Raquel Guiomar
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View article: Probe-based metagenomic pathogen detection: advancing laboratory capacity for complex diagnosis
Probe-based metagenomic pathogen detection: advancing laboratory capacity for complex diagnosis Open
Probe-based pathogen enrichment, followed by NGS, is a promising tool for complex diagnosis, overcoming traditional challenges of shotgun metagenomics, namely small microbial/human genetic material ratio and demanding computational resourc…
View article: Genetic and Epidemiological Insights Into Respiratory Syncytial Virus Infections: A Comparative Study of Hospitalized Versus Community Cases in Portugal (2021–2023)
Genetic and Epidemiological Insights Into Respiratory Syncytial Virus Infections: A Comparative Study of Hospitalized Versus Community Cases in Portugal (2021–2023) Open
Background Respiratory syncytial virus (RSV) is the leading cause of acute respiratory infection (ARI) in young children, but its genetic diversity requires ongoing surveillance. Methods From 2021 to 2023, a total of 619 and 94 RSV‐positiv…
View article: A systematic review and meta-analysis of the relationship between emotion regulation, pain, depressive symptoms and quality of life in women with endometriosis
A systematic review and meta-analysis of the relationship between emotion regulation, pain, depressive symptoms and quality of life in women with endometriosis Open
This meta-analysis provides evidence that adaptive ER skills might positively influence symptomatology in younger women with endometriosis. To foster mental health and pain coping, psychological management with a focus on emotion regulatio…
View article: Modelling approaches for estimating vaccine effectiveness of consecutive SARS-CoV-2 variant sublineages in the absence of study-specific genetic sequencing data, VEBIS hospital network, Europe, 2023/24
Modelling approaches for estimating vaccine effectiveness of consecutive SARS-CoV-2 variant sublineages in the absence of study-specific genetic sequencing data, VEBIS hospital network, Europe, 2023/24 Open
Introduction Genetic changes in COVID-19 variants/sublineages (VSLs) can reduce vaccine effectiveness (VE). Timely VSL-specific VE estimates are essential, but study-specific VSL identification by whole genome sequencing (the “gold standar…
View article: The potential bias introduced into COVID-19 vaccine effectiveness studies at primary care level due to the availability of SARS-CoV-2 tests in the general population
The potential bias introduced into COVID-19 vaccine effectiveness studies at primary care level due to the availability of SARS-CoV-2 tests in the general population Open
Background With SARS-CoV-2 self-tests, persons with acute respiratory infections (ARI) can know their COVID-19 status. This may alter their decision to consult a general practitioner (GP), potentially biasing COVID-19 vaccine effectiveness…
View article: Probe-based metagenomic pathogen detection: an added-value for complex diagnosis
Probe-based metagenomic pathogen detection: an added-value for complex diagnosis Open
Probe-based pathogen enrichment, followed by NGS, is a promising tool for complex diagnosis, overcoming traditional challenges of shotgun metagenomics, namely small microbial/human genetic material ratio and demanding computational resourc…
View article: Risk factors for COVID-19 among healthcare workers: a hospital-based cohort study in Portugal
Risk factors for COVID-19 among healthcare workers: a hospital-based cohort study in Portugal Open
Background Healthcare workers (HCWs) have an increased risk of transmitting SARS-CoV-2 infection to frail patients and are also at higher risk of exposure. Hence, it is essential to understand the risk factors for infection of HCWs to limi…
View article: Immune Response Against Influenza in a Cohort of Repeatedly Vaccinated Adults During the 2017/2018 and 2018/2019 Seasons
Immune Response Against Influenza in a Cohort of Repeatedly Vaccinated Adults During the 2017/2018 and 2018/2019 Seasons Open
Background/Objectives: The influenza vaccination of healthcare workers (HCWs) is recommended each autumn and winter season by the relevant authorities in EU/EEA countries. The objective of this study was to evaluate the impact of repeated …
View article: COVID-19 Vaccine Effectiveness in Autumn and Winter 2022 to 2023 Among Older Europeans
COVID-19 Vaccine Effectiveness in Autumn and Winter 2022 to 2023 Among Older Europeans Open
Importance In the context of emerging SARS-CoV-2 variants or lineages and new vaccines, it is key to accurately monitor COVID-19 vaccine effectiveness (CVE) to inform vaccination campaigns. Objective To estimate the effectiveness of COVID-…
View article: Effectiveness of COVID-19 vaccines administered in the 2023 autumnal campaigns in Europe: Results from the VEBIS primary care test-negative design study, September 2023–January 2024
Effectiveness of COVID-19 vaccines administered in the 2023 autumnal campaigns in Europe: Results from the VEBIS primary care test-negative design study, September 2023–January 2024 Open
View article: The potential of tailed amplicons for SARS-CoV-2 detection in Nucleic Acid Lateral Flow Assays
The potential of tailed amplicons for SARS-CoV-2 detection in Nucleic Acid Lateral Flow Assays Open
Nucleic Acid Lateral Flow Assays (NALFAs) are a promising solution for the point-of-care detection of viruses like SARS-CoV-2. However, they show some drawbacks, such as the great dependency on the use of antibodies and the need for post-a…
View article: Seroprevalence of Protective Antibodies Against Influenza and the Reduction of the Influenza Incidence Rate: An Annual Repeated Cross‐Sectional Study From 2014 to 2019
Seroprevalence of Protective Antibodies Against Influenza and the Reduction of the Influenza Incidence Rate: An Annual Repeated Cross‐Sectional Study From 2014 to 2019 Open
Background Seroepidemiological studies provide estimates of population‐level immunity, prevalence/incidence of infections, and evaluation of vaccination programs. We assessed the seroprevalence of protective antibodies against influenza an…
View article: Change in Age profile of Respiratory Syncytial Virus disease over the course of annual epidemics: a multi-national study
Change in Age profile of Respiratory Syncytial Virus disease over the course of annual epidemics: a multi-national study Open
View article: COVID-19 vaccine effectiveness against symptomatic infection with SARS-CoV-2 BA.1/BA.2 lineages among adults and adolescents in a multicentre primary care study, Europe, December 2021 to June 2022
COVID-19 vaccine effectiveness against symptomatic infection with SARS-CoV-2 BA.1/BA.2 lineages among adults and adolescents in a multicentre primary care study, Europe, December 2021 to June 2022 Open
Background Scarce European data in early 2021 suggested lower vaccine effectiveness (VE) against SARS-CoV-2 Omicron lineages than previous variants. Aim We aimed to estimate primary series (PS) and first booster VE against symptomatic BA.1…
View article: Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021–2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study
Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021–2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study Open
Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of…
View article: Interim 2023/24 influenza A vaccine effectiveness: VEBIS European primary care and hospital multicentre studies, September 2023 to January 2024
Interim 2023/24 influenza A vaccine effectiveness: VEBIS European primary care and hospital multicentre studies, September 2023 to January 2024 Open
Influenza A viruses circulated in Europe from September 2023 to January 2024, with influenza A(H1N1)pdm09 predominance. We provide interim 2023/24 influenza vaccine effectiveness (IVE) estimates from two European studies, covering 10 count…
View article: Respiratory syncytial virus under 2 years of age: hospitalization trends and risk factors for severe disease Ó? preliminary data from the Portuguese sentinel network
Respiratory syncytial virus under 2 years of age: hospitalization trends and risk factors for severe disease Ó? preliminary data from the Portuguese sentinel network Open
Introduction and Objectives: Respiratory Syncytial Virus (RSV) infection is an important cause of hospitalization in children under five years. A national RSV sentinel network was set up in Portugal in April 2021. We describe the trends in…
View article: Vaccine effectiveness against influenza hospitalisation in adults during the 2022/2023 mixed season of influenza A(H1N1)pdm09, A(H3N2) and B circulation, Europe: VEBIS SARI VE hospital network
Vaccine effectiveness against influenza hospitalisation in adults during the 2022/2023 mixed season of influenza A(H1N1)pdm09, A(H3N2) and B circulation, Europe: VEBIS SARI VE hospital network Open
We conducted a multicentre hospital‐based test‐negative case–control study to measure vaccine effectiveness (VE) against PCR‐confirmed influenza in adult patients with severe acute respiratory infection (SARI) during the 2022/2023 influenz…
View article: Effectiveness of Covid-19 Vaccines Administered in the 2023 Autumnal Campaigns in Europe: Results from the Vebis Primary Care Test-Negative Design Study, September 2023–January 2024
Effectiveness of Covid-19 Vaccines Administered in the 2023 Autumnal Campaigns in Europe: Results from the Vebis Primary Care Test-Negative Design Study, September 2023–January 2024 Open
View article: The Potential Bias Introduced into COVID-19 Vaccine Effectiveness Studies at Primary Care Level Due to the Availability of SARS-CoV-2 Tests in the General Population
The Potential Bias Introduced into COVID-19 Vaccine Effectiveness Studies at Primary Care Level Due to the Availability of SARS-CoV-2 Tests in the General Population Open
View article: RSV-bacterial co-infection is associated with increased illness severity in hospitalized children - Results from a prospective sentinel surveillance study
RSV-bacterial co-infection is associated with increased illness severity in hospitalized children - Results from a prospective sentinel surveillance study Open
Purpose : During the autumn/winter respiratory syncytial virus (RSV) epidemics, bacterial co-infection is common and affects the severity of the disease. We aimed to understand the relationship between RSV-bacterial co-infections and clini…
View article: 889. The age of RSV cases changes consistently over the course of annual epidemics: potential insights into RSV transmission dynamics based on surveillance data from seven countries.
889. The age of RSV cases changes consistently over the course of annual epidemics: potential insights into RSV transmission dynamics based on surveillance data from seven countries. Open
Background RSV infections affects people of all ages but the seasonality of RSV among different age groups have not been thoroughly examined. In this study, we investigated changes in the age distribution of RSV cases during the course of …
View article: Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Omicron-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021 to 2022
Vaccine effectiveness against COVID-19 hospitalisation in adults (≥ 20 years) during Omicron-dominant circulation: I-MOVE-COVID-19 and VEBIS SARI VE networks, Europe, 2021 to 2022 Open
Introduction The I-MOVE-COVID-19 and VEBIS hospital networks have been measuring COVID-19 vaccine effectiveness (VE) in participating European countries since early 2021. Aim We aimed to measure VE against PCR-confirmed SARS-CoV-2 in patie…
View article: End of season 2022/2023 quadrivalent influenza vaccine effectiveness in preventing influenza in primary care in Portugal
End of season 2022/2023 quadrivalent influenza vaccine effectiveness in preventing influenza in primary care in Portugal Open
Using a test-negative case-control design, we aim to estimate influenza vaccine effectiveness (VE) against medically attended laboratory-confirmed influenza in Portugal in 2022/2023 season. Between week 41/2022 and week 14/2023, data on 59…
View article: Vaccine effectiveness against influenza hospitalisation in adults during the 2022/23 mixed season of influenza A(H1N1)pdm09, A(H3N2) and B circulation, Europe: VEBIS SARI VE hospital network
Vaccine effectiveness against influenza hospitalisation in adults during the 2022/23 mixed season of influenza A(H1N1)pdm09, A(H3N2) and B circulation, Europe: VEBIS SARI VE hospital network Open
We conducted a multicentre hospital-based test-negative case–control study to measure vaccine effectiveness (VE) against PCR-confirmed influenza in adult patients with severe acute respiratory infection (SARI) during the 2022/23 influenza …
View article: Comparative study between virus neutralisation testing and other serological methods detecting anti-SARS-CoV-2 antibodies in Europe, 2021
Comparative study between virus neutralisation testing and other serological methods detecting anti-SARS-CoV-2 antibodies in Europe, 2021 Open
One consequence of the ongoing coronavirus disease pandemic was the rapid development of both in-house and commercial serological assays detecting anti-SARS-CoV-2 antibodies, in an effort to reliably detect acute and past SARS-CoV-2 infect…
View article: Seroprevalence of SARS-CoV-2 specific antibodies in Portugal May 2020 - June 2022: results of four serial seroepidemiological surveys
Seroprevalence of SARS-CoV-2 specific antibodies in Portugal May 2020 - June 2022: results of four serial seroepidemiological surveys Open
Population Medicine considers the following types of articles:• Research Papers -reports of data from original research or secondary dataset analyses.• Review Papers -comprehensive, authoritative, reviews within the journal's scope.These i…
View article: New perspectives on respiratory syncytial virus surveillance at the national level: lessons from the COVID-19 pandemic
New perspectives on respiratory syncytial virus surveillance at the national level: lessons from the COVID-19 pandemic Open
Learning from the COVID-19 pandemic and considering the effects of this pandemic, we provide recommendations that can guide towards sustainable RSV surveillance with the potential to be integrated into the broader perspective of respirator…
View article: Effect of neuraminidase inhibitor (oseltamivir) treatment on outcome of hospitalised influenza patients, surveillance data from 11 EU countries, 2010 to 2020
Effect of neuraminidase inhibitor (oseltamivir) treatment on outcome of hospitalised influenza patients, surveillance data from 11 EU countries, 2010 to 2020 Open
Background Timely treatment with neuraminidase inhibitors (NAI) can reduce severe outcomes in influenza patients. Aim We assessed the impact of antiviral treatment on in-hospital deaths of laboratory-confirmed influenza patients in 11 Euro…
View article: Monitoring COVID‐19 and Influenza: The Added Value of a Severe Acute Respiratory Infection Surveillance System in Portugal
Monitoring COVID‐19 and Influenza: The Added Value of a Severe Acute Respiratory Infection Surveillance System in Portugal Open
Background . Severe acute respiratory infections (SARI) surveillance is recommended to assess the severity of respiratory infections disease. In 2021, the National Institute of Health Doutor Ricardo Jorge, in collaboration with two general…