Raphaël Tripier
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View article: Chemical Tools to Characterize the Coordination Chemistry of Radionuclides for Radiopharmaceutical Applications
Chemical Tools to Characterize the Coordination Chemistry of Radionuclides for Radiopharmaceutical Applications Open
During the past decade, the advancement and approval of novel radiopharmaceuticals for clinical application has led to a resurgence of the field of radiochemistry and specifically the coordination chemistry of radionuclides. In addition to…
View article: Targeting monocarboxylate transporter 1 with a copper-chelating coumarin-based bioconjugate: Synthesis and characterization
Targeting monocarboxylate transporter 1 with a copper-chelating coumarin-based bioconjugate: Synthesis and characterization Open
Monocarboxylate Transporters (MCTs), particularly MCT1, are increasingly recognized as key regulators of cancer metabolism, facilitating lactate exchange and contributing to tumor aggressiveness. Their overexpression in various malignancie…
View article: Clickable Pyclen‐Based Luminescent Lanthanide Complexes: Application to Two‐Photon Microscopy
Clickable Pyclen‐Based Luminescent Lanthanide Complexes: Application to Two‐Photon Microscopy Open
Lanthanide luminescent bioprobes incorporating a reactive group for the functionalization of biomolecules via click chemistry are of high interest for the straightforward preparation of smart luminescent tools for biological imaging and se…
View article: Synthesis and <sup>64</sup>Cu‐Radiolabeling Strategies of Small Organic Radioconjugates Based on the AMD070 Scaffold
Synthesis and <sup>64</sup>Cu‐Radiolabeling Strategies of Small Organic Radioconjugates Based on the AMD070 Scaffold Open
CXCR4 is a transmembrane receptor overexpressed in a large variety of cancer cells. In addition to classical antibody‐ and peptide‐targeting for the development of positron emission tomography (PET) radiopharmaceuticals, this receptor poss…
View article: Exploring the Coordination Chemistry and Potential Applications of PC3PA-Based Lanthanide Complexes: Synthesis, Solution Structure, Luminescence, and Relaxation Properties
Exploring the Coordination Chemistry and Potential Applications of PC3PA-Based Lanthanide Complexes: Synthesis, Solution Structure, Luminescence, and Relaxation Properties Open
The novel ligand H3PC3PA was synthesized from pyclen and methyl-6-(bromomethyl)picolinate with 82% overall yield, and its rare-earth complexes (La, Eu, Gd, Tb, Lu, Y) were isolated and characterized by HR-MS and analytical HPLC. Solution 1…
View article: Exploring Photophysical Properties and Sensitivity to Dioxygen in Anisolyl-Picolinate Antenna Conjugated to Azamacrocycles
Exploring Photophysical Properties and Sensitivity to Dioxygen in Anisolyl-Picolinate Antenna Conjugated to Azamacrocycles Open
An anisolyl-picolinate antenna grafted onto different macrocyclic ligands such as tacn, pyclen or cyclen renders the resulting terbium (III) complexes highly sensitive towards oxygen in aqueous solutions, enabling the design of ratiometric…
View article: Zn<sup>2+</sup> triazamacrocyclic chelators with methylpyridine pendant arms for B-cell apoptosis: a structure–activity study
Zn<sup>2+</sup> triazamacrocyclic chelators with methylpyridine pendant arms for B-cell apoptosis: a structure–activity study Open
Apoptosis of B-cells induced by triazamacrocyclic derivatives with methylpyridine arms with or without Zn 2+ chelation depending on the triazamacrocycle.
View article: Photochromic macrocyclic complexes of yttrium( <scp>iii</scp> ) undergoing merocyanine to spiropyran isomerization as models for single-molecule magnet switch candidates
Photochromic macrocyclic complexes of yttrium( <span>iii</span> ) undergoing merocyanine to spiropyran isomerization as models for single-molecule magnet switch candidates Open
The synthesis and characterization of four macrocyclic yttrium( iii ) or dysprosium( iii ) complexes bearing a merocyanine photochromic unit are reported.
View article: Upconversion Luminescence with Bis‐pyclen Yb(III) Chelates: Crown vs. Linear Polyether Linkers in Discrete Heteropolynuclear Architectures
Upconversion Luminescence with Bis‐pyclen Yb(III) Chelates: Crown vs. Linear Polyether Linkers in Discrete Heteropolynuclear Architectures Open
Ligands combining two lateral bis‐pyridyl‐phosphonated‐pyclens were synthesized, using a flexible linear pegylated linker ( L2 ) or a bulkier K22 crown‐ether ( L3 ). A functionalized pyridyl‐phosphonated‐pyclen ( L1 ) was also prepared as …
View article: Grafting a chromophore on AMD070 analogues for CXCR4 bioimaging: Chemical synthesis and in vitro assessment of the inhibition properties of the CXCR4 receptor
Grafting a chromophore on AMD070 analogues for CXCR4 bioimaging: Chemical synthesis and in vitro assessment of the inhibition properties of the CXCR4 receptor Open
Thank to their particular pharmacokinetics, the use of small organic molecules can be a very promising alternative to macromolecular targeting biomolecules (i.e. antibodies, peptides…) for specific imaging of tumours. Herein, the potential…
View article: Taylor dispersion analysis for measurement of diffusivity and size of gadolinium-based contrast agents
Taylor dispersion analysis for measurement of diffusivity and size of gadolinium-based contrast agents Open
Gadolinium-based contrast agents (GBCA) are complexes of a Gadolinium metal center and a linear or macrocyclic polyamino-carboxylic acid chelating agent. These agents are employed to enhance the visibility of deep abnormalities through MRI…
View article: Relevance of Oxocyclam from Palladium(II) Coordination to Radiopharmaceutical Development
Relevance of Oxocyclam from Palladium(II) Coordination to Radiopharmaceutical Development Open
We provide a comprehensive study of the coordination of oxocyclam with palladium(II), including presentation of a novel bifunctional analogue, p-H2N-Bn-oxocyclam, bearing an aniline pendant. The complexation of palladium(II) with oxocyclam…
View article: Extending the Scope of the <i>C</i>-Functionalization of Cyclam via Copper(I)-Catalyzed Alkyne–Azide Cycloaddition to Bifunctional Chelators of Interest
Extending the Scope of the <i>C</i>-Functionalization of Cyclam via Copper(I)-Catalyzed Alkyne–Azide Cycloaddition to Bifunctional Chelators of Interest Open
Cyclam, known for its potent chelation properties, is explored for diverse applications through selective N-functionalization, offering versatile ligands for catalysis, medical research, and materials science. The challenges arising from N…
View article: Selective synthesis of an elusive <i>C</i>-functional bis-cyclam and study of its inhibition of the CXCR4 chemokine receptor
Selective synthesis of an elusive <i>C</i>-functional bis-cyclam and study of its inhibition of the CXCR4 chemokine receptor Open
A rare example of C , C ′-linked bis-cyclam has been synthesized with controlled manner in mild conditions thanks to the “bis-aminal” tool, and its good CXCR4-recognition properties could be demonstated in vitro .
View article: Trehalose-polyamine/DNA nanocomplexes: impact of vector architecture on cell and organ transfection selectivity
Trehalose-polyamine/DNA nanocomplexes: impact of vector architecture on cell and organ transfection selectivity Open
A novel family of precision-engineered gene vectors with well-defined structures built on trehalose and trehalose-based macrocycles (cyclotrehalans) comprising linear or cyclic polyamine heads have been synthesized by click chemistry react…
View article: A versatile fluorinated azamacrocyclic chelator enabling <sup>18</sup>F PET or <sup>19</sup>F MRI: a first step towards new multimodal and smart contrast agents
A versatile fluorinated azamacrocyclic chelator enabling <sup>18</sup>F PET or <sup>19</sup>F MRI: a first step towards new multimodal and smart contrast agents Open
A new trifluoroborate-appended macrocyclic chelator presents suitable 19 F MRI signal and late-stage 18 F-radiolabeling, paving the way for the design of novel theranostic and smart imaging agents.
View article: Extending the scope of the C-functionalization of cyclam via Copper(I)-catalyzed Alkyne-Azide Cycloaddition to bifunctional chelators of interest
Extending the scope of the C-functionalization of cyclam via Copper(I)-catalyzed Alkyne-Azide Cycloaddition to bifunctional chelators of interest Open
Cyclam, known for its potent chelation properties, is explored for diverse applications through selective N-functionalization, offering versatile ligands for catalysis, medical research, and materials science. The challenges arising from N…
View article: Synthesis and Photophysical Properties of Lanthanide Pyridinylphosphonic Tacn and Pyclen Derivatives: From Mononuclear Complexes to Supramolecular Heteronuclear Assemblies
Synthesis and Photophysical Properties of Lanthanide Pyridinylphosphonic Tacn and Pyclen Derivatives: From Mononuclear Complexes to Supramolecular Heteronuclear Assemblies Open
Synthetic methodologies were developed to achieve the preparation of ligands L1 and L2 consisting of tacn- and pyclen-based chelators decorated with pyridinylphosphonic pendant arms combined with ethylpicolinamide or acetate coordinating f…
View article: CCDC 2256758: Experimental Crystal Structure Determination
CCDC 2256758: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Preclinical Evaluation of a 64Cu-Based Theranostic Approach in a Murine Model of Multiple Myeloma
Preclinical Evaluation of a 64Cu-Based Theranostic Approach in a Murine Model of Multiple Myeloma Open
Although the concept of theranostics is neither new nor exclusive to nuclear medicine, it is a particularly promising approach for the future of nuclear oncology. This approach is based on the use of molecules targeting specific biomarkers…
View article: CCDC 2238000: Experimental Crystal Structure Determination
CCDC 2238000: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: A Phosphine Oxide-Functionalized Cyclam as a Specific Copper(II) Chelator
A Phosphine Oxide-Functionalized Cyclam as a Specific Copper(II) Chelator Open
Although cyclam-based ligands are among the strongest copper(II) chelators available, they also usually present good affinity for other divalent cations [Zn(II), Ni(II), and Co(II)], with no copper(II)-specific cyclam ligands having been d…
View article: CCDC 2237998: Experimental Crystal Structure Determination
CCDC 2237998: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2237999: Experimental Crystal Structure Determination
CCDC 2237999: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2205613: Experimental Crystal Structure Determination
CCDC 2205613: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2160376: Experimental Crystal Structure Determination
CCDC 2160376: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2159600: Experimental Crystal Structure Determination
CCDC 2159600: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …