Raphaël Pineau
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View article: P01.12.B COMBINED EFFECTS OF IRE1 INHIBITION AND TEMOZOLOMIDE IN GLIOBLASTOMA MOUSE MODELS: POTENTIAL MECHANISMS OF ACTION
P01.12.B COMBINED EFFECTS OF IRE1 INHIBITION AND TEMOZOLOMIDE IN GLIOBLASTOMA MOUSE MODELS: POTENTIAL MECHANISMS OF ACTION Open
BACKGROUND Glioblastoma (GB), the most frequent and aggressive primary brain tumor in adult, remains an incurable disease. New efficient therapy is required to improve patient care. We showed that coupling temozolomide (TMZ) treatment with…
View article: P01.16.B MULTIOMICS ANALYSIS UNVEILS THE ROLE OF EMX2 EXPRESSION IN ATTENUATION OF EGFR EXPRESSION IN GLIOBLASTOMA
P01.16.B MULTIOMICS ANALYSIS UNVEILS THE ROLE OF EMX2 EXPRESSION IN ATTENUATION OF EGFR EXPRESSION IN GLIOBLASTOMA Open
BACKGROUND Glioblastoma (GB), the most frequent and aggressive primary brain tumor in adult, remains an incurable disease. Better knowledge of this disease is important to design novel therapies to improve patient care. The transcription f…
View article: Junctional adhesion molecule C limits glioblastoma stem-like cell invasion by regulating integrin adhesion at the endothelial interface
Junctional adhesion molecule C limits glioblastoma stem-like cell invasion by regulating integrin adhesion at the endothelial interface Open
While locating in different microenvironments, glioblastoma stem-like cells (GSCs) receive maintenance signals and information to exploit neurovascular tracts. Although the cell adhesion mechanisms to blood vessels have been explored, the …
View article: DOP076 Translational and preclinical study validating anterior gradient 2 as a novel epithelial therapeutic target in Inflammatory Bowel Disease (IBD) involved in inflammation, fibrosis, and intestinal barrier integrity
DOP076 Translational and preclinical study validating anterior gradient 2 as a novel epithelial therapeutic target in Inflammatory Bowel Disease (IBD) involved in inflammation, fibrosis, and intestinal barrier integrity Open
Background Anterior Gradient 2 (AGR2) is an endoplasmic reticulum (ER) resident protein involved in protein folding, predominantly expressed in mucin-secreting epithelial cells. Under stress, AGR2 is secreted into the extracellular milieu …
View article: Protocol to generate two distinct standard-of-care murine glioblastoma models for evaluating novel combination therapies
Protocol to generate two distinct standard-of-care murine glioblastoma models for evaluating novel combination therapies Open
In cancer research, murine models play a crucial role as highly valuable preclinical tools. Here, we present a protocol to generate a murine model of glioblastoma through the direct intracranial injection of tumor cells. We describe steps …
View article: Afatinib or Bevacizumab in combination with Osimertinib efficiently control tumor development in orthotopic murine models of non-small lung cancer
Afatinib or Bevacizumab in combination with Osimertinib efficiently control tumor development in orthotopic murine models of non-small lung cancer Open
Lung cancer is one of the most common and deadliest cancers. Preclinical models are essential to study new therapies and combinations taking tumor genetics into account. We have established cell lines expressing the luciferase gene from li…
View article: IRE1 endoribonuclease signaling promotes myeloid cell infiltration in glioblastoma
IRE1 endoribonuclease signaling promotes myeloid cell infiltration in glioblastoma Open
Background Intrinsic or environmental stresses trigger the accumulation of improperly folded proteins in the endoplasmic reticulum (ER), leading to ER stress. To cope with this, cells have evolved an adaptive mechanism named the unfolded p…
View article: Supplementary Materials and Methods, Supplementary Figures 1-7, Supplementary Tables 1-2 from CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma
Supplementary Materials and Methods, Supplementary Figures 1-7, Supplementary Tables 1-2 from CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma Open
Figure S1: CD90 mRNA expression on NCI and glioma cell lines, glioma and GBM specimens; Figure S2: CD90 mRNA and protein are expressed on all GBM cells; Figure S3: Expression of adhesion/migration genes in CD90low and CD90high RNS cell lin…
View article: Data from CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma
Data from CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma Open
Purpose: CD90 (Thy-1) is a glycophosphatidylinositol-anchored glycoprotein considered as a surrogate marker for a variety of stem cells, including glioblastoma (GBM) stem cells (GSC). However, the molecular and cellular functions of CD90 r…
View article: Supplementary Materials and Methods, Supplementary Figures 1-7, Supplementary Tables 1-2 from CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma
Supplementary Materials and Methods, Supplementary Figures 1-7, Supplementary Tables 1-2 from CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma Open
Figure S1: CD90 mRNA expression on NCI and glioma cell lines, glioma and GBM specimens; Figure S2: CD90 mRNA and protein are expressed on all GBM cells; Figure S3: Expression of adhesion/migration genes in CD90low and CD90high RNS cell lin…
View article: Data from CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma
Data from CD90 Expression Controls Migration and Predicts Dasatinib Response in Glioblastoma Open
Purpose: CD90 (Thy-1) is a glycophosphatidylinositol-anchored glycoprotein considered as a surrogate marker for a variety of stem cells, including glioblastoma (GBM) stem cells (GSC). However, the molecular and cellular functions of CD90 r…
View article: Fig.S1 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer
Fig.S1 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer Open
Expression Analysis of CXCL4L1 in human pancreatic tissue
View article: Data from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer
Data from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer Open
The CXCL4 paralog CXCL4L1 is a less studied chemokine that has been suggested to exert an antiangiogenic function. However, CXCL4L1 is also expressed in patient tumors, tumor cell lines, and murine xenografts, prompting a more detailed ana…
View article: Fig.S7 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer
Fig.S7 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer Open
Characterization of PECAM-1 expression in pancreatic tumours
View article: Supplemental Material and Methods from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer
Supplemental Material and Methods from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer Open
Supplemental Material and Method section
View article: Fig.S6 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer
Fig.S6 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer Open
In vivo characterization of the MabL1 antibody
View article: Data from Posttranscriptional Regulation of <i>PER1</i> Underlies the Oncogenic Function of IREα
Data from Posttranscriptional Regulation of <i>PER1</i> Underlies the Oncogenic Function of IREα Open
Growing evidence supports a role for the unfolded protein response (UPR) in carcinogenesis; however, the precise molecular mechanisms underlying this phenomenon remain elusive. Herein, we identified the circadian clock PER1 mRNA as a novel…
View article: Data from IRE1 Signaling Is Essential for Ischemia-Induced Vascular Endothelial Growth Factor-A Expression and Contributes to Angiogenesis and Tumor Growth <i>In vivo</i>
Data from IRE1 Signaling Is Essential for Ischemia-Induced Vascular Endothelial Growth Factor-A Expression and Contributes to Angiogenesis and Tumor Growth <i>In vivo</i> Open
In solid tumors, cancer cells subjected to ischemic conditions trigger distinct signaling pathways contributing to angiogenic stimulation and tumor development. Characteristic features of tumor ischemia include hypoxia and glucose deprivat…
View article: Fig.S7 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer
Fig.S7 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer Open
Characterization of PECAM-1 expression in pancreatic tumours
View article: Supplementary Tables 1 - 5, Figures 1 - 11 from Posttranscriptional Regulation of <i>PER1</i> Underlies the Oncogenic Function of IREα
Supplementary Tables 1 - 5, Figures 1 - 11 from Posttranscriptional Regulation of <i>PER1</i> Underlies the Oncogenic Function of IREα Open
PDF file - 809K, Table S1 List of genes deregulated in IRE1_DN cells. Table S2 Potential IRE1 cleavage sites on PER1 mRNA. Table S3 Characteristics of human glioma biopsies used in this study. Table S4 Primer Pairs used for PCR and qPCR st…
View article: Fig.S4 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer
Fig.S4 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer Open
CXCR3 gene expression analysis
View article: Fig.S6 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer
Fig.S6 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer Open
In vivo characterization of the MabL1 antibody
View article: Fig.S5 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer
Fig.S5 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer Open
Effect of CXCL4L1 and CXCL4 on apoptosis in pancreatic adenocarcinoma cells and endothelial cells
View article: Supplemental Material and Methods from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer
Supplemental Material and Methods from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer Open
Supplemental Material and Method section
View article: Data from Posttranscriptional Regulation of <i>PER1</i> Underlies the Oncogenic Function of IREα
Data from Posttranscriptional Regulation of <i>PER1</i> Underlies the Oncogenic Function of IREα Open
Growing evidence supports a role for the unfolded protein response (UPR) in carcinogenesis; however, the precise molecular mechanisms underlying this phenomenon remain elusive. Herein, we identified the circadian clock PER1 mRNA as a novel…