Rashin Mohseni
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View article: Long-Term Outcomes of Non-Total Body Irradiation Hematopoietic Stem Cell Transplantation in Pediatric Secondary Malignancies: Experience from a Single Center
Long-Term Outcomes of Non-Total Body Irradiation Hematopoietic Stem Cell Transplantation in Pediatric Secondary Malignancies: Experience from a Single Center Open
Secondary malignancies (SMs) are one of the concerning challenges in oncology, referring to the development of a new neoplasm unrelated to the primary tumor. In this study, we evaluated the outcomes of HSCT with a non-total body irradiatio…
View article: Viral-based gene therapy clinical trials for immune deficiencies and blood disorders from 2013 until 2023 - an overview
Viral-based gene therapy clinical trials for immune deficiencies and blood disorders from 2013 until 2023 - an overview Open
Gene therapy (GT) as a groundbreaking approach holds promise for treating many diseases including immune deficiencies and blood disorders. GT can benefit patients suffering from these diseases, especially those without matched donors or wh…
View article: Phase I study of safety and efficacy of allogeneic natural killer cell therapy in relapsed/refractory neuroblastomas post autologous hematopoietic stem cell transplantation
Phase I study of safety and efficacy of allogeneic natural killer cell therapy in relapsed/refractory neuroblastomas post autologous hematopoietic stem cell transplantation Open
Despite low incidence, neuroblastoma, an immunologically cold tumor, is the most common extracranial solid neoplasm in pediatrics. In relapsed/refractory cases, the benefits of autologous hematopoietic stem cell transplantation (auto-HSCT)…
View article: Evaluation of safety and efficacy of allogeneic adipose tissue-derived mesenchymal stem cells in pediatric bronchiolitis obliterans syndrome (BoS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT)
Evaluation of safety and efficacy of allogeneic adipose tissue-derived mesenchymal stem cells in pediatric bronchiolitis obliterans syndrome (BoS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) Open
View article: Posterior Reversible Encephalopathy Syndrome in Pediatric Hematopoietic Stem Cell Transplantation with Beta Major Thalassemia: The Association between the PRES Occurrence and Class of Beta Major Thalassemia
Posterior Reversible Encephalopathy Syndrome in Pediatric Hematopoietic Stem Cell Transplantation with Beta Major Thalassemia: The Association between the PRES Occurrence and Class of Beta Major Thalassemia Open
Allogeneic hematopoietic stem cell transplantation (HSCT) is the only definitive curative option for β-major thalassemia patients (β-MT). Posterior reversible encephalopathy syndrome (PRES) is a pervasive neurological complication which ty…
View article: Fanconi anemia phenotypic and transplant outcomes' associations in Iranian patients
Fanconi anemia phenotypic and transplant outcomes' associations in Iranian patients Open
Objectives Fanconi anemia (FA) is a rare, heterogeneous, inherited disorder. Allogeneic hematopoietic stem cell transplantation (HSCT) represents the only therapeutic option to restore normal hematopoiesis. This study reports the outcomes …
View article: The Safety and Feasibility of Intra Surgical Cavity or intra Cerebrospinal Fluid (CSF) Injection of Haploidentical Activated NK Cells in Patients with Recurrent Glioblastoma Multiforme and Brain Tumors
The Safety and Feasibility of Intra Surgical Cavity or intra Cerebrospinal Fluid (CSF) Injection of Haploidentical Activated NK Cells in Patients with Recurrent Glioblastoma Multiforme and Brain Tumors Open
Despite multi-modal therapies for patients with malignant brain tumors, their median survival is < 2 year. Recently, NK cells provided to cancer immune surveillance through their direct natural cytotoxicity, by modulating dendritic cells t…
View article: Long-term follow-up of patients with LPS-responsive beige-like anchor protein deficiency after reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation: report of two cases
Long-term follow-up of patients with LPS-responsive beige-like anchor protein deficiency after reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation: report of two cases Open
View article: Successful allogeneic stem cell transplantation with a reduced-intensity conditioning in a case of leukocyte adhesion deficiency type III
Successful allogeneic stem cell transplantation with a reduced-intensity conditioning in a case of leukocyte adhesion deficiency type III Open
View article: Escalated dose donor lymphocyte infusion treatment in patients with primary immune deficiencies after HSCT with reduced-intensity conditioning regimen
Escalated dose donor lymphocyte infusion treatment in patients with primary immune deficiencies after HSCT with reduced-intensity conditioning regimen Open
Objective/Background: Mixed chimerism is a major concern after allogenic hematopoietic stem cell transplantation (HSCT) using a reduced-intensity conditioning (RIC) regimen in primary immunodeficiencies (PIDs). A donor lymphocyte infusion …
View article: Activation of Natural killer cells with interleukin 21 in the treatment of preclinical Neuroblastoma model
Activation of Natural killer cells with interleukin 21 in the treatment of preclinical Neuroblastoma model Open
Background: Neuroblastoma (NB) is one of the most prevalent children's neoplasm and some of which still do not respond to common treatments and is an ideal candidate for NK cell immune therapy. In this research, we have performed cytokine …
View article: An optimized protocol for Isolation, Expansion and Activation of Natural Killer cells from human Adipose Tissue
An optimized protocol for Isolation, Expansion and Activation of Natural Killer cells from human Adipose Tissue Open
Adipose tissue has a heterogeneous cell population consists of adipocytes, mesenchymal stromal cells (MSCs), endothelial cells, pericytes, fibroblasts and etc. Also, it harbors immune cell types including macrophages, neutrophils, mast cel…
View article: Clinical outcome of the Intrathecal administration of the allogeneic side population Adipose Derived Mesenchymal Stem Cells in Werdnig Hoffman patients: An open-label Phase I clinical trial
Clinical outcome of the Intrathecal administration of the allogeneic side population Adipose Derived Mesenchymal Stem Cells in Werdnig Hoffman patients: An open-label Phase I clinical trial Open
Background Werdnig Hoffman (WH), a hereditary neurodegenerative disorder of lower motoneurons associated with progressive muscle weakness is the most common genetic cause of infant mortality. There is no effective treatment for WH exists. …
View article: Evaluation of the Phenotypic and Genotypic Effects of Satureja Khuzestanica Essence and Copper Nanocomplex on the Expression of Alkaline Protease Gene in Pseudomonas Aeruginosa by RT-PCR Method
Evaluation of the Phenotypic and Genotypic Effects of Satureja Khuzestanica Essence and Copper Nanocomplex on the Expression of Alkaline Protease Gene in Pseudomonas Aeruginosa by RT-PCR Method Open
Background & aim: Pseudomonas aeruginosa is a gram-negative bacillus and an opportunistic pathogen that causes high mortality in immunocompromised patients. The main antimicrobial activity of Satureja khuzestanica essence is due to carvacr…
View article: Natural Killer Cells Treated with CD11b Expressing Subpopulation of Exosomes Show Highly Activated Phenotype Against Neuroblastoma: A Future Prospect for the Treatment of High-Risk Neuroblastoma
Natural Killer Cells Treated with CD11b Expressing Subpopulation of Exosomes Show Highly Activated Phenotype Against Neuroblastoma: A Future Prospect for the Treatment of High-Risk Neuroblastoma Open
Natural killer (NK) cell therapy has emerged as the treatment of relapses occurring after hematopoietic stem cell transplantation performed for the high-risk neuroblastoma (NB). NK cell-generated exosomes are known to be involved in interc…
View article: Natural Killer Cells from the Subcutaneous Adipose Tissue Underexpress the NKp30 and NKp44 in Obese Persons and Are Less Active against Major Histocompatibility Complex Class I Non-Expressing Neoplastic Cells
Natural Killer Cells from the Subcutaneous Adipose Tissue Underexpress the NKp30 and NKp44 in Obese Persons and Are Less Active against Major Histocompatibility Complex Class I Non-Expressing Neoplastic Cells Open
There are many types of leukocytes reside in subcutaneous adipose tissue (SAT), and among them, natural killer cells (NKs) comprise a major part. We show that the NKs that reside in the SAT (adipose tissue-derived NK cells; ADNKs) of the a…
View article: Limitations in Clinical Translation of Nanoparticle-Based Gene Therapy
Limitations in Clinical Translation of Nanoparticle-Based Gene Therapy Open
View article: NK Cell–derived Exosomes From NK Cells Previously Exposed to Neuroblastoma Cells Augment the Antitumor Activity of Cytokine-activated NK Cells
NK Cell–derived Exosomes From NK Cells Previously Exposed to Neuroblastoma Cells Augment the Antitumor Activity of Cytokine-activated NK Cells Open
Immune cell–derived exosomes can increase immunity against tumors. In contrast, tumor-derived exosomes can reduce the immunity and can change the tumor microenvironment to further develop and provide metastasis. These effects take place by…
View article: A rapid sonication based method for preparation of stromal vascular fraction and mesenchymal stem cells from fat tissue
A rapid sonication based method for preparation of stromal vascular fraction and mesenchymal stem cells from fat tissue Open
The current protocol based on the sonication-mediated cavitation is a rapid, safe and cost-effective method, which is proposed for isolation of SVF and of course ADSCs cultures in a large scale for the clinical trials or therapeutic purpos…
View article: Antimicrobial effect of hydroalcoholic extract of saturega multica and zinc oxide namoparticle on coagulase gene expression on clinical and standard samples of MRSA (Methicilin resistant staph aureus)
Antimicrobial effect of hydroalcoholic extract of saturega multica and zinc oxide namoparticle on coagulase gene expression on clinical and standard samples of MRSA (Methicilin resistant staph aureus) Open
Background & aim: Methicillin-resistant Staphylococcus aureus (MRSA) as nosocomial pathogens have been causing severe and deadly diseases around the world. Coagulase is an important virulence factor for this bacterium and exisist in all s…