Explanipedia

Impactos da dieta plant-based na prevenção e controle das doenças crônicas não transmissíveis: revisão narrativa Open

Germana Costa Rocha, Raquel Costa, Damião Pergentino de Sousa, V. Rodrigues, Amanda Suellen Santana Alves , et al. · 2025

As doenças crônicas não transmissíveis (DCNTs) representam um dos maiores desafios de saúde pública mundial. Entre elas, destacam-se o diabetes tipo 2, as doenças cardiovasculares, a obesidade e síndrome metabólica, além de diversos tipos …

Correction to: Endothelial dysfunction in cardiovascular diseases: mechanisms and in vitro models Open

Ana Grego, Cristiana Fernandes, Ivo Fonseca, Marina Dias‐Neto, Raquel Costa , et al. · 2025

Microvascular, Biochemical, and Clinical Impact of Hyperbaric Oxygen Therapy in Recalcitrant Diabetic Foot Ulcers Open

Daniela Martins‐Mendes, Raquel Costa, Ilda Rodrigues, Óscar Camacho, Pedro Barata , et al. · 2025

Background: Diabetic foot ulcers (DFUs) are a serious complication of diabetes and are often difficult to treat. Hyperbaric oxygen therapy (HBOT) has been proposed as an adjunctive treatment to promote healing, but its long-term clinical a…

Silk fibroin microparticles as a candidate for wound healing applications: evaluating the role of adenosine Open

Beatriz G. Bernardes, Rossella Laurano, Clara López‐Iglesias, Rui Magalhães, Raquel Costa , et al. · 2025

In this study, silk fibroin (SF) aerogel microparticles were developed as a delivery system for adenosine (ADO) to exploit its anti-inflammatory and regenerative properties for wound healing. Supercritical CO₂ drying was used to…

Nanostructured lipid carrier-embedded hydrogels for enhanced skin delivery of quercetin: Optimized formulation with pomegranate oil for UVB protection Open

Raquel Costa, Cláudia Nunes, Sofia A. Costa Lima, Paula Gameiro, Salette Reis · 2025

Nanoparticle-embedded hydrogels are promising delivery systems for cutaneous applications. This study aimed to enhance skin delivery and bioavailability of quercetin, a biologically active flavonoid using nanostructured lipid carriers (NLC…

Endothelial dysfunction in cardiovascular diseases: mechanisms and in vitro models Open

Ana Grego, Cristiana Fernandes, Ivo Fonseca, Marina Dias‐Neto, Raquel Costa , et al. · 2025

Avaliação e revisão curricular: desafios e perspectivas na prática educacional Open

Marcos Sanches, Adriana Maria Almeida de Souza Belesk, Ernesto L. Barrera, Eunice Alves Sardinha, Herberth Gomes Ferreira , et al. · 2025

Este estudo teve como objetivo analisar os desafios e as perspectivas da avaliação e revisão curricular na prática educacional. O problema de pesquisa abordou as dificuldades enfrentadas pelos gestores e professores na implementação de prá…

Advancing diabetes treatment: from human beta cell technology to bioartificial pancreas development Open

Joana Sá, Simone C. Sá, Hélène Leménager, Raquel Costa, Brigitte Onténiente , et al. · 2025

In 2021, approximately 537 million people worldwide, primarily in low- and middle-income countries, were affected by diabetes, leading to approximately 6.7 million deaths annually or severe secondary complications including life-threatenin…

Acute intravascular haemolysis rapidly shifts the balance of angiogenic factors and accelerates neovascularization in vivo Open

Érica M.F. Gotardo, Pâmela L. Brito, Flávia C. Leonardo, Raquel Costa, Raquel Soares , et al. · 2025

Navigating Alternative Medicine Preferences in Palliative Care: Challenges and Collaborative Solutions Open

Paula Cerqueira, Sara Pereira, Raquel Costa, A. Gomes · 2025

Cutaneous Manifestation of Acute Lymphoblastic Leukemia Open

Paula Cerqueira, Sara Pereira, Raquel Costa, A. Gomes · 2024

Kappa index in the diagnosis of multiple sclerosis Open

Rodrigo Pereira, Maria Lúcia Vellutini Pimentel, Carlos Brandão, Vanessa Silva Miranda, Letı́cia Lessa Mansur , et al. · 2024

ALÉM DA TELA: INTEGRANDO A TECNOLOGIA DE FORMA SIGNIFICATIVA NA EDUCAÇÃO Open

Andreia Cristina Rodrigues Pires, Émerson Silva Lima, Raquel Costa, Carla Costa, Renata Gomes de Oliveira Gusson · 2023

A integração significativa da tecnologia na educação se apresenta como um paradigma emergente que otimiza os processos de ensino e aprendizagem por meio de recursos digitais. A escolha deste tema justifica-se pela relevância contemporânea …

Expanding the Potential of Self-Assembled Silk Fibroin as Aerogel Particles for Tissue Regeneration Open

Beatriz G. Bernardes, Sara Baptista-Silva, Carlos Illanes-Bordomás, Rui Magalhães, Juliana R. Dias , et al. · 2023

A newly produced silk fibroin (SF) aerogel particulate system using a supercritical carbon dioxide (scCO2)-assisted drying technology is herein proposed for biomedical applications. Different concentrations of silk fibroin (3%, 5%, and 7% …

Exploring the Anti-Cancer Properties of Pomegranate Peel Aqueous Extract Open

Carla Luís, André Sousa, Raquel Costa, A. Maduro, Patrick J. Pais , et al. · 2023

The objective of this work is to evaluate the influence of pomegranate peel extract (PPE) in the behavior of breast cell lines (epithelial and tumor type) and related oxidative metabolism. Fruit-based functional foods have been the target …

Tannic Acid Tailored-Made Microsystems for Wound Infection Open

Inês Guimarães, Raquel Costa, Sara Madureira, Sandra Borges, Ana L. Oliveira , et al. · 2023

Difficult-to-treat infections make complex wounds a problem of great clinical and socio-economic impact. Moreover, model therapies of wound care are increasing antibiotic resistance and becoming a critical problem, beyond healing. Therefor…

Impact of umbilical cord mesenchymal stromal/stem cell secretome and cord blood serum in prostate cancer progression Open

André Sousa, Pedro Coelho, Fernanda Leite, Catarina Teixeira, Ana Catarina Rocha , et al. · 2023

Prostate cancer (PCa) is the second most common malignancy in men, and the fifth leading cause of death worldwide. Mesenchymal stromal/stem cells (MSC) have been identified in PCa, although contradictory effects in malignant transformation…

Type 2 Diabetes mellitus alters the cargo of (poly)phenol metabolome and the oxidative status in circulating lipoproteins Open

Ana Reis, Sara Rocha, Irundika H.K. Dias, Raquel Costa, Raquel Soares , et al. · 2022

Review of the Use of GIS in Public Health and Food Safety Open

Ana Francisca Jijón, Raquel Costa, Klara Nicova, Giandomenico Furnari · 2022

The use of geographic information systems (GIS) is increasingly common in the scientific domains of public health and food safety.In this paper, we present the results of three analyses that we conducted to explore the application of GIS i…

Exploring Silk Sericin for Diabetic Wounds: An In Situ-Forming Hydrogel to Protect against Oxidative Stress and Improve Tissue Healing and Regeneration Open

Sara Baptista-Silva, Beatriz G. Bernardes, Sandra Borges, Ilda Rodrigues, Rui Fernandes , et al. · 2022

Chronic wounds are one of the most frequent complications that are associated with diabetes mellitus. The overproduction of reactive oxygen species (ROS) is a key factor in the delayed healing of a chronic wound. In the present work, we de…

The Impact of Metabolic Syndrome and Type 2 Diabetes Mellitus on Prostate Cancer Open

André Sousa, Raquel Costa, Marco G. Alves, Raquel Soares, Pilar Baylina , et al. · 2022

Prostate cancer (PCa) remains the second most common type of cancer in men worldwide in 2020. Despite its low death rate, the need for new therapies or prevention strategies is critical. The prostate carcinogenesis process is complex and m…

Congenital Diaphragmatic Hernia: Late Presentation Open

Raquel Costa, Pedro Patrao, Sílvia R. Coutinho, Sara Santos · 2022

Congenital diaphragmatic hernia is a rare condition, which typically manifests in the first \nhours of life with severe respiratory distress. With this article, we intend to draw \nattention to congenital diaphragmatic hernia in the differ…

Unveiling the Metabolic Effects of Glycomacropeptide Open

Maria Pena, Raquel Costa, Ilda Rodrigues, Sandra Martins, João Tiago Guimarães , et al. · 2021

For many years, the main nitrogen source for patients with phenylketonuria (PKU) was phenylalanine-free amino acid supplements. Recently, casein glycomacropeptide (GMP) supplements have been prescribed due to its functional and sensorial p…

Prostate Cancer Cell Lines Inhibition by Umbilical Cord Blood Serum Open

Raquel Costa, André Sousa, Raquel Soares, Andreia Gomes · 2021

On the Development of a Cutaneous Flavonoid Delivery System: Advances and Limitations Open

Raquel Costa, Sofia A. Costa Lima, Paula Gameiro, Salette Reis · 2021

Flavonoids are one of the vital classes of natural polyphenolic compounds abundantly found in plants. Due to their wide range of therapeutic properties, which include antioxidant, anti-inflammatory, photoprotective, and depigmentation effe…

Kluver-Bucy Syndrome: A Rare Complication of Herpes Simplex Encephalitis Open

Raquel Costa, Tiago Mendes, Joana Fontes, Marta Pereira, Carlos E. Gonçalves · 2021

Kluver-Bucy syndrome (KBS) is a characterized by a group of cognitive dysfunctions that include hypersexuality, placidity, hyperorality, memory deficits and hypermetamorphosis. This syndrome is often seen in pathological states that destro…

Metformin Reduces Vascular Assembly in High Glucose-Treated Human Microvascular Endothelial Cells in An AMPK-Independent Manner. Open

Carolina Silva, Ilda Rodrigues, Sara Andrade, Raquel Costa, Raquel Soares · 2021

Our data showed that metformin prevents vessel assembly in HMECs, probably through an AMPKindependent mechanism. Understanding the molecular mechanisms by which this pharmacological agent affects endothelial dysfunction is of paramount imp…

Bioaerogels: Promising Nanostructured Materials in Fluid Management, Healing and Regeneration of Wounds Open

Beatriz G. Bernardes, Pasquale Del Gaudio, Paulo Alves, Raquel Costa, Carlos A. García‐González , et al. · 2021

Wounds affect one’s quality of life and should be managed on a patient-specific approach, based on the particular healing phase and wound condition. During wound healing, exudate is produced as a natural response towards healing. However, …

Antiangiogenic and Antioxidant In Vitro Properties of Hydroethanolic Extract from açaí (Euterpe oleracea) Dietary Powder Supplement Open

Raquel Costa, Daniela Aguiar Azevedo, Pedro Barata, Raquel Soares, Luís F. Guido , et al. · 2021

The Euterpe oleracea fruit (açaí) is a promising source of polyphenols with health-promoting properties. To our knowledge, few studies have focused on the influence of açaí phytochemicals on angiogenesis, with a significant impact on cance…

Biocompatibility of the Biopolymer Cyanoflan for Applications in Skin Wound Healing Open

Raquel Costa, Luís Maltez, Ilda Rodrigues, Catarina Meireles, Raquel Soares , et al. · 2021

There is a great demand for the development of novel wound dressings to overcome the time and costs of wound care performed by a vast number of clinicians, especially in the current overburdened healthcare systems. In this study, Cyanoflan…

Raquel Costa YOU? Author Swipe