Rasheed Sule
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View article: Partial restoration of mitochondrial dysfunction by AAV-Ant1 protects from dilated cardiomyopathy in Ant1-/- plus mtDNA mutant mice
Partial restoration of mitochondrial dysfunction by AAV-Ant1 protects from dilated cardiomyopathy in Ant1-/- plus mtDNA mutant mice Open
Primary mitochondrial disease (PMD) patients manifesting cardiomyopathy are twice as likely to die as other PMD patients. One PMD with cardiomyopathy is caused by null mutations in the heart-muscle isoform of the adenine nucleotide translo…
View article: Environmental Toxins and Oxidative Stress: The Link to Cardiovascular Diseases
Environmental Toxins and Oxidative Stress: The Link to Cardiovascular Diseases Open
Cardiovascular diseases (CVDs) remain a leading global health concern, responsible for substantial morbidity and mortality. In recent years, as our understanding of the multifaceted nature of CVDs has increased, it has become increasingly …
View article: Comprehensive Multiomic Analysis Reveals Metabolic Reprogramming Underlying Human Fontan‐Associated Liver Disease
Comprehensive Multiomic Analysis Reveals Metabolic Reprogramming Underlying Human Fontan‐Associated Liver Disease Open
Background The Fontan operation is the current standard of care for single‐ventricle congenital heart disease. Almost all patients with Fontan operation develop liver fibrosis at a young age, known as Fontan‐associated liver disease (FALD)…
View article: Guidelines on antibody use in physiology research
Guidelines on antibody use in physiology research Open
Antibodies are one of the most used reagents in scientific laboratories and are critical components for a multitude of experiments in physiology research. Over the past decade, concerns about many biological methods, including those that u…
View article: Mitochondrial and Proteasome Dysfunction Occurs in the Hearts of Mice Treated with Triazine Herbicide Prometryn
Mitochondrial and Proteasome Dysfunction Occurs in the Hearts of Mice Treated with Triazine Herbicide Prometryn Open
Prometryn is a methylthio-s-triazine herbicide used to control the growth of annual broadleaf and grass weeds in many cultivated plants. Significant traces of prometryn are documented in the environment, mainly in waters, soil, and plants …
View article: A Ketogenic Diet in Combination with Gemcitabine Mitigates Pancreatic Cancer-Associated Cachexia in Male and Female KPC Mice
A Ketogenic Diet in Combination with Gemcitabine Mitigates Pancreatic Cancer-Associated Cachexia in Male and Female KPC Mice Open
Cancer-associated cachexia (CAC) is a critical contributor to pancreatic ductal adenocarcinoma (PDAC) mortality. Thus, there is an urgent need for new strategies to mitigate PDAC-associated cachexia; and the exploration of dietary interven…
View article: A Ketogenic Diet in Combination With Gemcitabine Mitigates Pancreatic Cancer Associated Cachexia in Male and Female KPC Mice
A Ketogenic Diet in Combination With Gemcitabine Mitigates Pancreatic Cancer Associated Cachexia in Male and Female KPC Mice Open
Cancer associated cachexia (CAC) is a critical contributor to pancreatic ductal adenocarcinoma (PDAC) mortality. Thus, there is an urgent need for new strategies to mitigate PDAC-associated cachexia; and the exploration of dietary interven…
View article: Western Blotting (immunoblotting): History, Theory, Uses, Protocol and Problems
Western Blotting (immunoblotting): History, Theory, Uses, Protocol and Problems Open
Western blotting (immunoblotting) is a powerful and commonly used technique that is capable of detecting or semiquantifying an individual protein from complex mixtures of proteins extracted from cells or tissues. The history surrounding th…
View article: Dominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats
Dominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats Open
The tumor suppressor p53 is thought to play a key role in the maintenance of cell size and homeostasis, but relatively little is known about its role in skeletal muscle. Based on its ability to suppress cell growth, we hypothesized that in…
View article: Detailed Western Blotting (Immunoblotting) Protocol v1
Detailed Western Blotting (Immunoblotting) Protocol v1 Open
Western Blotting, which is probably better referred to as immunoblotting, is one of the most commonly used biological methods worldwide. This technique is capable of detecting an individual protein from a complex mixture of proteins extrac…
View article: A Common Feature of Pesticides: Oxidative Stress—The Role of Oxidative Stress in Pesticide‐Induced Toxicity
A Common Feature of Pesticides: Oxidative Stress—The Role of Oxidative Stress in Pesticide‐Induced Toxicity Open
Pesticides are important chemicals or biological agents that deter or kill pests. The use of pesticides has continued to increase as it is still considered the most effective method to reduce pests and increase crop growth. However, pestic…