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View article: A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites
A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites Open
Radical cure of Plasmodium vivax malaria must include elimination of quiescent ‘hypnozoite’ forms in the liver; however, the only FDA-approved treatments are contraindicated in many vulnerable populations. To identify new drugs and drug ta…
View article: A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites
A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites Open
Radical cure of Plasmodium vivax malaria must include elimination of quiescent ‘hypnozoite’ forms in the liver; however, the only FDA-approved treatments are contraindicated in many vulnerable populations. To identify new drugs and drug ta…
View article: A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites
A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites Open
Radical cure of Plasmodium vivax malaria must include elimination of quiescent ‘hypnozoite’ forms in the liver; however, the only FDA-approved treatments are contraindicated in many vulnerable populations. To identify new drugs and drug ta…
View article: A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in <i>Plasmodium vivax</i> Hypnozoites
A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in <i>Plasmodium vivax</i> Hypnozoites Open
Radical cure of Plasmodium vivax malaria must include elimination of quiescent ‘hypnozoite’ forms in the liver; however, the only FDA-approved treatments are contraindicated in many vulnerable populations. To identify new drugs and drug ta…
View article: Vector Competence and the Susceptibility of <i>Anopheles pullus</i> and <i>Anopheles belenrae</i> to <i>Plasmodium vivax</i>-Infected Blood From Thai Patients
Vector Competence and the Susceptibility of <i>Anopheles pullus</i> and <i>Anopheles belenrae</i> to <i>Plasmodium vivax</i>-Infected Blood From Thai Patients Open
There are eight Anopheles spp. present in the Republic of Korea (ROK), including five members of the Anopheles Hyrcanus Group that cannot be identified using current morphological methods. The vector competence of only Anopheles sinensis s…
View article: Microscopic Plasmodium falciparum Gametocytemia and Infectivity to Mosquitoes in Cambodia
Microscopic Plasmodium falciparum Gametocytemia and Infectivity to Mosquitoes in Cambodia Open
Although gametocytes are essential for malaria transmission, in Africa many falciparum-infected persons without smear-detectable gametocytes still infect mosquitoes. To see whether the same is true in Southeast Asia, we determined the infe…
View article: A novel CRISPR-based malaria diagnostic capable of<i>Plasmodium</i>detection, speciation, and drug-resistance genotyping
A novel CRISPR-based malaria diagnostic capable of<i>Plasmodium</i>detection, speciation, and drug-resistance genotyping Open
CRISPR-based diagnostics are a new class of highly sensitive and specific assays with multiple applications in infectious disease diagnosis. SHERLOCK, or Specific High-Sensitivity Enzymatic Reporter UnLOCKing, is one such CRISPR-based diag…
View article: Efficient Transmission of Mixed Plasmodium falciparum/vivax Infections From Humans to Mosquitoes
Efficient Transmission of Mixed Plasmodium falciparum/vivax Infections From Humans to Mosquitoes Open
Background In Southeast Asia, people are often coinfected with different species of malaria (Plasmodium falciparum [Pf] and Plasmodium vivax [Pv]) as well as with multiple clones of the same species. Whether particular species or clones wi…
View article: Hepatic spheroids used as an in vitro model to study malaria relapse
Hepatic spheroids used as an in vitro model to study malaria relapse Open
Hypnozoites are the liver stage non-dividing form of the malaria parasite that are responsible for relapse and acts as a natural reservoir for human malaria Plasmodium vivax and P. ovale as well as a phylogenetically related simian malaria…
View article: Population Genetics of Plasmodium vivax in Four High Malaria Endemic Areas in Thailand
Population Genetics of Plasmodium vivax in Four High Malaria Endemic Areas in Thailand Open
Recent trends of malaria in Thailand illustrate an increasing proportion of Plasmodium vivax, indicating the importance of P. vivax as a major causative agent of malaria. P. vivax malaria is usually considered a benign disease so the knowl…
View article: Strict tropism for CD71+/CD234+ human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi
Strict tropism for CD71+/CD234+ human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi Open
Key Points Zoonotic P cynomolgi switches red cell tropism for reticulocytes expressing Trf1 (CD71+) and DARC (CD234+). In the human host, P cynomolgi displays an almost identical rheopathobiology to P vivax.
View article: Single dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission in Cambodia: An open-label randomized trial
Single dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission in Cambodia: An open-label randomized trial Open
In a setting of established ACT resistance, a single dose of 45mg primaquine added to DHP rapidly and significantly reduced gametocytemia, while DHP-alone failed to reduce gametocytemia and prevent malaria transmission to mosquitoes. Conti…
View article: Chemoprophylaxis with sporozoite immunization in P. knowlesi rhesus monkeys confers protection and elicits sporozoite-specific memory T cells in the liver
Chemoprophylaxis with sporozoite immunization in P. knowlesi rhesus monkeys confers protection and elicits sporozoite-specific memory T cells in the liver Open
Whole malaria sporozoite vaccine regimens are promising new strategies, and some candidates have demonstrated high rates of durable clinical protection associated with memory T cell responses. Little is known about the anatomical distribut…
View article: Vector Competence of<i>Anopheles kleini</i>and<i>Anopheles sinensis</i>(Diptera: Culicidae) From the Republic of Korea to Vivax Malaria-Infected Blood From Patients From Thailand
Vector Competence of<i>Anopheles kleini</i>and<i>Anopheles sinensis</i>(Diptera: Culicidae) From the Republic of Korea to Vivax Malaria-Infected Blood From Patients From Thailand Open
In total, 1,300 each of Anopheles kleini Rueda and Anopheles sinensis Wiedemann sensu stricto (s.s.) females (colonized from the Republic of Korea) and Anopheles dirus Peyton & Harrison (Thai strain) were allowed to feed on blood from Thai…
View article: Microscopic<i>Plasmodium falciparum</i>Gametocytemia and Infectivity to Mosquitoes in Cambodia
Microscopic<i>Plasmodium falciparum</i>Gametocytemia and Infectivity to Mosquitoes in Cambodia Open
Although gametocytes are essential for malaria transmission, in Africa many falciparum-infected persons without smear-detectable gametocytes still infect mosquitoes. To see whether the same is true in Southeast Asia, we determined the infe…