetric Advantages of Volumetric Modulated Arc Therapy Based Coronal Arc Delivery Technique in Brain Stereotactic Radiosurgery: A Feasibility Study Open
The feasibility of a volumetric modulated arc therapy (VMAT) based coronal arc (cARC) technique for treating a single brain metastasis or lesion proximal to the brainstem or optic chiasm was evaluated. Coplanar (CP) and non-coplanar (NCP) …
View article: Intraoperative Error Propagation in 3-Dimensional Spinal Navigation From Nonsegmental Registration: A Prospective Cadaveric and Clinical Study
Intraoperative Error Propagation in 3-Dimensional Spinal Navigation From Nonsegmental Registration: A Prospective Cadaveric and Clinical Study Open
Study Design: Prospective pre-clinical and clinical cohort study. Objectives: Current spinal navigation systems rely on a dynamic reference frame (DRF) for image-to-patient registration and tool tracking. Working distant to a DRF may gener…
View article: High Speed, High Density Intraoperative 3D Optical Topographical Imaging with Efficient Registration to MRI and CT for Craniospinal Surgical Navigation
High Speed, High Density Intraoperative 3D Optical Topographical Imaging with Efficient Registration to MRI and CT for Craniospinal Surgical Navigation Open
View article: GP.01 Quantification of computational geometric congruence in surface-based registration for spinal intra-operative three-dimensional navigation
GP.01 Quantification of computational geometric congruence in surface-based registration for spinal intra-operative three-dimensional navigation Open
Background : Computer-assisted navigation (CAN) may guide spinal instrumentation, and requires alignment of patient anatomy to imaging. Iterative-Closest-Point algorithms register anatomical and imaging datasets, which may fail in the pres…
View article: High speed, wide velocity dynamic range Doppler optical coherence tomography (Part V): Optimal utilization of multi-beam scanning for Doppler and speckle variance microvascular imaging
High speed, wide velocity dynamic range Doppler optical coherence tomography (Part V): Optimal utilization of multi-beam scanning for Doppler and speckle variance microvascular imaging Open
In this paper, a multi-beam scanning technique is proposed to optimize the microvascular images of human skin obtained with Doppler effect based methods and speckle variance processing. Flow phantom experiments were performed to investigat…
View article: Non Tumor Perfusion Changes Following Stereotactic Radiosurgery to Brain Metastases
Non Tumor Perfusion Changes Following Stereotactic Radiosurgery to Brain Metastases Open
Normal tissue response following SRS can be characterized by dose, tissue, and time specific increases in rCBV and rCBF ratio.