Raphael Lieberherr
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View article: An out-of-hours cell culture autopilot proof of concept based on a modular architecture using the SiLA2 open standard
An out-of-hours cell culture autopilot proof of concept based on a modular architecture using the SiLA2 open standard Open
There has been much talk and substantial progress in automated and flexible smart lab concepts in biopharma R&D. This is acknowledged to be important in enabling the acceleration of innovation and digitization of R&D operations. However, m…
View article: NF-κB drives epithelial-mesenchymal mechanisms of lung fibrosis in a translational lung cell model
NF-κB drives epithelial-mesenchymal mechanisms of lung fibrosis in a translational lung cell model Open
In the progression phase of idiopathic pulmonary fibrosis (IPF), the normal alveolar structure of the lung is lost and replaced by remodeled fibrotic tissue and by bronchiolized cystic airspaces. Although these are characteristic features …
View article: Novel high–throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors
Novel high–throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors Open
Pathological features of pulmonary fibrosis include accumulation of myofibroblasts and increased extracellular matrix (ECM) deposition in lung tissue. Contractile α-smooth muscle actin (α-SMA)-expressing myofibroblasts that produce and sec…