Raphael Johnson
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View article: Formulation and evaluation of topical gels containing Phyllanthus muellerianus leaf extract using various gelling agents
Formulation and evaluation of topical gels containing Phyllanthus muellerianus leaf extract using various gelling agents Open
Introduction: The high expense of current pharmaceuticals used to treat wounds, as well as some of their adverse effects, has spurred the quest for alternatives, particularly those derived from natural sources that have minimum side effect…
View article: Pharmaceutical evaluation of plantain peel pectin as a disintegrant in conventional tablets
Pharmaceutical evaluation of plantain peel pectin as a disintegrant in conventional tablets Open
Plantain peels are a potential source of raw materials for the pharmaceutical industry. In Ghana, most of the pharmaceutical excipients used by local companies are synthetically produced and imported from developed countries. One such exci…
View article: Sweet Potato Peel Pectin's Potential as a Suspending Agent in Pharmaceutical Formulations: The Effect of Extraction Technique
Sweet Potato Peel Pectin's Potential as a Suspending Agent in Pharmaceutical Formulations: The Effect of Extraction Technique Open
Introduction: Sweet potato (Ipomoea batatas L. Lam) represents an essential underutilised crop globally. The ubiquitous hydrocolloid, pectin, with versatile pharmaceutical and cosmetic applications has been reported to be abundant in the p…
View article: Extraction and Comparative Assessment of the Physicochemical Properties of Pectin From Four Fruit Wastes in Ghana
Extraction and Comparative Assessment of the Physicochemical Properties of Pectin From Four Fruit Wastes in Ghana Open
Substantial amounts of waste and by‐products are generated annually from the fruit processing industry – an issue with detrimental environmental, socioeconomic and health impacts. Concerted efforts are currently geared towards curtailing t…
View article: Evaluation of the Physicochemical and Micromeritic Properties of Exudate Gum of Cussonia arborea Stem Bark in Conventional Tablet Formulation
Evaluation of the Physicochemical and Micromeritic Properties of Exudate Gum of Cussonia arborea Stem Bark in Conventional Tablet Formulation Open
Pharmaceutical excipients are classified based on the function(s) in the processing and/or finished product. However, functionality evaluations, procedures, and related acceptance criteria for excipients tend to depend on the dosage form, …
View article: Investigating the Presence of Falsified and Poor-Quality Fixed-Dose Combination Artemether-Lumefantrine Pharmaceutical Dosage Forms in Kumasi, Ghana
Investigating the Presence of Falsified and Poor-Quality Fixed-Dose Combination Artemether-Lumefantrine Pharmaceutical Dosage Forms in Kumasi, Ghana Open
Artemether-lumefantrine (AL) is a highly effective and commonly used Artemisinin-based Combination Therapy (ACT) for treating uncomplicated malaria caused by Plasmodium falciparum, including drug-resistant strains. However, ineffective reg…
View article: Effect of Ripening and Extraction Method on the Physicochemical Properties of Pectin Extracted from Peels of Apem and Apantu Plantain Cultivars in Ghana
Effect of Ripening and Extraction Method on the Physicochemical Properties of Pectin Extracted from Peels of Apem and Apantu Plantain Cultivars in Ghana Open
Fruit waste has emerged as a significant environmental issue in recent years, adding to the global burden. In Ghana, the extensive use of plantains at various stages of ripeness results in substantial waste during each processing stage, le…
View article: Development of the RP-HPLC Method for Simultaneous Determination and Quantification of Artemether and Lumefantrine in Fixed-Dose Combination Pharmaceutical Dosage Forms
Development of the RP-HPLC Method for Simultaneous Determination and Quantification of Artemether and Lumefantrine in Fixed-Dose Combination Pharmaceutical Dosage Forms Open
Developing countries face enormous challenges with substandard and falsified antimalarial drugs. One specific issue is the lack of a simple, cost-effective, and robust HPLC method to simultaneously determine and quantify the active pharmac…
View article: Biogenic Waste from Two Varieties of Plantain in Ghana Contain Pectin with Potential Binding Properties in Conventional Tablets
Biogenic Waste from Two Varieties of Plantain in Ghana Contain Pectin with Potential Binding Properties in Conventional Tablets Open
Pharmaceutical formulations have traditionally relied on plants and their derivatives for various APIs and excipients. In Ghana, the widespread utilization of plantains, irrespective of their ripeness, generates significant waste at every …
View article: Investigation of the binding properties of purified Pentadesma butyracea gum: Anatural alternative to a synthetic polymer
Investigation of the binding properties of purified Pentadesma butyracea gum: Anatural alternative to a synthetic polymer Open
The focus of most pharmaceutical research in recent times has been the use of natural products like gums as pharmaceutical excipients because they are safer, economical and readily available. This study aimed to investigate the applicabili…
View article: Pharmaceutical Assessment of the Impact of the Method of Extraction on the Suitability of Pectin from Plantain (Musa paradisiaca) Peels as a Suspending Agent in Oral Liquid Formulations
Pharmaceutical Assessment of the Impact of the Method of Extraction on the Suitability of Pectin from Plantain (Musa paradisiaca) Peels as a Suspending Agent in Oral Liquid Formulations Open
Natural polymers such as pectin have gained increased utilization in pharmaceutical and biotechnology sectors because they are affordable, easily accessible, nontoxic, and chemically modifiable, with the potential to be biodegradable and b…
View article: The Consumption of Energy Drink and Its Potential Effect on Sleep Patterns: A Case Study in the Kumasi Metropolis
The Consumption of Energy Drink and Its Potential Effect on Sleep Patterns: A Case Study in the Kumasi Metropolis Open
Background: The availability of energy drinks on the global market result from intensive marketing campaigns in the media. The purpose of this study was to evaluate the consumption of energy drink and its potential effect on sleep patterns…
View article: Physicochemical and Microbiological Characteristics of Stem Bark Exudate Gum of Cordia millenii Tree in Conventional Release Tablets
Physicochemical and Microbiological Characteristics of Stem Bark Exudate Gum of Cordia millenii Tree in Conventional Release Tablets Open
The development of a raw material into an acceptable pharmaceutical excipient involves evaluation of the physicochemical and formulation properties of the potential raw material. Results from these evaluations may serve as a guide to subse…
View article: The Impact of the Extraction Method on Allanblackia floribunda Butter’s Physicochemical Properties as a Possible Pharmaceutical Excipient
The Impact of the Extraction Method on Allanblackia floribunda Butter’s Physicochemical Properties as a Possible Pharmaceutical Excipient Open
The extraction method of edible Allanblackia floribunda seed butter is crucial for preserving its constituents. The objective of the present study was to investigate the effects the extraction methods have on the physicochemical properties…
View article: Formulation and Evaluation of Herbal‐Based Antiacne Gel Preparations
Formulation and Evaluation of Herbal‐Based Antiacne Gel Preparations Open
Acne vulgaris is an inflammatory skin condition that affects virtually everyone at some point. Papules, comedones, pustules, scarring, and nodules are standard features of the disease and can have a detrimental social and psychological imp…
View article: Pharmaceutical Assessment of Melia azedarach Gum as a Binder and Disintegrant in Immediate-Release Tablets
Pharmaceutical Assessment of Melia azedarach Gum as a Binder and Disintegrant in Immediate-Release Tablets Open
Excipients are components other than active ingredients that are added to pharmaceutical formulations. Naturally sourced excipients are gradually gaining preeminence over synthetically sourced excipients due to local availability and conti…
View article: Pharmaceutical Assessment of Watermelon Rind Pectin as a Suspending Agent in Oral Liquid Dosage Forms
Pharmaceutical Assessment of Watermelon Rind Pectin as a Suspending Agent in Oral Liquid Dosage Forms Open
Pectin is a high molecular weight polymer which is present in virtually all plants where it contributes to the cell structure. Pectin is a high valuable food ingredient widely used as a gelling agent and thickening agent with limited use i…
View article: Formulation of Suppositories of Alum Produced from Bauxite Waste in Ghana for the Treatment of Hemorrhoid
Formulation of Suppositories of Alum Produced from Bauxite Waste in Ghana for the Treatment of Hemorrhoid Open
The study sought to formulate and evaluate suppositories using a locally produced brand of alum (Aw) obtained from bauxite waste generated at Awaso bauxite mine in the Western-North region of Ghana, for use in the treatment of hemorrhoids.…
View article: Comparison of the physicochemical properties and in vivo bioavailability of generic and innovator artemether-lumefantrin tablets in Kumasi, Ghana
Comparison of the physicochemical properties and in vivo bioavailability of generic and innovator artemether-lumefantrin tablets in Kumasi, Ghana Open
Context: Malarial remains a leading course of death in developing countries. Current treatment protocol involves the use of artemisinin-based combination therapy. In endemic areas, cost of treatment is a concern hence generic prescription …
View article: Target Nanoparticles for Therapy - SANS and DLS of Drug Carrier Liposomes and Polymer Nanoparticles
Target Nanoparticles for Therapy - SANS and DLS of Drug Carrier Liposomes and Polymer Nanoparticles Open
T arget Nano-Pharmaceutics shall improve therapy and diagnosis of severe diseases, e.g. cancer, by individual targeting of drug-loaded nano-pharmaceuticals towards cancer cells, and drug uptake receptors in other diseases. Specific ligands…