Raphael Wolfisberg
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View article: Development of a Norway Rat Hepacivirus Reporter for High-Throughput Quantification of Neutralising Antibodies
Development of a Norway Rat Hepacivirus Reporter for High-Throughput Quantification of Neutralising Antibodies Open
Hepatitis C virus (HCV) remains a major global health challenge, with vaccine research hindered by lack of immunocompetent animal models. Infection with the HCV-related Norway rat hepacivirus 1 (NrHV) in rats or mice shares HCV defining ch…
View article: In vivo and in vitro recombinant systems of a novel variant demonstrate cross-reactive neutralization for the HCV model virus, Norway rat hepacivirus
In vivo and in vitro recombinant systems of a novel variant demonstrate cross-reactive neutralization for the HCV model virus, Norway rat hepacivirus Open
The lack of immunocompetent animal models severely impedes the development of vaccines against hepatitis C virus (HCV) and researchers have therefore explored the application of surrogate virus models. Norway rat hepacivirus 1 (NrHV) is a …
View article: Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice
Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice Open
BACKGROUND AIMS: Human genetic variation is thought to guide the outcome of HCV infection, but model systems within which to dissect these host genetic mechanisms are limited. Norway rat hepacivirus, closely related to HCV, causes chronic …
View article: Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice
Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice Open
Background & Aims: Human genetic variation is thought to guide the outcome of HCV infection, but model systems within which to dissect these host genetic mechanisms are limited. Norway rat hepacivirus, closely related to HCV, causes chroni…
View article: Molecular Determinants of Mouse Adaptation of Rat Hepacivirus
Molecular Determinants of Mouse Adaptation of Rat Hepacivirus Open
A prophylactic vaccine is required to achieve the World Health Organization’s objective for hepatitis C virus elimination as a serious public health threat. However, the lack of robust immunocompetent animal models supporting hepatitis C v…
View article: Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice
Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice Open
Background & Aims Human genetic variation is thought to guide the outcome of hepatitis C virus (HCV) infection but model systems within which to dissect these host genetic mechanisms are limited. Norway rat hepacivirus (NrHV), closely rela…
View article: Neutralization and receptor use of infectious culture–derived rat hepacivirus as a model for HCV
Neutralization and receptor use of infectious culture–derived rat hepacivirus as a model for HCV Open
Background and Aims Lack of tractable immunocompetent animal models amenable to robust experimental challenge impedes vaccine efforts for HCV. Infection with rodent hepacivirus from Rattus norvegicus (RHV‐rn1) in rats shares HCV‐defining c…
View article: Pathogenesis, MicroRNA‐122 Gene‐Regulation, and Protective Immune Responses After Acute Equine Hepacivirus Infection
Pathogenesis, MicroRNA‐122 Gene‐Regulation, and Protective Immune Responses After Acute Equine Hepacivirus Infection Open
Background and Aims Equine hepacivirus (EqHV) is phylogenetically the closest relative of HCV and shares genome organization, hepatotropism, transient or persistent infection outcome, and the ability to cause hepatitis. Thus, EqHV studies …
View article: Equine pegiviruses cause persistent infection of bone marrow and are not associated with hepatitis
Equine pegiviruses cause persistent infection of bone marrow and are not associated with hepatitis Open
Pegiviruses frequently cause persistent infection (as defined by >6 months), but unlike most other Flaviviridae members, no apparent clinical disease. Human pegivirus (HPgV, previously GBV-C) is detectable in 1-4% of healthy individuals an…
View article: Replicons of a Rodent Hepatitis C Model Virus Permit Selection of Highly Permissive Cells
Replicons of a Rodent Hepatitis C Model Virus Permit Selection of Highly Permissive Cells Open
A vaccine against hepatitis C virus (HCV) is crucial for global control of this important pathogen, which induces fatal human liver diseases. Vaccine development has been hampered by the lack of immunocompetent animal models. Discovery of …
View article: Protoparvovirus Cell Entry
Protoparvovirus Cell Entry Open
The Protoparvovirus (PtPV) genus of the Parvoviridae family of viruses includes important animal pathogens and reference molecular models for the entire family. Some virus members of the PtPV genus have arisen as promising tools to treat t…
View article: Mouse models of acute and chronic hepacivirus infection
Mouse models of acute and chronic hepacivirus infection Open
New York City rats provide a gift to virologists Despite the development of curative drugs for hepatitis C virus (HCV) infection, global eradication of HCV will likely require a prophylactic vaccine. Progress toward a vaccine has been impe…
View article: Late Maturation Steps Preceding Selective Nuclear Export and Egress of Progeny Parvovirus
Late Maturation Steps Preceding Selective Nuclear Export and Egress of Progeny Parvovirus Open
Although the mechanism is not well understood, growing evidence indicates that the nonenveloped parvovirus minute virus of mice (MVM) may actively egress before passive release through cell lysis. We have dissected the late maturation step…