Rapita Sood
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View article: mRNA translation in astrocytes controls hippocampal long-term synaptic plasticity and memory
mRNA translation in astrocytes controls hippocampal long-term synaptic plasticity and memory Open
Activation of neuronal protein synthesis upon learning is critical for the formation of long-term memory. Here, we report that learning in the contextual fear conditioning paradigm engenders a decrease in eIF2α (eukaryotic translation init…
View article: PPM1G dephosphorylates eIF4E to reduce selective mRNA translation.
PPM1G dephosphorylates eIF4E to reduce selective mRNA translation. Open
The mRNA 5’cap-binding eukaryotic translation initiation factor 4E (eIF4E) plays a major role in control of mRNA translation in health and disease. One mechanism of regulation of eIF4E activity is via phosphorylation of eIF4E by MNK kinase…
View article: 4E-BP2–dependent translation in parvalbumin neurons controls epileptic seizure threshold
4E-BP2–dependent translation in parvalbumin neurons controls epileptic seizure threshold Open
Significance In numerous models of neurodevelopmental disorders and epilepsy, genetic mutations associated with enhanced mTORC1 activity engender an increase in the susceptibility to epileptic seizures. This study shows that the deletion o…
View article: Limited Proteolysis of Cyclooxygenase-2 Enhances Cell Proliferation
Limited Proteolysis of Cyclooxygenase-2 Enhances Cell Proliferation Open
Accumulating evidence suggests that the cyclooxygenase-2 (COX-2) enzyme has additional catalytic-independent functions. Here we show that COX-2 appears to be cleaved in mouse and human tumors, which led us to hypothesize that COX-2 proteol…
View article: Trace Fear Conditioning: Procedure for Assessing Complex Hippocampal Function in Mice
Trace Fear Conditioning: Procedure for Assessing Complex Hippocampal Function in Mice Open
The trace fear conditioning protocol is designed to measure hippocampal function in mice. The protocol includes a neutral conditioned stimulus (tone) and an aversive unconditioned stimulus (shock), separated in time by a trace interval. Th…
View article: Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties
Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties Open
Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of four known kinases that respond to cellular stress by deactivating the eukaryotic initiation factor 2 α (eIF2α) or other signal transduction cascades. Recently, both…
View article: Down-regulation of cyclooxygenase-2 by the carboxyl tail of the angiotensin II type 1 receptor.
Down-regulation of cyclooxygenase-2 by the carboxyl tail of the angiotensin II type 1 receptor. Open
VOLUME 289 (2014) PAGES 31473–31479 A grant was inadvertently omitted. The corrected grant footnote should read as follows. This work was supported by United States Binational Science Foundation Grant 2009246 and Israel Science Foundation …