Raphaël Thuret
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View article: Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe
Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe Open
Summary In brief The mechanisms regulating the signaling pathways involved in angiogenesis are not fully known. Ristori et al. show that Lunatic Fringe (LFng) mediates the crosstalk between Bone Morphogenic Protein 9 (Bmp9) and Notch signa…
View article: Foxm1 regulates neural progenitor fate during spinal cord regeneration
Foxm1 regulates neural progenitor fate during spinal cord regeneration Open
Xenopus tadpoles have the ability to regenerate their tails upon amputation. Although some of the molecular and cellular mechanisms that globally regulate tail regeneration have been characterised, tissue-specific response to injury remain…
View article: Active perception during angiogenesis: filopodia speed up Notch selection of tip cells <i> in silico <i>and</i> in vivo </i>
Active perception during angiogenesis: filopodia speed up Notch selection of tip cells <i> in silico <i>and</i> in vivo </i> Open
How do cells make efficient collective decisions during tissue morphogenesis? Humans and other organisms use feedback between movement and sensing known as ‘sensorimotor coordination’ or ‘active perception’ to inform behaviour, but active …
View article: Active Perception during Angiogenesis: Filopodia speed up Notch selection of tip cells<i>in silico</i>and<i>in vivo</i>
Active Perception during Angiogenesis: Filopodia speed up Notch selection of tip cells<i>in silico</i>and<i>in vivo</i> Open
How do cells make efficient collective decisions during tissue morphogenesis? Humans and other organisms utilize feedback between movement and sensing known as ‘sensorimotor coordination’ or ‘active perception’ to inform behaviour, but act…
View article: Foxm1 regulates neuronal progenitor fate during spinal cord regeneration
Foxm1 regulates neuronal progenitor fate during spinal cord regeneration Open
Summary Mammals have limited tissue regeneration capabilities, particularly in the case of the central nervous system. Spinal cord injuries are often irreversible and lead to the loss of motor and sensory function below the site of the dam…
View article: Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis
Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis Open
Angiogenesis is driven by the coordinated collective branching of specialized leading "tip" and trailing "stalk" endothelial cells (ECs). While Notch-regulated negative feedback suppresses excessive tip selection, roles for positive feedba…
View article: Positive-feedback defines the timing and robustness of angiogenesis
Positive-feedback defines the timing and robustness of angiogenesis Open
SUMMARY Blood vessel formation by angiogenesis is critical for tissue development, homeostasis and repair, and is frequently dysregulated in disease[1–3]. Angiogenesis is triggered by vascular endothelial growth factor receptor-2/3 (VEGFR)…
View article: Analysis of neural progenitors from embryogenesis to juvenile adult in<i>Xenopus laevis</i>reveals biphasic neurogenesis and continuous lengthening of the cell cycle
Analysis of neural progenitors from embryogenesis to juvenile adult in<i>Xenopus laevis</i>reveals biphasic neurogenesis and continuous lengthening of the cell cycle Open
Xenopus laevis is a prominent model system for studying neural development, but our understanding of the long-term temporal dynamics of neurogenesis remains incomplete. Here, we present the first continuous description of neurogenesis in X…