Raphaella W. L. So
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View article: Stochastic Misfolding Drives the Emergence of Distinct α-Synuclein Strains
Stochastic Misfolding Drives the Emergence of Distinct α-Synuclein Strains Open
The existence of α-synuclein conformational strains provides a potential explanation for the clinical and pathological differences among synucleinopathies such as Parkinson’s disease and multiple system atrophy. However, how distinct α-syn…
View article: G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis
G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis Open
Loss of dopaminergic neurons in Parkinson's disease (PD) is preceded by loss of synaptic dopamine (DA) and accumulation of proteinaceous aggregates. Linking these deficits is critical to restoring DA signaling in PD. Using murine and human…
View article: α-Synuclein strain propagation is independent of cellular prion protein expression in a transgenic synucleinopathy mouse model
α-Synuclein strain propagation is independent of cellular prion protein expression in a transgenic synucleinopathy mouse model Open
The cellular prion protein, PrP C , has been postulated to function as a receptor for α-synuclein, potentially facilitating cell-to-cell spreading and/or toxicity of α-synuclein aggregates in neurodegenerative disorders such as Parkinson’s…
View article: α-Synuclein Strain Propagation is Independent of Cellular Prion Protein Expression in Transgenic Mice
α-Synuclein Strain Propagation is Independent of Cellular Prion Protein Expression in Transgenic Mice Open
The cellular prion protein, PrP C , has been postulated to function as a receptor for α-synuclein, potentially facilitating cell-to-cell spreading and/or toxicity of α-synuclein aggregates in neurodegenerative disorders such as Parkinson’s…
View article: Upregulated pexophagy limits the capacity of selective autophagy
Upregulated pexophagy limits the capacity of selective autophagy Open
Selective autophagy is an essential process to maintain cellular homeostasis through the constant recycling of damaged or superfluous components. Over a dozen selective autophagy pathways mediate the degradation of diverse cellular substra…
View article: Upregulated pexophagy limits the capacity of selective autophagy
Upregulated pexophagy limits the capacity of selective autophagy Open
Selective autophagy is an essential mechanism to maintain organelle integrity and cellular homeostasis through the constant recycling of damaged or superfluous components. While distinct selective autophagy pathways mediate the degradation…
View article: The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson’s disease
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson’s disease Open
View article: Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy
Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy Open
Background Multiple system atrophy (MSA) is a neurodegenerative condition characterized by variable combinations of parkinsonism, autonomic failure, cerebellar ataxia and pyramidal features. Although the distribution of synucleinopathy cor…
View article: A novel approach to evaluate alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy
A novel approach to evaluate alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy Open
Several in vitro and in vivo findings have consistently shown that α-synuclein derived from multiple system atrophy (MSA) subjects has more seeding capacity than Parkinson’s disease-derived α-synuclein. However, reliable detection of α-syn…
View article: α-Synuclein strains target distinct brain regions and cell types
α-Synuclein strains target distinct brain regions and cell types Open
View article: Application of CRISPR genetic screens to investigate neurological diseases
Application of CRISPR genetic screens to investigate neurological diseases Open
View article: P1‐184: INSULIN RESISTANT NEURONS ARISEN FROM PERIPHERAL HYPERINSULINEMIA ARE SENESCENT AND CORRELATE WITH MEMORY IMPAIRMENT AND COGNITIVE DECLINE: IMPLICATIONS FOR ALZHEIMER'S DISEASE
P1‐184: INSULIN RESISTANT NEURONS ARISEN FROM PERIPHERAL HYPERINSULINEMIA ARE SENESCENT AND CORRELATE WITH MEMORY IMPAIRMENT AND COGNITIVE DECLINE: IMPLICATIONS FOR ALZHEIMER'S DISEASE Open
[Background] The risk of developing Alzheimer's disease (AD) is almost double in patients with insulin resistance. Prolong hyperinsulinemia is a major cause of insulin resistance. We presented in last year that peripheral hyperinsulinemia …
View article: Brain-Derived Neurotrophic Factor Elevates Activating Transcription Factor 4 (ATF4) in Neurons and Promotes ATF4-Dependent Induction of Sesn2
Brain-Derived Neurotrophic Factor Elevates Activating Transcription Factor 4 (ATF4) in Neurons and Promotes ATF4-Dependent Induction of Sesn2 Open
Activating transcription factor 4 (ATF4) plays important physiologic roles in the brain including regulation of learning and memory as well as neuronal survival and death. Yet, outside of translational regulation by the eIF2α-dependent str…
View article: A Traditional Chinese Medicine Approach in Treating Depression by Promoting Liver Qi Circulation: A Western Medicine Perspective
A Traditional Chinese Medicine Approach in Treating Depression by Promoting Liver Qi Circulation: A Western Medicine Perspective Open
Depression is a prevalent mental illness in developed countries. In Western medicine, experimental and clinical investigations have demonstrated that depression is associated with the dysregulation of neurotransmitter signaling, and sympto…