Rashim Pal Singh
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View article: Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2
Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2 Open
Current vaccine efforts to combat SARS-CoV-2 are focused on the whole spike protein administered as mRNA, viral vector, or protein subunit. However, the SARS-CoV-2 receptor-binding domain (RBD) is the immunodominant portion of the spike pr…
View article: The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness Open
View article: Iron- and erythropoietin-resistant anemia in a spontaneous breast cancer mouse model
Iron- and erythropoietin-resistant anemia in a spontaneous breast cancer mouse model Open
Anemia of cancer (AoC) with its multifactorial etiology and complex pathology is a poor prognostic indicator for cancer patients. One of the main causes of AoC is cancer-associated inflammation that activates mechanisms, commonly observed …
View article: Transduction of Primary AML Cells with Lentiviral Vector for In Vitro Study or In Vivo Engraftment
Transduction of Primary AML Cells with Lentiviral Vector for In Vitro Study or In Vivo Engraftment Open
We describe a method to silence genes in primary acute myeloid leukemia cells by transducing them with shRNA in lentiviral vectors. The transduction of primary non-adherent cells is particularly challenging. The protocol will aid in perfor…
View article: Mitochondria regulate AML differentiation independent of oxidative phosphorylation and metabolism
Mitochondria regulate AML differentiation independent of oxidative phosphorylation and metabolism Open
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy originating from acquired mutations in stem and progenitor cells. While many patients achieve remission with upfront therapy, mo...
View article: Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal
Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal Open
View article: Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice
Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice Open
View article: Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche
Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche Open
Hematopoietic stem cells (HSCs) remain mostly quiescent under steady-state conditions but switch to a proliferative state following hematopoietic stress, e.g., bone marrow (BM) injury, transplantation, or systemic infection and inflammatio…
View article: Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells
Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells Open
The main oxygen sensor hypoxia inducible factor (HIF) prolyl hydroxylase 2 (PHD2) is a critical regulator of tissue homeostasis during erythropoiesis, hematopoietic stem cell maintenance, and wound healing. Recent studies point toward a ro…
View article: 10th international Luebeck conference on the pathophysiology and pharmacology of erythropoietin and other hemopoietic growth factors
10th international Luebeck conference on the pathophysiology and pharmacology of erythropoietin and other hemopoietic growth factors Open
It has been suggested that the erythropoietin receptor (EpoR) can not only be found on erythroid precursor cells but also on the surface of certain tumour cells where it might enhance tumour proliferation if patients are treated with Epo t…