Raphaël Roduit
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View article: Autophagy Impairment in Retinal Ganglion Cells Following Hypoglycemia in Mice
Autophagy Impairment in Retinal Ganglion Cells Following Hypoglycemia in Mice Open
(1) Background: Diabetic retinopathy (DR), caused by hypo- and hyperglycaemia, is the leading cause of blindness. Hypoglycemia induces endoplasmic reticulum stress and retinal cell death in mice, and low-glucose conditions induce macroauto…
View article: CNGB3 Missense Variant Causes Recessive Achromatopsia in Original Braunvieh Cattle
CNGB3 Missense Variant Causes Recessive Achromatopsia in Original Braunvieh Cattle Open
Sporadic occurrence of inherited eye disorders has been reported in cattle but so far pathogenic variants were found only for rare forms of cataract but not for retinopathies. The aim of this study was to characterize the phenotype and the…
View article: GSH-Independent Induction of ER Stress during Hypoglycaemia in the Retinal Cells of Mice
GSH-Independent Induction of ER Stress during Hypoglycaemia in the Retinal Cells of Mice Open
Glucose is one of the most important metabolic substrates of the retina, and glycaemic imbalances can lead to serious side effects, including retinopathy. We previously showed that hypoglycaemia induces retinal cell death in mice, as well …
View article: CNGB3 missense variant causes recessive day-blindness (achromatopsia) in Original Braunvieh cattle
CNGB3 missense variant causes recessive day-blindness (achromatopsia) in Original Braunvieh cattle Open
View article: Molecular Biomarkers of Neovascular Age-Related Macular Degeneration With Incomplete Response to Anti-Vascular Endothelial Growth Factor Treatment
Molecular Biomarkers of Neovascular Age-Related Macular Degeneration With Incomplete Response to Anti-Vascular Endothelial Growth Factor Treatment Open
The standard treatment for neovascular age-related macular degeneration (nAMD) consists of intravitreal anti-vascular endothelial growth factors (VEGF). However, for some patients, even maximal anti-VEGF treatment does not entirely suppres…
View article: Role Of Er Stress In Hypoglyaemia-Induced Mouse Retina Cell Death
Role Of Er Stress In Hypoglyaemia-Induced Mouse Retina Cell Death Open
View article: Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration
Loss of Extracellular Signal-Regulated Kinase 1/2 in the Retinal Pigment Epithelium Leads to RPE65 Decrease and Retinal Degeneration Open
Recent work suggested that the activity of extracellular signal-regulated kinase 1/2 (ERK1/2) is increased in the retinal pigment epithelium (RPE) of age-related macular degeneration (ARMD) patients and therefore could be an attractive the…
View article: Bis-Retinoid A2E Induces an Increase of Basic Fibroblast Growth Factor via Inhibition of Extracellular Signal-Regulated Kinases 1/2 Pathway in Retinal Pigment Epithelium Cells and Facilitates Phagocytosis.2
Bis-Retinoid A2E Induces an Increase of Basic Fibroblast Growth Factor via Inhibition of Extracellular Signal-Regulated Kinases 1/2 Pathway in Retinal Pigment Epithelium Cells and Facilitates Phagocytosis.2 Open
Age-related macular degeneration (ARMD) is the leading cause of vision loss in developed countries. Hallmarks of the disease are well known; indeed, this pathology is characterized by lipofuscin accumulation, is principally composed of lip…
View article: RPE cell specific loss of ERK1/2 leads to retinal degeneration.
RPE cell specific loss of ERK1/2 leads to retinal degeneration. Open
View article: Biological Characterization of Gene Response to Insulin-Induced Hypoglycemia in Mouse Retina
Biological Characterization of Gene Response to Insulin-Induced Hypoglycemia in Mouse Retina Open
Glucose is the most important metabolic substrate of the retina and maintenance of normoglycemia is an essential challenge for diabetic patients. Chronic, exaggerated, glycemic excursions could lead to cardiovascular diseases, nephropathy,…
View article: Specific ATG5 or ATG7 inhibition induces cell death and caspase 3 activity.
Specific ATG5 or ATG7 inhibition induces cell death and caspase 3 activity. Open
661W cells were cultured as mentioned in material & methods. A) Each clonal cell colony was cultured at 1 mM (g, h, i) or 25 mM (j, k, l) glucose for 48 h prior cell death analysis by TUNEL assay. White arrows show TUNEL positive dy…
View article: Specific inhibition of ATG5 and ATG7 decrease low glucose-induced LC3-II accumulation.
Specific inhibition of ATG5 and ATG7 decrease low glucose-induced LC3-II accumulation. Open
Lentiviruses expressing specific shRNA were used to decrease the expression of ATG5 and ATG7 as described in material & methods, then each clonal cell colony was treated and cultured as mentioned in material & methods. A) Representa…