Rashid A. Madebe
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View article: Socio-demographic predictors of Insecticide-treated bed net ownership and utilization for protection against malaria by rural community members across five regions of Mainland Tanzania
Socio-demographic predictors of Insecticide-treated bed net ownership and utilization for protection against malaria by rural community members across five regions of Mainland Tanzania Open
Background Despite decades of control efforts by the National Malaria Control Programme, malaria burden in Tanzania remains high, with transmission intensity varying significantly across regions. Insecticide-treated bed nets (ITNs) are amo…
View article: Prevalence and risk factors associated with infections caused by Plasmodium parasites at micro-geographic level in three villages of Muheza district in Tanga region, north-eastern Tanzania
Prevalence and risk factors associated with infections caused by Plasmodium parasites at micro-geographic level in three villages of Muheza district in Tanga region, north-eastern Tanzania Open
The study villages had a high prevalence, and the risk of Plasmodium parasite infections was higher in school children (aged 5 to < 15 years). The prevalence and risk of infections varied significantly among the villages which are located …
View article: Temporal and spatial trends of the prevalence of infections caused by Plasmodium parasites among rural community members in three regions with varying transmission intensities in Mainland Tanzania
Temporal and spatial trends of the prevalence of infections caused by Plasmodium parasites among rural community members in three regions with varying transmission intensities in Mainland Tanzania Open
The prevalence of infections caused by Plasmodium parasites varied significantly over the 3 years, in the three regions, and among individuals with different demographic and clinical features. The highest prevalence was in 2023, and among …
View article: Malaria-malnutrition interaction: prevalence, risk factors, and the impact of intermittent preventive therapy for malaria on nutritional status of school-age children in Muheza, Tanga, Tanzania — A cross-sectional survey and a randomized controlled open-label trial
Malaria-malnutrition interaction: prevalence, risk factors, and the impact of intermittent preventive therapy for malaria on nutritional status of school-age children in Muheza, Tanga, Tanzania — A cross-sectional survey and a randomized controlled open-label trial Open
Although substantial efforts to control malaria are ongoing in the study setting, the dual burden of malaria and malnutrition remains significant. Anti-malaria use for preventive purpose may not be sufficient to improve nutritional status,…
View article: Varying Malaria Rapid Diagnostic Test Accuracy by Regional Transmission Level and Demographics in Tanzania
Varying Malaria Rapid Diagnostic Test Accuracy by Regional Transmission Level and Demographics in Tanzania Open
Malaria remains a significant global health burden, with approximately 263 million cases across 83 countries. It’s essential for malarial infection control to quickly and accurately detect cases. Given the widespread use of malaria rapid d…
View article: Genetic Metrics Decodes<i>Plasmodium falciparum</i>Diversity: Complexity of Infections, Parasite Connectivity, and Transmission Intensity in Mainland Tanzania’s Diverse Regions
Genetic Metrics Decodes<i>Plasmodium falciparum</i>Diversity: Complexity of Infections, Parasite Connectivity, and Transmission Intensity in Mainland Tanzania’s Diverse Regions Open
Background Recent initiatives have promoted the application of genomic data to determine the trends and patterns of malaria transmission and the impact of interventions. This study aimed to evaluate and identify the most effective genetic …
View article: Performance of rapid diagnostic tests, microscopy, and qPCR for detection of Plasmodium parasites among community members with or without symptoms of malaria in villages located in North-western Tanzania
Performance of rapid diagnostic tests, microscopy, and qPCR for detection of Plasmodium parasites among community members with or without symptoms of malaria in villages located in North-western Tanzania Open
View article: Prevalence of subpatent Plasmodium falciparum infections in regions with varying transmission intensities and implications for malaria elimination in Mainland Tanzania
Prevalence of subpatent Plasmodium falciparum infections in regions with varying transmission intensities and implications for malaria elimination in Mainland Tanzania Open
Background Subpatent Plasmodium falciparum infections, defined as infections with parasite density below the detection limit of routine malaria diagnostic tests, contribute to infectious reservoirs, sustain transmission, and cause the fail…
View article: Genetic diversity of Plasmodium falciparum reticulocyte binding protein homologue-5, which is a potential malaria vaccine candidate: baseline data from areas of varying malaria endemicity in Mainland Tanzania
Genetic diversity of Plasmodium falciparum reticulocyte binding protein homologue-5, which is a potential malaria vaccine candidate: baseline data from areas of varying malaria endemicity in Mainland Tanzania Open
Background The limited efficacy of the two recently approved malaria vaccines, RTS,S/AS01 and R21/Matrix- M™, highlights the need for alternative vaccine candidate genes. Plasmodium falciparum Reticulocyte Binding Protein Homologue 5 ( Pfr…
View article: Prevalence and drivers of malaria infection among asymptomatic and symptomatic community members in five regions with varying transmission intensity in mainland Tanzania
Prevalence and drivers of malaria infection among asymptomatic and symptomatic community members in five regions with varying transmission intensity in mainland Tanzania Open
Background Despite implementation of effective interventions in the past two decades, malaria is still a major public health problem in Tanzania. This study assessed the prevalence and drivers of malaria infections among symptomatic and as…
View article: Mapping of the country-wide prevalence of non-malarial febrile illnesses in areas with varying malaria transmission intensities in Mainland Tanzania
Mapping of the country-wide prevalence of non-malarial febrile illnesses in areas with varying malaria transmission intensities in Mainland Tanzania Open
Recent reports revealed a declining malaria burden, but non-malaria febrile illnesses (NMFIs) have either remained unchanged or increased. This study assessed the country-wide prevalence of NMFIs and their patterns across various malaria t…
View article: Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions among patients enrolled at 100 health facilities throughout Tanzania: February to July 2021
Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions among patients enrolled at 100 health facilities throughout Tanzania: February to July 2021 Open
View article: Prevalence of subpatent <i>Plasmodium falciparum</i> infections in regions with varying transmission intensities and implications for malaria elimination in Mainland Tanzania
Prevalence of subpatent <i>Plasmodium falciparum</i> infections in regions with varying transmission intensities and implications for malaria elimination in Mainland Tanzania Open
Background Subpatent Plasmodium falciparum infections, defined as infections with parasitaemia density below the detection limit of routine malaria diagnostic tests, contribute to infectious reservoirs, sustain transmission, and cause the …
View article: Prevalence of non-falciparum malaria infections among asymptomatic individuals in four regions of Mainland Tanzania
Prevalence of non-falciparum malaria infections among asymptomatic individuals in four regions of Mainland Tanzania Open
View article: Genetic polymorphism and evidence of signatures of selection in the Plasmodium falciparum circumsporozoite protein gene in Tanzanian regions with different malaria endemicity
Genetic polymorphism and evidence of signatures of selection in the Plasmodium falciparum circumsporozoite protein gene in Tanzanian regions with different malaria endemicity Open
View article: Prevalence of mutations associated with artemisinin partial resistance and sulfadoxine–pyrimethamine resistance in 13 regions in Tanzania in 2021: a cross-sectional survey
Prevalence of mutations associated with artemisinin partial resistance and sulfadoxine–pyrimethamine resistance in 13 regions in Tanzania in 2021: a cross-sectional survey Open
This study was funded by the Bill & Melinda Gates Foundation and the National Institutes of Health.
View article: Evidence of artemisinin partial resistance in northwestern Tanzania: clinical and molecular markers of resistance
Evidence of artemisinin partial resistance in northwestern Tanzania: clinical and molecular markers of resistance Open
View article: High prevalence and risk of malaria among asymptomatic individuals from villages with high prevalence of artemisinin partial resistance in Kyerwa district of Kagera region, north-western Tanzania
High prevalence and risk of malaria among asymptomatic individuals from villages with high prevalence of artemisinin partial resistance in Kyerwa district of Kagera region, north-western Tanzania Open
Background Although Tanzania adopted and has been implementing effective interventions to control and eventually eliminate malaria, the disease is still a leading public health problem, and the country experiences heterogeneous transmissio…
View article: Prevalence and drivers of malaria infections among asymptomatic individuals from selected communities in five regions of Mainland Tanzania with varying transmission intensities
Prevalence and drivers of malaria infections among asymptomatic individuals from selected communities in five regions of Mainland Tanzania with varying transmission intensities Open
Background Malaria is still a leading public health problem in Tanzania despite the implementation of effective interventions for the past two decades. Currently, the country experiences heterogeneous transmission and a higher malaria burd…
View article: Genetic polymorphism and evidence of signatures of selection in the Plasmodium falciparum circumsporozoite protein gene in Tanzanian regions with different malaria endemicity
Genetic polymorphism and evidence of signatures of selection in the Plasmodium falciparum circumsporozoite protein gene in Tanzanian regions with different malaria endemicity Open
View article: Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions among patients enrolled at 100 health facilities throughout Tanzania: February to July 2021
Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions among patients enrolled at 100 health facilities throughout Tanzania: February to July 2021 Open
View article: Prevalence of non-falciparum malaria infections among asymptomatic individuals in four regions of Mainland Tanzania
Prevalence of non-falciparum malaria infections among asymptomatic individuals in four regions of Mainland Tanzania Open
View article: Microsatellites reveal high polymorphism and high potential for use in anti-malarial efficacy studies in areas with different transmission intensities in mainland Tanzania
Microsatellites reveal high polymorphism and high potential for use in anti-malarial efficacy studies in areas with different transmission intensities in mainland Tanzania Open
Background Tanzania is currently implementing therapeutic efficacy studies (TES) in areas of varying malaria transmission intensities as per the World Health Organization (WHO) recommendations. In TES, distinguishing reinfection from recru…
View article: Trends of Plasmodium falciparum molecular markers associated with resistance to artemisinins and reduced susceptibility to lumefantrine in Mainland Tanzania from 2016 to 2021
Trends of Plasmodium falciparum molecular markers associated with resistance to artemisinins and reduced susceptibility to lumefantrine in Mainland Tanzania from 2016 to 2021 Open
Background Therapeutic efficacy studies (TESs) and detection of molecular markers of drug resistance are recommended by the World Health Organization (WHO) to monitor the efficacy of artemisinin-based combination therapy (ACT). This study …
View article: Prevalence and risk factors associated with malaria infections at a micro-geographic level in three villages of Muheza district, north-eastern Tanzania
Prevalence and risk factors associated with malaria infections at a micro-geographic level in three villages of Muheza district, north-eastern Tanzania Open
Background Despite a recent reduction in malaria morbidity and mortality, the disease remains a major cause of morbidity and mortality in Tanzania. However, the malaria burden is heterogeneous with a higher burden in some regions compared …
View article: Evidence of artemisinin partial resistance in North-western Tanzania: clinical and drug resistance markers study
Evidence of artemisinin partial resistance in North-western Tanzania: clinical and drug resistance markers study Open
Background Artemisinin-based combination therapies (ACTs) are the recommended antimalarial drugs for the treatment of uncomplicated malaria. The recent emergence of artemisinin partial resistance (ART-R) in Rwanda, Uganda and Eritrea is of…
View article: Genetic polymorphism and evidence of signatures of selection in the<i>Plasmodium falciparum</i>circumsporozoite protein gene in Tanzanian regions with different malaria endemicity
Genetic polymorphism and evidence of signatures of selection in the<i>Plasmodium falciparum</i>circumsporozoite protein gene in Tanzanian regions with different malaria endemicity Open
Background In 2021 and 2023, the World Health Organization approved RTS,S/AS01 and R21/Matrix M malaria vaccines, respectively, for routine immunization of children in African countries with moderate to high transmission. These vaccines ar…
View article: Trends of<i>Plasmodium falciparum</i>molecular markers associated with resistance to artemisinins and reduced susceptibility to lumefantrine in Mainland Tanzania from 2016 to 2021
Trends of<i>Plasmodium falciparum</i>molecular markers associated with resistance to artemisinins and reduced susceptibility to lumefantrine in Mainland Tanzania from 2016 to 2021 Open
Background Therapeutic efficacy studies (TESs) and detection of molecular markers of drug resistance are recommended by the World Health Organization (WHO) to monitor the efficacy of artemis inin combination therapy (ACT). This study asses…
View article: Evidence of Artemisinin Partial Resistance in North-Western Tanzania: Clinical and Drug Resistance Markers Study
Evidence of Artemisinin Partial Resistance in North-Western Tanzania: Clinical and Drug Resistance Markers Study Open
View article: Malaria species prevalence among asymptomatic individuals in four regions of Mainland Tanzania
Malaria species prevalence among asymptomatic individuals in four regions of Mainland Tanzania Open
Recent studies point to the need to incorporate non-falciparum species detection into malaria surveillance activities in sub-Saharan Africa, where 95% of malaria cases occur. Although Plasmodium falciparum infection is typically more sever…