R. Lecomte
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View article: Synovial Biomarkers C-Reactive Protein and Calprotectin for Diagnosing Chronic Periprosthetic Joint Infection: A Prospective Multicenter Evaluation
Synovial Biomarkers C-Reactive Protein and Calprotectin for Diagnosing Chronic Periprosthetic Joint Infection: A Prospective Multicenter Evaluation Open
The present study demonstrates that synovial calprotectin and synovial CRP assays have excellent accuracy for the diagnosis of PJI. These findings suggest that these two synovial biomarkers should be incorporated into a new decision-making…
View article: Antibiotic therapy and prophylaxis of infective endocarditis – A SPILF-AEPEI position statement on the ESC 2023 guidelines
Antibiotic therapy and prophylaxis of infective endocarditis – A SPILF-AEPEI position statement on the ESC 2023 guidelines Open
International audience
View article: Outcomes of <i>Enterococcus faecalis</i> infective endocarditis according to MIC of amoxicillin: a multicentric study
Outcomes of <i>Enterococcus faecalis</i> infective endocarditis according to MIC of amoxicillin: a multicentric study Open
Background The incidence of Enterococcus faecalis infective endocarditis is increasing over time. Data on the impact of minimum inhibitory concentration (MIC) of amoxicillin on treatment outcomes are scarce. The objective of this study was…
View article: Efficacy and safety of co-trimoxazole in device-related bone and joint infections: a CRIOGO multicentre case–control study
Efficacy and safety of co-trimoxazole in device-related bone and joint infections: a CRIOGO multicentre case–control study Open
Objectives Co-trimoxazole could be an alternative antibiotic to treat device-related bone and joint infection (BJI) but there are few published data about its efficacy and safety in this complex scenario to treat infection. The objective w…
View article: Dalbavancin-resistant <i>Staphylococcus epidermidis in vivo</i> selection following a prosthetic joint infection: phenotypic and genomic characterization
Dalbavancin-resistant <i>Staphylococcus epidermidis in vivo</i> selection following a prosthetic joint infection: phenotypic and genomic characterization Open
Background Dalbavancin is a lipoglycopeptide antibiotic with a wide spectrum of activity against Gram-positive bacteria, including MDR isolates. Its pharmacokinetic properties and administration patterns could be useful for the treatment o…
View article: <i>Staphylococcus succinus</i> Infective Endocarditis, France
<i>Staphylococcus succinus</i> Infective Endocarditis, France Open
Infective endocarditis is a rare condition in humans and is associated with high illness and death rates. We describe a case of infective endocarditis caused by Staphylococcus succinus bacteria in France. We used several techniques for sus…
View article: Effect of Swine Glyco-humanized Polyclonal Neutralizing Antibody on Survival and Respiratory Failure in Patients Hospitalized With Severe COVID-19: A Randomized, Placebo-Controlled Trial
Effect of Swine Glyco-humanized Polyclonal Neutralizing Antibody on Survival and Respiratory Failure in Patients Hospitalized With Severe COVID-19: A Randomized, Placebo-Controlled Trial Open
Background We evaluated the safety and efficacy of XAV-19, an antispike glyco-humanized swine polyclonal neutralizing antibody in patients hospitalized with severe coronavirus disease 2019 (COVID-19). Methods This phase 2b clinical trial e…
View article: The Brief Case: A Mixed <i>Cutibacterium</i> Species Positive Valve Culture Hiding a <i>Bartonella</i> Infective Endocarditis
The Brief Case: A Mixed <i>Cutibacterium</i> Species Positive Valve Culture Hiding a <i>Bartonella</i> Infective Endocarditis Open
International audience
View article: A case report of unilateral cerebral vasculitis in adults: keep in mind Lyme neuroborreliosis
A case report of unilateral cerebral vasculitis in adults: keep in mind Lyme neuroborreliosis Open
Background Lyme neuroborreliosis (LNB), due to infection of the nervous system by the spirochete Borrelia burgdorferi , occurs in 15% of Lyme disease cases. However, neurovascular involvement is uncommon, especially recurrent stroke relate…
View article: Xpert MTB/RIF Ultra Trace Results: Decision Support for the Treatment of Extrapulmonary Tuberculosis in Low TB Burden Countries
Xpert MTB/RIF Ultra Trace Results: Decision Support for the Treatment of Extrapulmonary Tuberculosis in Low TB Burden Countries Open
Objectives. Extrapulmonary tuberculosis (EPTB) can be difficult to diagnose, especially in severe forms. The Xpert MTB/RIF Ultra test introduced an additional category called trace to reference very small amounts of Mycobacterium tuberculo…
View article: Development and validation of a dosing nomogram for continuous infusion cloxacillin in infective endocarditis
Development and validation of a dosing nomogram for continuous infusion cloxacillin in infective endocarditis Open
Background Cloxacillin is the first-line treatment for methicillin-susceptible staphylococcal infective endocarditis (IE). The recommended dose is 12 g per day regardless of the patient characteristics, despite the importance of renal func…
View article: Encephalitis in travellers: a prospective multicentre study
Encephalitis in travellers: a prospective multicentre study Open
Background As the epidemiology of encephalitis varies from one country to another, international travel may be an important clue for the diagnostic workout of this puzzling disease. Methods We performed an ancillary study using the ENCEIF …
View article: 18F-FDG-based radiomics and machine learning: a useful help for aortic prosthetic valve infective endocarditis diagnosis?
18F-FDG-based radiomics and machine learning: a useful help for aortic prosthetic valve infective endocarditis diagnosis? Open
Introduction FDG PET/CT allows for a better sensitivity in the prosthetic valve endocartitis (PVE) diagnostic when integrated to ESC 2015 criteria, but visual image analysis results in a weaker specificity and is subject to an inter-observ…
View article: Evaluation of the safety and efficacy of XAV-19 in patients with COVID-19-induced moderate pneumonia: study protocol for a randomized, double-blinded, placebo-controlled phase 2 (2a and 2b) trial
Evaluation of the safety and efficacy of XAV-19 in patients with COVID-19-induced moderate pneumonia: study protocol for a randomized, double-blinded, placebo-controlled phase 2 (2a and 2b) trial Open
Background Early inhibition of entry and replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a very promising therapeutic approach. Polyclonal neutralizing antibodies offers many advantages such as providing …
View article: Is Rifampin Use Associated With Better Outcome in Staphylococcal Prosthetic Valve Endocarditis? A Multicenter Retrospective Study
Is Rifampin Use Associated With Better Outcome in Staphylococcal Prosthetic Valve Endocarditis? A Multicenter Retrospective Study Open
Background International guidelines recommend rifampin-based combinations for staphylococcal prosthetic valve endocarditis (PVE). However, no robust clinical data support this recommendation, and rifampin tolerability is an issue. We aimed…
View article: Lopinavir pharmacokinetics in COVID-19 patients
Lopinavir pharmacokinetics in COVID-19 patients Open
International audience
View article: Long-term Outcome of Patients With Nonoperated Prosthetic Valve Infective Endocarditis: Is Relapse the Main Issue?
Long-term Outcome of Patients With Nonoperated Prosthetic Valve Infective Endocarditis: Is Relapse the Main Issue? Open
In nonoperated prosthetic valve endocarditis (PVE), long-term outcome is largely unknown. We report the follow-up of 129 nonoperated patients with PVE alive at discharge. At 1 year, the mortality rate was 24%; relapses and reinfection were…
View article: Outcome and prognostic factors of Pneumocystis jirovecii pneumonia in immunocompromised adults: a prospective observational study
Outcome and prognostic factors of Pneumocystis jirovecii pneumonia in immunocompromised adults: a prospective observational study Open
Background Pneumocystis jirovecii pneumonia (PJP) remains a severe disease associated with high rates of invasive mechanical ventilation (MV) and mortality. The objectives of this study were to assess early risk factors for severe PJP and …