Explanipedia

Magnitude and Mechanism of Phrenic Long-term Facilitation Shift Between Daily Rest Versus Active Phase Open

Alexandria B. Marciante, Yasin B. Seven, Mia N. Kelly, Raphael R. Perim, Gordon S. Mitchell · 2023

Plasticity is a fundamental property of the neural system controlling breathing. One key example of respiratory motor plasticity is phrenic long-term facilitation (pLTF), a persistent increase in phrenic nerve activity elicited by acute in…

Daily fluctuations in spinal adenosine determine mechanisms of respiratory motor plasticity Open

Alexandria B. Marciante, Yasin B. Seven, Mia N. Kelly, Raphael R. Perim, Gordon S. Mitchell · 2022

Plasticity is a fundamental property of the neuromotor system controlling breathing. One key example of respiratory motor plasticity is phrenic long-term facilitation (pLTF), a persistent increase in phrenic nerve activity after exposure t…

Daily acute intermittent hypoxia enhances phrenic motor output and stimulus-evoked phrenic responses in rats Open

Raphael R. Perim, Michael D. Sunshine, Joseph F. Welch, Juliet V. Santiago, Ashley Holland , et al. · 2021

Two weeks of daily acute intermittent hypoxia (dAIH) preconditioning enhanced stimulus-evoked phrenic responses to lateral funiculus stimulation (targeting respiratory bulbospinal projection to phrenic motor neurons). Furthermore, dAIH pre…

Cervical spinal injury compromises caudal spinal tissue oxygenation and undermines acute intermittent hypoxia-induced phrenic long-term facilitation Open

Raphael R. Perim, Elisa J. Gonzalez‐Rothi, Gordon S. Mitchell · 2021

Baseline Arterial CO2 Pressure Regulates Acute Intermittent Hypoxia-Induced Phrenic Long-Term Facilitation in Rats Open

Raphael R. Perim, Mohamed El-Chami, Elisa J. Gonzalez‐Rothi, Gordon S. Mitchell · 2021

Moderate acute intermittent hypoxia (mAIH) elicits a progressive increase in phrenic motor output lasting hours post-mAIH, a form of respiratory motor plasticity known as phrenic long-term facilitation (pLTF). mAIH-induced pLTF is initiate…

Effect of acute intermittent hypoxia on cortico-diaphragmatic conduction in healthy humans Open

Joseph F. Welch, Raphael R. Perim, Patrick J. Argento, Tommy W. Sutor, Alicia K. Vose , et al. · 2021

Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity Open

Arash Tadjalli, Yasin B. Seven, Raphael R. Perim, Gordon S. Mitchell · 2021

Hypoxia-induced hypotension elicits adenosine-dependent phrenic long-term facilitation after carotid denervation Open

Raphael R. Perim, Paul Kubilis, Yasin B. Seven, Gordon S. Mitchell · 2020

Synergy between Acute Intermittent Hypoxia and Task-Specific Training Open

Joseph F. Welch, Tommy W. Sutor, Alicia K. Vose, Raphael R. Perim, Emily J. Fox , et al. · 2020

Acute intermittent hypoxia (AIH) and task-specific training (TST) synergistically improve motor function after spinal cord injury; however, mechanisms underlying this synergistic relation are unknown. We propose a hypothetical working mode…

Spinal AMP kinase activity differentially regulates phrenic motor plasticity Open

Raphael R. Perim, Daryl P. Fields, Gordon S. Mitchell · 2020

Acute intermittent hypoxia (AIH) elicits phrenic motor plasticity via multiple distinct cellular mechanisms. With moderate AIH, phrenic motor facilitation (pMF) requires G q protein-coupled serotonin type 2 receptor activation, ERK MAP kin…

SPARC bilateral terminal phrenic neurophysiology preparation with moderate acute intermittent hypoxia v1 Open

Elisa J. Gonzalez‐Rothi, Arash Tadjalli, Raphael R. Perim, Gordon S. Mitchell · 2019

Protocol for conducting bilateral phrenic neurograms in anesthetized, paralyzed, vagotomized and mechanically ventilated rats - moderate acute intermittent hypoxia-induced phrenic long-term facilitation protocol

Circulatory control of phrenic motor plasticity Open

Raphael R. Perim, Gordon S. Mitchell · 2019

Protein kinase Cδ constrains the S‐pathway to phrenic motor facilitation elicited by spinal 5‐HT7 receptors or severe acute intermittent hypoxia Open

Raphael R. Perim, Daryl P. Fields, Gordon S. Mitchell · 2018

Key points Concurrent 5‐HT 2A (Q pathway) and 5‐HT 7 (S pathway) serotonin receptor activation cancels phrenic motor facilitation due to mutual cross‐talk inhibition. Spinal protein kinase Cδ (PKCδ) or protein kinase A inhibition restores …

Phrenic motor neuron adenosine 2A receptors elicit phrenic motor facilitation Open

Yasin B. Seven, Raphael R. Perim, Orinda R. Hobson, Alec K. Simon, Arash Tadjalli , et al. · 2018

Key points Although adenosine 2A (A 2A ) receptor activation triggers specific cell signalling cascades, the ensuing physiological outcomes depend on the specific cell type expressing these receptors. Cervical spinal adenosine 2A (A 2A ) r…

Cross-talk inhibition between 5-HT2B and 5-HT7 receptors in phrenic motor facilitation via NADPH oxidase and PKA Open

Raphael R. Perim, Daryl P. Fields, Gordon S. Mitchell · 2018

Intermittent spinal serotonin receptor activation elicits phrenic motor facilitation (pMF), a form of spinal respiratory motor plasticity. Episodic activation of either serotonin type 2 (5-HT 2 ) or type 7 (5-HT 7 ) receptors elicits pMF, …

Previous exposure to chronic intermittent hypoxia blunts the development of one‐kidney, one‐clip hypertension in rats Open

Raphael R. Perim, Mateus R. Amorim, The Late Leni G. H. Bonagamba, Benedito H. Machado · 2018

New Findings What is the central question of this study? Chronic intermittent hypoxia (CIH) and one‐kidney, one‐clip experimental models lead to sympathetic overactivity and hypertension. The present study explored the impact of previous e…

Efeitos do pré-condicionamento à hipóxia sobre as alterações cardiovasculares e respiratórias promovidas por diferentes modelos de hipertensão experimental em ratos Open

Raphael R. Perim · 2016

\n Ratos jovens submetidos à hipóxia crônica intermitente (HCI) por um período de 10 dias apresentam hipertensão arterial e alterações no padrão de acoplamento das atividades simpática e respiratória. A exposição à HCI promove aumento da a…

Cardiovascular and respiratory outcome of preconditioned rats submitted to chronic intermittent hypoxia Open

Raphael R. Perim, Leni G. H. Bonagamba, Benedito H. Machado · 2015

New Findings What is the central question of this study? What are the effects of hypoxic preconditioning upon the cardiovascular and respiratory responses to subsequent episodes of chronic intermittent hypoxia? What is the main finding and…

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