Raquel Chacon Ruiz Martinez
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View article: Probing Dopaminergic Modulation via Subthalamic Stimulation: A Preclinical Perspective
Probing Dopaminergic Modulation via Subthalamic Stimulation: A Preclinical Perspective Open
Introduction: Subthalamic nucleus (STN) deep brain stimulation (DBS) is currently the gold standard symptomatic treatment for patients with levodopa therapy-induced complications in Parkinson’s disease (PD). However, even though the effici…
View article: Integrative Phosphoproteomic and Proteomic Analysis of <i>Candida albicans</i> Exposed to Oxidative Stress
Integrative Phosphoproteomic and Proteomic Analysis of <i>Candida albicans</i> Exposed to Oxidative Stress Open
Candida albicans is an opportunistic pathogen, which has recently been included in the high-priority list of pathogenic fungi by the World Health Organization (WHO). The scarce arsenal available to treat such invasive fungal infecti…
View article: Maternal immune response during pregnancy and neurodevelopmental outcomes: A longitudinal approach
Maternal immune response during pregnancy and neurodevelopmental outcomes: A longitudinal approach Open
View article: Neuroinflammation in the prefrontal-amygdala-hippocampus network is associated with maladaptive avoidance behaviour
Neuroinflammation in the prefrontal-amygdala-hippocampus network is associated with maladaptive avoidance behaviour Open
Maladaptive avoidance behaviour is often observed in patients suffering from anxiety and trauma- and stressor-related disorders. The prefrontal-amygdala-hippocampus network is implicated in learning and memory consolidation. Neuroinflammat…
View article: Efficacy of deep brain stimulation of the subthalamic nucleus versus globus pallidus internus on sensory complaints
Efficacy of deep brain stimulation of the subthalamic nucleus versus globus pallidus internus on sensory complaints Open
Pain control after deep brain stimulation (DBS) in Parkinson’s disease (PD) remains unclear. Following six months, subthalamic (STN)-DBS reduced sensory complaints related to parkinsonism and bodily discomfort, increasing central beta-endo…
View article: Improved Functional Limitations and Decreased Pain in Preoperative Period after Pericapsular Nerve Group Block in Proximal Femoral Fractures
Improved Functional Limitations and Decreased Pain in Preoperative Period after Pericapsular Nerve Group Block in Proximal Femoral Fractures Open
Background: Proximal femoral fractures commonly occur above 50 years and regional anesthesia could be a complement in the perioperative treatment of the patients. The use of pericapsular nerve group block (PENG Block) has been proposed to …
View article: Vagal electrostimulation in postoperative thoracic surgery reduces the systemic inflammatory response and cardiopulmonary complications: an experimental study in pigs
Vagal electrostimulation in postoperative thoracic surgery reduces the systemic inflammatory response and cardiopulmonary complications: an experimental study in pigs Open
Taken together, our data suggested that VNS should be considered a non-pharmacological tool in the prevention of the exacerbated inflammatory response responsible for severe clinical complications, especially in more aggressive surgical pr…
View article: Unravelling the Role of Habenula Subnuclei on Avoidance Response: Focus on Activation and Neuroinflammation
Unravelling the Role of Habenula Subnuclei on Avoidance Response: Focus on Activation and Neuroinflammation Open
Understanding the mechanisms responsible for anxiety disorders is a major challenge. Avoidance behavior is an essential feature of anxiety disorders. The two-way avoidance test is a preclinical model with two distinct subpopulations—the go…
View article: Reduction of aggressive behaviour following hypothalamic deep brain stimulation: Involvement of 5-HT1A and testosterone
Reduction of aggressive behaviour following hypothalamic deep brain stimulation: Involvement of 5-HT1A and testosterone Open
This study shows that pHyp-DBS reduces AB in mice via changes in testosterone and 5-HT1A mechanisms.
View article: Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours
Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours Open
Deep brain stimulation targeting the posterior hypothalamus (pHyp-DBS) is being investigated as a treatment for refractory aggressive behavior, but its mechanisms of action remain elusive. We conducted an integrated imaging analysis of a l…
View article: Author response: Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours
Author response: Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Methods Data availability References Decision letter Author response Article and author information Metrics Abstract Deep brain stimulatio…
View article: One year follow-up on a randomized study investigating serratus anterior muscle and pectoral nerves type I block to reduced neuropathic pain descriptors after mastectomy
One year follow-up on a randomized study investigating serratus anterior muscle and pectoral nerves type I block to reduced neuropathic pain descriptors after mastectomy Open
View article: Does TRODAT-1 SPECT Uptake Correlate with Cerebrospinal Fluid α-Synuclein Levels in Mid-Stage Parkinson’s Disease?
Does TRODAT-1 SPECT Uptake Correlate with Cerebrospinal Fluid α-Synuclein Levels in Mid-Stage Parkinson’s Disease? Open
Background: Parkinson’s disease (PD) is characterized by a progressive loss of nigrostriatal dopaminergic neurons with impaired motor and non-motor symptoms. It has been suggested that motor asymmetry could be caused due to an imbalance in…
View article: Regional anesthesia overview: historical aspects, dissemination, and safety
Regional anesthesia overview: historical aspects, dissemination, and safety Open
Regional anesthesia has been widely debated in the literature. This article presents a brief historical overview of regional anesthesia, including critical aspects for its dissemination. In addition, local anesthetics with less neuro and c…
View article: Unraveling the peripheral and local role of inflammatory cytokines in glioblastoma survival
Unraveling the peripheral and local role of inflammatory cytokines in glioblastoma survival Open
Glioblastoma (GBM) is a life-threatening disease that presents high morbidity and mortality. The standardized treatment protocol results in a global survival of less than three years in the majority of cases. Immunotherapies have gained wi…
View article: Effect of Subthalamic Stimulation and Electrode Implantation in the Striatal Microenvironment in a Parkinson’s Disease Rat Model
Effect of Subthalamic Stimulation and Electrode Implantation in the Striatal Microenvironment in a Parkinson’s Disease Rat Model Open
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is considered the gold-standard treatment for PD; however, underlying therapeutic mechanisms need to be comprehensively elucidated, especially in relation to glial cells. We aim…
View article: Habenula activation patterns in a preclinical model of neuropathic pain accompanied by depressive-like behaviour
Habenula activation patterns in a preclinical model of neuropathic pain accompanied by depressive-like behaviour Open
Pain and depression are complex disorders that frequently co-occur, resulting in diminished quality of life. The habenula is an epithalamic structure considered to play a pivotal role in the neurocircuitry of both pain and depression. The …
View article: Case report: 5 Years follow-up on posterior hypothalamus deep brain stimulation for intractable aggressive behaviour associated with drug-resistant epilepsy
Case report: 5 Years follow-up on posterior hypothalamus deep brain stimulation for intractable aggressive behaviour associated with drug-resistant epilepsy Open
View article: Bilateral Amygdala Radio-Frequency Ablation for Refractory Aggressive Behavior Alters Local Cortical Thickness to a Pattern Found in Non-refractory Patients
Bilateral Amygdala Radio-Frequency Ablation for Refractory Aggressive Behavior Alters Local Cortical Thickness to a Pattern Found in Non-refractory Patients Open
Aggressive behaviors comprise verbal and/or physical aggression directed toward oneself, others, or objects and are highly prevalent among psychiatric patients, especially patients diagnosed with autism spectrum disorder and severe intelle…
View article: Increased Anxiety-Like Behavior in the Acute Phase of a Preclinical Model of Periodontal Disease
Increased Anxiety-Like Behavior in the Acute Phase of a Preclinical Model of Periodontal Disease Open
Periodontal disease (PD) is an infectious-inflammatory oral disease that is highly prevalent among adolescence and adulthood and can lead to chronic orofacial pain and be associated with anxiety, stress and depression. This study aimed to …
View article: Beneficial nonmotor effects of subthalamic and pallidal neurostimulation in Parkinson’s disease
Beneficial nonmotor effects of subthalamic and pallidal neurostimulation in Parkinson’s disease Open
View article: Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder – ERRATUM
Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder – ERRATUM Open
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View article: Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder
Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder Open
Aggressive behaviour is a highly prevalent and devastating condition in autism spectrum disorder resulting in impoverished quality of life. Gold-standard therapies are ineffective in about 30% of patients leading to greater suffering. We i…
View article: Neuroinflammation, Pain and Depression: An Overview of the Main Findings
Neuroinflammation, Pain and Depression: An Overview of the Main Findings Open
Chronic pain is a serious public health problem with a strong affective-motivational component that makes it difficult to treat. Most patients with chronic pain suffer from severe depression; hence, both conditions coexist and exacerbate o…
View article: Dopamine modulates individual differences in avoidance behavior: A pharmacological, immunohistochemical, neurochemical and volumetric investigation
Dopamine modulates individual differences in avoidance behavior: A pharmacological, immunohistochemical, neurochemical and volumetric investigation Open
Avoidance behavior is a hallmark in pathological anxiety disorders and results in impairment of daily activities. Individual differences in avoidance responses are critical in determining vulnerability or resistance to anxiety disorders. D…
View article: Fully Automated Habenula Segmentation Provides Robust and Reliable Volume Estimation Across Large Magnetic Resonance Imaging Datasets, Suggesting Intriguing Developmental Trajectories in Psychiatric Disease
Fully Automated Habenula Segmentation Provides Robust and Reliable Volume Estimation Across Large Magnetic Resonance Imaging Datasets, Suggesting Intriguing Developmental Trajectories in Psychiatric Disease Open
Studies of habenula (Hb) function and structure provided evidence of its involvement in psychiatric disorders, including schizophrenia and bipolar disorder. Previous studies using magnetic resonance imaging (manual/semiautomated segmentati…
View article: Medial Posterior Hypothalamus Neuromodulation as a Potential Target for Intractable Aggressive Behavior: A Systematic Review
Medial Posterior Hypothalamus Neuromodulation as a Potential Target for Intractable Aggressive Behavior: A Systematic Review Open
View article: Characterization of Lactobacillus rhamnosus MP01 and Lactobacillus plantarum MP02 and Assessment of Their Potential for the Prevention of Gastrointestinal Infections in an Experimental Canine Model
Characterization of Lactobacillus rhamnosus MP01 and Lactobacillus plantarum MP02 and Assessment of Their Potential for the Prevention of Gastrointestinal Infections in an Experimental Canine Model Open
The aim of the present study was to evaluate the probiotic potential of Lactobacillus rhamnosus MP01 and Lactobacillus plantarum MP02, two strains isolated from canine milk. These two isolates were characterized in vitro
View article: Neurochemical effects of motor cortex stimulation in the periaqueductal gray during neuropathic pain
Neurochemical effects of motor cortex stimulation in the periaqueductal gray during neuropathic pain Open
OBJECTIVE Motor cortex stimulation (MCS) is a neurosurgical technique used to treat patients with refractory neuropathic pain syndromes. MCS activates the periaqueductal gray (PAG) matter, which is one of the major centers of the descendin…
View article: Clinical, imaging genetics and deformation based morphometry study of longitudinal changes after surgery for intractable aggressive behaviour
Clinical, imaging genetics and deformation based morphometry study of longitudinal changes after surgery for intractable aggressive behaviour Open
Intractable aggressive behaviour is a devastating behavioural disorder that reach 30% of psychiatric aggressive patients. Neuromodulatory surgeries may be treatment alternatives to reduce suffering. We investigated the outcomes of bilatera…