Rasika M. Samarasinghe
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Tuning Cellular Perception in Pluripotent Stem Cells through Topography, Stiffness, and Patterning Open
Pluripotent stem cells (PSCs), comprised of embryonic stem cells and induced PSCs, hold tremendous therapeutic potential. This has been driven by transformative advances in cell engineering and manufacturing, from fundamental research to c…
Neuroanatomical distribution of fluorophores within adult RXFP3 Cre-tdTomato/YFP mouse brain Open
Relaxin-family peptide 3 receptor (RXFP3) is activated by relaxin-3 in the brain to influence arousal and related functions, such as feeding and stress responses. Two transgenic mouse lines have recently been developed that co-express diff…
Novel insights on genetics and epigenetics as clinical targets for paediatric astrocytoma Open
Paediatric and adult astrocytomas are notably different, where clinical treatments used for adults are not as effective on children with the same form of cancer and these treatments lead to adverse long‐term health concerns. Integrative om…
View article: Lithium use and bone health in women with bipolar disorder: A cross‐sectional study
Lithium use and bone health in women with bipolar disorder: A cross‐sectional study Open
Introduction Several psychiatric disorders and medications used to treat them appear to be independently associated with skeletal deficits. As there is increasing evidence that lithium possesses skeletal protective properties, we aimed to …
View article: Unravelling the Glioblastoma Tumour Microenvironment: Can Aptamer Targeted Delivery Become Successful in Treating Brain Cancers?
Unravelling the Glioblastoma Tumour Microenvironment: Can Aptamer Targeted Delivery Become Successful in Treating Brain Cancers? Open
The key challenges to treating glioblastoma multiforme (GBM) are the heterogeneous and complex nature of the GBM tumour microenvironment (TME) and difficulty of drug delivery across the blood–brain barrier (BBB). The TME is composed of var…
Antipsychotic medication use and fracture: a case–control study Open
It has been reported that antipsychotic use is associated with lower bone mineral density and bone quality. We aimed to determine whether antipsychotic use is associated with fracture risk in a population-based sample of adults living in t…
View article: Unravelling the Glioblastoma Tumour Microenvironment: Can Aptamer Targeted Delivery Emerge Successful in Treating Brain Cancers?
Unravelling the Glioblastoma Tumour Microenvironment: Can Aptamer Targeted Delivery Emerge Successful in Treating Brain Cancers? Open
The key challenges to treating glioblastoma multiforme (GBM) are the heterogenous and complex nature of the GBM tumour microenvironment (TME) and difficulty of drug delivery across the blood-brain barrier (BBB). The TME is composed of vari…
Biofabrication of functional bone tissue: defining tissue-engineered scaffolds from nature Open
Damage to bone leads to pain and loss of movement in the musculoskeletal system. Although bone can regenerate, sometimes it is damaged beyond its innate capacity. Research interest is increasingly turning to tissue engineering (TE) process…
Antipsychotic medication use in association with quantitative heel ultrasound (QUS) Open
Antipsychotic use was associated with lower QUS parameters. The risk of bone deterioration should be considered when antipsychotics are prescribed.
Antipsychotic-induced bone loss: the role of dopamine, serotonin and adrenergic receptor signalling Open
Antipsychotics are commonly used in treating psychiatric disorders. These medications primarily target dopamine the serotonin receptors, they have some affinity to adrenergic, histamine, glutamate and muscarinic receptors. There is clinica…
Use of antipsychotic medication and its relationship with bone mineral density: A population-based study of men and women Open
Background Schizophrenia has been shown to be associated with reduced bone mineral density (BMD) and higher fracture risk. However, less is known whether antipsychotic treatment is associated with reduced BMD. Thus, we aimed to examine ass…
Zebrafish Models of Paediatric Brain Tumours Open
Paediatric brain cancer is the second most common childhood cancer and is the leading cause of cancer-related deaths in children. Despite significant advancements in the treatment modalities and improvements in the 5-year survival rate, it…
Self-Assembled Peptide Habitats to Model Tumor Metastasis Open
Metastatic tumours are complex ecosystems; a community of multiple cell types, including cancerous cells, fibroblasts, and immune cells that exist within a supportive and specific microenvironment. The interplay of these cells, together wi…
View article: Anticonvulsant use and fracture: a case-control study.
Anticonvulsant use and fracture: a case-control study. Open
Anticonvulsant use was associated with increased fracture risk, independent of demographic, lifestyle, medical and medication related factors. While further studies exploring potential underlying mechanisms are warranted, regular monitorin…
Evaluation of Polypropylene Spun-bond Nets for Viral Disease Management in Bitter Gourd (<em>Mormodica charantia</em> L.) Open
Bitter gourd (Momordica charantia L.) is one of the highly susceptible cucurbits to viral diseases which transmits mainly via insect vectors. The success of existing pest control techniques is limited. Thus, investigating new pest control …
View article: Anticonvulsant use and bone health in a population-based study of men and women: cross-sectional data from the Geelong Osteoporosis Study.
Anticonvulsant use and bone health in a population-based study of men and women: cross-sectional data from the Geelong Osteoporosis Study. Open
Background: Anticonvulsant use has been linked to bone deficits in specific patient populations. We studied the association between anticonvulsant use and bone health in a population-based sample of men and women.Methods: Data from 926 men…
Augmented reality in medical education: students’ experiences and learning outcomes Open
Augmented reality (AR) is a relatively new technology that allows for digitally generated three-dimensional representations to be integrated with real environmental stimuli. AR can make use of smart phones, tablets, or other devices to ach…
View article: Anticonvulsant use and bone health in a population-based study of men and women: cross-sectional data from the Geelong Osteoporosis Study.
Anticonvulsant use and bone health in a population-based study of men and women: cross-sectional data from the Geelong Osteoporosis Study. Open
Background: Anticonvulsant use has been linked to bone deficits in specific patient populations. We studied the association between anticonvulsant use and bone health in a population-based sample of men and women. Methods: Data from 926 me…
Anticonvulsant Use and Bone Health in a Population-based Study of Men and Women: Cross-sectional Data from the Geelong Osteoporosis Study. Open
Background: Anticonvulsant use has been linked to bone deficits in specific patient populations. We studied the association between anticonvulsant use and bone health in a population-based sample of men and women. Methods: Data from 1996 p…
View article: Non-Invasive Delivery of Therapeutics into the Brain: The Potential of Aptamers for Targeted Delivery
Non-Invasive Delivery of Therapeutics into the Brain: The Potential of Aptamers for Targeted Delivery Open
The blood-brain barrier (BBB) is a highly specialised network of blood vessels that effectively separates the brain environment from the circulatory system. While there are benefits, in terms of keeping pathogens from entering the brain, t…
View article: Antibodies, Nanobodies, or Aptamers—Which Is Best for Deciphering the Proteomes of Non-Model Species?
Antibodies, Nanobodies, or Aptamers—Which Is Best for Deciphering the Proteomes of Non-Model Species? Open
This planet is home to countless species, some more well-known than the others. While we have developed many techniques to be able to interrogate some of the “omics”, proteomics is becoming recognized as a very important part of the puzzle…
Epigenetic altering drugs as immunotherapies. Open
Despite of our increasing understanding of the molecular, genetic and phenotypic progression of cancers, treatments that can effectively combat most malignant cancers remain suboptimal [1]. A major challenge with current therapies is that …
<em>Cissus quadrangularis</em> inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling [Corrigendum] Open
[This corrects the article on p. 2927 in vol. 9.].