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View article: Association of Advanced Glycation End Products with Diabetic Retinopathy Severity in Lithuanian Patients
Association of Advanced Glycation End Products with Diabetic Retinopathy Severity in Lithuanian Patients Open
Background and Objectives: Diabetic retinopathy (DR) is a major microvascular complication of diabetes mellitus (DM) and a leading cause of blindness among working-age adults. Advanced glycation end products (AGEs) contribute to DR pathoge…
View article: Insights into FGFR4 (rs351855 and rs7708357) Gene Variants, Ki-67 and p53 in Pituitary Adenoma Pathophysiology
Insights into FGFR4 (rs351855 and rs7708357) Gene Variants, Ki-67 and p53 in Pituitary Adenoma Pathophysiology Open
To determine the association between FGFR4 (rs351855 and rs7708357) gene variants, serum levels, and immunohistochemical markers (Ki-67 and p53) in pituitary adenoma (PA), a case-control study was conducted involving 300 subjects divided i…
View article: Comparison of Validity and Reliability of Manual Consensus Grading vs. Automated AI Grading for Diabetic Retinopathy Screening in Oslo, Norway: A Cross-Sectional Pilot Study
Comparison of Validity and Reliability of Manual Consensus Grading vs. Automated AI Grading for Diabetic Retinopathy Screening in Oslo, Norway: A Cross-Sectional Pilot Study Open
Background: Diabetic retinopathy (DR) is a leading cause of visual impairment worldwide. Manual grading of fundus images is the gold standard in DR screening, although it is time-consuming. Artificial intelligence (AI)-based algorithms off…
View article: The Association of Thyroid Disease with Risk of Dementia and Cognitive Impairment: A Systematic Review
The Association of Thyroid Disease with Risk of Dementia and Cognitive Impairment: A Systematic Review Open
Background and Objectives: Cognitive impairment is defined as a reduced ability to perform one or more cognitive functions, potentially leading to dementia if the condition worsens. With dementia being a rapidly growing public health issue…
View article: Plasma miRNA-146b-3p, -222-3p, -221-5p, -21a-3p Expression Levels and TSHR Methylation: Diagnostic Potential and Association with Clinical and Pathological Features in Papillary Thyroid Cancer
Plasma miRNA-146b-3p, -222-3p, -221-5p, -21a-3p Expression Levels and TSHR Methylation: Diagnostic Potential and Association with Clinical and Pathological Features in Papillary Thyroid Cancer Open
This study aimed to investigate the expression of microRNAs (miRNAs) -146b-3p, -221-5p, -222-3p, and -21a-3p and the methylation pattern of the thyroid-stimulating hormone receptor (TSHR) gene in blood plasma samples from papillary thyroid…
View article: A pilot cost-analysis study comparing AI-based EyeArt® and ophthalmologist assessment of diabetic retinopathy in minority women in Oslo, Norway
A pilot cost-analysis study comparing AI-based EyeArt® and ophthalmologist assessment of diabetic retinopathy in minority women in Oslo, Norway Open
Background Diabetic retinopathy (DR) is the leading cause of adult blindness in the working age population worldwide, which can be prevented by early detection. Regular eye examinations are recommended and crucial for detecting sight-threa…
View article: Impact of Nutrient Intake on Body Composition in Very Low-Birth Weight Infants Following Early Progressive Enteral Feeding
Impact of Nutrient Intake on Body Composition in Very Low-Birth Weight Infants Following Early Progressive Enteral Feeding Open
Preterm infants have increased body adiposity at term-equivalent age and risk of adverse metabolic outcomes. The aim of the study was to define how nutrient intake may impact body composition (BC) of very low-birth weight infants fed with …
View article: Automatic Detection of Microaneurysms in Fundus Images Using an Ensemble-Based Segmentation Method
Automatic Detection of Microaneurysms in Fundus Images Using an Ensemble-Based Segmentation Method Open
In this study, a novel method for automatic microaneurysm detection in color fundus images is presented. The proposed method is based on three main steps: (1) image breakdown to smaller image patches, (2) inference to segmentation models, …
View article: The COVID-19 Pandemic Affects Seasonality, With Increasing Cases of New-Onset Type 1 Diabetes in Children, From the Worldwide SWEET Registry
The COVID-19 Pandemic Affects Seasonality, With Increasing Cases of New-Onset Type 1 Diabetes in Children, From the Worldwide SWEET Registry Open
OBJECTIVE To analyze whether the coronavirus disease 2019 (COVID-19) pandemic increased the number of cases or impacted seasonality of new-onset type 1 diabetes (T1D) in large pediatric diabetes centers globally. RESEARCH DESIGN AND METHOD…
View article: Pancreatic beta‐cell function dynamics in youth with <scp> <i>GCK</i> </scp> , <scp> <i>HNF1A</i> </scp> , and <scp> <i>KCNJ11</i> </scp> genes mutations during mixed meal tolerance test
Pancreatic beta‐cell function dynamics in youth with <span> <i>GCK</i> </span> , <span> <i>HNF1A</i> </span> , and <span> <i>KCNJ11</i> </span> genes mutations during mixed meal tolerance test Open
In short-term perspective, GCK diabetes group revealed no deterioration of beta-cell function. Individualized treatment in monogenic diabetes showed improved beta-cell function.
View article: Peer Review #3 of "Ubiquitin-proteasome system in diabetic retinopathy (v0.2)"
Peer Review #3 of "Ubiquitin-proteasome system in diabetic retinopathy (v0.2)" Open
Diabetic retinopathy (DR) is the most common complication of diabetes, being the most prevalent reason for blindness among the working-age population in the developed world.Despite constant improvement of understanding of the pathogenesis …
View article: Telomere Lengths and Serum Proteasome Concentrations in Patients with Type 1 Diabetes and Different Severities of Diabetic Retinopathy in Latvia and Lithuania
Telomere Lengths and Serum Proteasome Concentrations in Patients with Type 1 Diabetes and Different Severities of Diabetic Retinopathy in Latvia and Lithuania Open
The aim of the study was to compare telomere lengths and circulating proteasome concentrations in patients with different stages of diabetic retinopathy and type 1 diabetes in Latvia and Lithuania. Methods. Patients with no diabetic retino…
View article: Serum Cystatin C as a Biomarker for Early Diabetic Kidney Disease and Dyslipidemia in Young Type 1 Diabetes Patients
Serum Cystatin C as a Biomarker for Early Diabetic Kidney Disease and Dyslipidemia in Young Type 1 Diabetes Patients Open
Background and objectives: This study aimed to assess the clinical significance of serum cystatin C in the early diagnosis of renal injury and its association with dyslipidemia in young T1D patients. Materials and Methods: A total of 779 s…
View article: Colorimetric and Electrochemical Screening for Early Detection of Diabetes Mellitus and Diabetic Retinopathy—Application of Sensor Arrays and Machine Learning
Colorimetric and Electrochemical Screening for Early Detection of Diabetes Mellitus and Diabetic Retinopathy—Application of Sensor Arrays and Machine Learning Open
In this review, a selection of works on the sensing of biomarkers related to diabetes mellitus (DM) and diabetic retinopathy (DR) are presented, with the scope of helping and encouraging researchers to design sensor-array machine-learning …
View article: ESE Clinical Practice Guideline on functioning and nonfunctioning pituitary adenomas in pregnancy
ESE Clinical Practice Guideline on functioning and nonfunctioning pituitary adenomas in pregnancy Open
Pregnancies are rare in women with pituitary adenomas, which may relate to hormone excess from secretory subtypes such as prolactinomas or corticotroph adenomas. Decreased fertility may also result from pituitary hormone deficiencies due t…
View article: Kinetics of C-peptide during mixed meal test and its value for treatment optimization in monogenic diabetes patients
Kinetics of C-peptide during mixed meal test and its value for treatment optimization in monogenic diabetes patients Open
A pretreatment challenge with MMTT might be used to guide the optimal treatment after molecular diagnosis of MD.
View article: Prevalence of Metabolic Syndrome and Impaired Glucose Metabolism among 10- to 17-Year-Old Overweight and Obese Lithuanian Children and Adolescents
Prevalence of Metabolic Syndrome and Impaired Glucose Metabolism among 10- to 17-Year-Old Overweight and Obese Lithuanian Children and Adolescents Open
Background: Overweight (Ow) and obesity among adults and children increases the risk of metabolic consequences. Metabolic syndrome (MS) and impaired glucose metabolism are well-known risk factors for cardiovascular diseases a…
View article: WITHDRAWN: Serum Cystatin C as a Biomarker for Early Diabetic Nephropathy and Dyslipidemia in Young Type 1 Diabetes Patients
WITHDRAWN: Serum Cystatin C as a Biomarker for Early Diabetic Nephropathy and Dyslipidemia in Young Type 1 Diabetes Patients Open
Background. Early capture of initial stages of complications is the destination of long term follow up of type 1 diabetes (T1D) patients. The aim of this study was to assess the clinical significance of serum cystatin C in the early diagno…
View article: Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen
Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen Open
Significance Statement Although studies show that diabetic kidney disease has a heritable component, searches for the genetic determinants of this complication of diabetes have had limited success. In this study, a new international genomi…
View article: The cost of macro- and microvascular diseases in patients with diabetes mellitus in selected Central and Eastern European countries
The cost of macro- and microvascular diseases in patients with diabetes mellitus in selected Central and Eastern European countries Open
Background Macro- and microvascular diseases (MMVDs) in diabetes mellitus (DM) are important clinical and economic burdens. Reimbursement decisions require substantiated information; however, for Central and Eastern European (CEE) countrie…
View article: Factors Affecting Cardiovascular Risk in Children, Adolescents, and Young Adults with Type 1 Diabetes
Factors Affecting Cardiovascular Risk in Children, Adolescents, and Young Adults with Type 1 Diabetes Open
Cardiovascular risk and obesity are becoming major health issues among individuals with type 1 diabetes (T1D). The aim of this study was to evaluate cardiovascular risk factors and obesity in youth with T1D in Lithuania. Methods . 883 pati…
View article: SAT-LB096 Relationship between MicroRNA Expression Levels and Clinicopathological Parameters and Recurrence of Papillary Thyroid Carcinoma
SAT-LB096 Relationship between MicroRNA Expression Levels and Clinicopathological Parameters and Recurrence of Papillary Thyroid Carcinoma Open
Introduction: Papillary thyroid carcinoma (PTC) is the most common type of endocrine cancer. Although PTC is a malignancy that has a good prognosis, disease progression occurs in up to 20 % of patients. Currently, recurrence risk stratific…
View article: Corrigendum to “Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects”
Corrigendum to “Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects” Open
[This corrects the article DOI: 10.1155/2017/8401518.].
View article: Genome-wide association study of diabetic kidney disease highlights biology involved in renal basement membrane collagen
Genome-wide association study of diabetic kidney disease highlights biology involved in renal basement membrane collagen Open
Diabetic kidney disease (DKD) is a heritable but poorly understood complication of diabetes. To identify genetic variants predisposing to DKD, we performed genome-wide association analyses in 19,406 individuals with type 1 diabetes (T1D) u…
View article: The impact of FSH receptor polymorphism on time-to-pregnancy: a cross-sectional single-centre study
The impact of FSH receptor polymorphism on time-to-pregnancy: a cross-sectional single-centre study Open
The results suggest a possible relationship of FSH receptor gene Serine/Serine variant for the lower possibility of conception during the first 12 months of planned conception.
View article: Can coefficient of variation of time-domain analysis be valuable for detecting cardiovascular autonomic neuropathy in young patients with type 1 diabetes: a case control study
Can coefficient of variation of time-domain analysis be valuable for detecting cardiovascular autonomic neuropathy in young patients with type 1 diabetes: a case control study Open
Time and frequency domain analysis of HRV permits a more accurate evaluation of cardiovascular autonomic function, providing more information about sympathetic and parasympathetic activity. The coefficient of variation (time-domain analysi…
View article: Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects
Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects Open
The aim of the present study was to determine associations of thyroid hormone levels and different metabolic parameters and anthropometric measurements with volume of nodular and nonnodular thyroid as well as with prevalence of goiter and …
View article: International Medical Section : 75th Conference of the University of Latvia : Book of Abstracts
International Medical Section : 75th Conference of the University of Latvia : Book of Abstracts Open
Supported by: Faculty of Medicine, University of Latvia, Latvijas Inovatīvās medicīnas fonds, Latvijas Invazīvās kardioloģijas attīstības biedrība, AS “Sistēmu Inovācijas”, Doktorantūras skola “Translācijas izpētē medicīnā”
View article: Thirty-Five Years of Thyroid Cancer Experience in a Paediatric Population: Incidence Trends in Lithuania between 1980 and 2014
Thirty-Five Years of Thyroid Cancer Experience in a Paediatric Population: Incidence Trends in Lithuania between 1980 and 2014 Open
The incidence of TC in the Lithuanian paediatric population between 1980 and 2014 ranged from 0 to 0.93 cases per 100,000 children per year and there was a 5.26% annual increase (p < 0.001), most probably related to the increased use of ul…
View article: Comparison the sexuality of 26 - 36-years-old Lithuanian healthy and type-1 diabetic males with older than 40 years men sexuality of 8 European countries
Comparison the sexuality of 26 - 36-years-old Lithuanian healthy and type-1 diabetic males with older than 40 years men sexuality of 8 European countries Open
Aims. Sexuality of 26-36-year-old type 1 diabetes mellitus patients (T1D) was compared with published results of sexuality of healthy men from general population (HM) and sexuality of European Male Ageing Study (EMAS) different age more th…