Rashmi G. Shah
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View article: Role of poly(ADP-ribose) polymerase-1 in regulating human islet cell differentiation
Role of poly(ADP-ribose) polymerase-1 in regulating human islet cell differentiation Open
Poly(ADP-ribose) polymerase-1 (PARP1), a fundamental DNA repair enzyme, is known to regulate β cell death, replication, and insulin secretion. PARP1 knockout (KO) mice are resistant to diabetes, while PARP1 overactivation contributes to β …
View article: XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair
XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair Open
View article: Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates
Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates Open
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Here, we compare the contributions of the proteasome and DUB…
View article: Catalytic-independent function of PARP-1 is essential in regulating human islet-cell differentiation from stem cells
Catalytic-independent function of PARP-1 is essential in regulating human islet-cell differentiation from stem cells Open
Poly (ADP) Ribose Polymerase-1 (PARP-1), a fundamental DNA repair enzyme is known to regulate β cell death, replication, and insulin secretion. PARP-1 knockout (KO) mice are resistant to diabetes while PARP-1 overactivation contributes to …
View article: Chemotherapy-Induced Upregulation of Somatostatin Receptor-2 Increases the Uptake and Efficacy of 177Lu-DOTA-Octreotate in Neuroendocrine Tumor Cells
Chemotherapy-Induced Upregulation of Somatostatin Receptor-2 Increases the Uptake and Efficacy of 177Lu-DOTA-Octreotate in Neuroendocrine Tumor Cells Open
The peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTA-octreotate (LuTate) is recommended for different types of neuroendocrine tumors (NETs) which overexpress somatostatin receptors (SSTR). A combination with chemotherapy improv…
View article: Poly(ADP-ribosyl)ation temporally confines SUMO-dependent ataxin-3 recruitment to control DNA double-strand break repair
Poly(ADP-ribosyl)ation temporally confines SUMO-dependent ataxin-3 recruitment to control DNA double-strand break repair Open
DNA damage-induced SUMOylation serves as a signal for two antagonizing proteins that both stimulate repair of DNA double-strand breaks (DSBs). Here, we demonstrate that the SUMO-dependent recruitment of the deubiquitylating enzyme ataxin-3…
View article: Methods to Study Intracellular Movement and Localization of the Nucleotide Excision Repair Proteins at the DNA Lesions in Mammalian Cells
Methods to Study Intracellular Movement and Localization of the Nucleotide Excision Repair Proteins at the DNA Lesions in Mammalian Cells Open
Nucleotide excision repair (NER) is the most versatile DNA repair pathway that removes a wide variety of DNA lesions caused by different types of physical and chemical agents, such as ultraviolet radiation (UV), environmental carcinogen be…
View article: Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome
Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome Open
The autosomal recessive immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a genetically heterogeneous disorder. Despite the identification of the underlying gene defects, it is unclear how mutations in any o…
View article: Potentiation of 177Lu-octreotate peptide receptor radionuclide therapy of human neuroendocrine tumor cells by PARP inhibitor
Potentiation of 177Lu-octreotate peptide receptor radionuclide therapy of human neuroendocrine tumor cells by PARP inhibitor Open
For patients with inoperable neuroendocrine tumors (NETs) expressing somatostatin receptors, peptide receptor radionuclide therapy (PRRT) with 177Lu-[DOTA0-Tyr3]-octreotate (177Lu-octreotate) is one of the most promis…
View article: Poly(ADP-ribose) polymerase 1 escorts XPC to UV-induced DNA lesions during nucleotide excision repair
Poly(ADP-ribose) polymerase 1 escorts XPC to UV-induced DNA lesions during nucleotide excision repair Open
Significance Repair of the majority of UV-induced DNA damage in mammalian cells by the nucleotide excision repair pathway starts with rapid recruitment of Xeroderma pigmentosum C (XPC) protein to the lesion. However, rapidity of XPC recrui…
View article: PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining
PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining Open
The response to DNA double-strand breaks (DSBs) requires alterations in chromatin structure to promote the assembly of repair complexes on broken chromosomes. Non-homologous end-joining (NHEJ) is the dominant DSB repair pathway in human ce…
View article: Characterization of the interactions of PARP-1 with UV-damaged DNA in vivo and in vitro
Characterization of the interactions of PARP-1 with UV-damaged DNA in vivo and in vitro Open
The existing methodologies for studying robust responses of poly (ADP-ribose) polymerase-1 (PARP-1) to DNA damage with strand breaks are often not suitable for examining its subtle responses to altered DNA without strand breaks, such as UV…